Editorial: Mechanisms of Developmental and Reproductive Toxicology of Ultrafine and Nano-Sized Particles
Masakazu Umezawa
Atsuto Onoda
Yasser Said El-Sayed- 1Department of Materials Science and Technology, Faculty of Advanced Engineering, Tokyo University of Science, Tokyo, Japan
- 2Division of Toxicology and Health Science, Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University, Yamaguchi, Japan
- 3Department of Veterinary Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Damanhour University, Damanhour, Egypt
Editorial on the Research Topic
Mechanisms of Developmental and Reproductive Toxicology of Ultrafine and Nano-Sized Particles
Fine particulate matter, i.e., particles with a diameter smaller than 2.5 μm (PM2.5), is still a global issue in public health (Li et al., 2015; Lelieveld et al., 2015). Particle toxicity has been studied for coal mining dust since the 19th Century, combustion-derived particles since the Industrial Revolution, and diesel exhaust particles constituting the main component of PM2.5 since the 20th Century (Riediker et al., 2019). One health effect that has been focused in emerging evidence is that the developing fetus is susceptible to atmospheric PM2.5 containing nanoparticles. In humans, exposure to ambient particulate air pollution during pregnancy has been associated with fetal growth perturbations, childhood asthma (Wright et al., 2021), and neurobehavior (Raz et al., 2015). Previously, the developmental effects of particulate air pollution, including diesel exhaust particles, were primarily attributed to the endocrine-disrupting effects of organic chemicals, such as polycyclic aromatic hydrocarbons, adsorbed to the particles. Within the past decade, the proposed mechanisms instead involve the particles’ properties.
In addition to ambient PM2.5 containing a large proportion of ultrafine (nanosized) particles, the emerging industry has begun to apply engineering of well-designed nanoparticles in a wide range of products, including consumer and biomedical use. The unique intrapulmonary distribution after inhalation and the translocation of nanoparticles across the placenta have been described. Developmental toxicity, following exposure of pregnant animals to nanoparticles (diesel soot, carbon black, etc.,), has been observed relative to the offspring’s male reproductive system (Yoshida et al., 2010; Kyjovska et al., 2013), the immune system (El-Sayed et al., 2015) that can link to asthma susceptibility (Hazlehurst et al., 2021), the cardiovascular system (Ni et al., 2021), and the central nervous system of the brain (Umezawa et al., 2018). Oxidative stress likely plays an important role in nanoparticle toxicity, as pre-treatment with antioxidants partially suppresses the developmental toxicity of nanoparticles (Onoda et al., 2017). Our understanding of the developmental nanoparticle toxicity mechanisms should be broadened and reviewed in detail for better risk assessment and management for protecting the health of expecting mothers and their children.
This research topic collected two review articles and two original research articles. The collected articles cover the potential mechanism of the toxicity of nanoparticles on the development of the male reproductive system, immune system, and central nervous system. The roles of endogenous antioxidative activity and epigenetics in developmental particle toxicity are also reported.
Yokota et al. reviewed the effect of maternal exposure to nanoparticles on the reproductive health of male offspring. As well, they examined the negative effects of nanoparticles on male germ cells, which require multiple epigenetic reprogramming events during their lifespan to acquire reproductive capacity by altering epigenetic regulation, which may, in turn, affect embryo development. Especially, this review provides a better understanding of the possibility of nanoparticle-induced developmental male infertility based on the spermatogenesis process and changes in small non-coding RNA expression as an early biomarker of developmental toxicity in testes by prenatal nanoparticle exposure.
Li et al. reviewed the potential contribution of a major endogenous antioxidative pathway, NRF2 pathway, in preventing developmental and reproductive toxicity of fine particles. While the potential chemoprevention of the developmental toxicity of nanoparticles has been reported via the antioxidative strategy (Onoda et al., 2015), the research on the effect of endogenous antioxidative factors on developmental nanoparticle toxicity is limited. This review shows the importance of understanding the endogenous pathway for a better preventive strategy for risk management of nanoparticles based on their potential of developmental toxicity.
Onoda et al. evaluated the impact of maternal exposure to carbon-black nanoparticles via nasal instillation in mice during 3 developmental periods (embryogenesis, organogenesis, fetal) on the spleen and thymus phenotype after birth. The main findings from this study are that changes to the immune profile of offspring are impacted most during a limited window of gestational exposure to nanoparticles during the organogenesis period (gestational days 8 and 9 in mice) and that these changes manifest in the increase of non-T/non-B immune cells in the spleen. The results suggest that the organogenesis period was the most susceptible period to CB-NP exposure concerning lymphoid tissue development. The information provided by this article will be related to future strategies for preventing developmental immunotoxicity and allergic diseases caused by particulate air pollution.
Tachibana et al. reported that TiO2 nanoparticle exposure during gestation results in altered DNA methylation and gene expression in the brain of mice at postnatal day 1. Bioinformatics functional analysis of differentially expressed genes highlighted systems including stem cells and morphogenesis being altered due to the exposure. The method presented in this article for extracting biologically functional information from comprehensive numerical data of epigenome and transcriptome is expected to contribute to further investigations of bio/toxicological effects of environmental factors not limited to nanoparticles.
The mechanism of developmental nanoparticle toxicity is likely to be still complex and important. We hope this article collection will make people understand comprehensively and sometimes simply the toxicological mechanisms for a more effective approach to prevent negative impacts of unintentional exposure of nanoparticles on future children’s healthy life.
Author Contributions
MU conceived this Research Topic. MU, AO, and YE are contributed to the formulation of the objectives and substantially managed of this Topic.
Conflict of Interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s Note
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References
El-Sayed, Y. S., Shimizu, R., Onoda, A., Takeda, K., and Umezawa, M. (2015). Carbon Black Nanoparticle Exposure during Middle and Late Fetal Development Induces Immune Activation in Male Offspring Mice. Toxicology. 327, 53–61. doi:10.1016/j.tox.2014.11.005
Hazlehurst, M. F., Carroll, K. N., Loftus, C. T., Szpiro, A. A., Moore, P. E., Kaufman, J. D., et al. (2021). Maternal Exposure to PM2.5 during Pregnancy and Asthma Risk in Early Childhood. Environ. Epidemiol. 5, e130. doi:10.1097/ee9.0000000000000130
Kyjovska, Z. O., Boisen, A. M. Z., Jackson, P., Wallin, H., Vogel, U., and Hougaard, K. S. (2013). Daily Sperm Production: Application in Studies of Prenatal Exposure to Nanoparticles in Mice. Reprod. Toxicol. 36, 88–97. doi:10.1016/j.reprotox.2012.12.005
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Li, Y. J., Umezawa, M., Takizawa, H., Takeda, K., and Kawada, T. (2015). PM2.5 -Role of Oxidative Stress in Health Effects and Prevention Strategy. NY, USA: Nova Science Publishers, Inc.
Ni, Y., Szpiro, A. A., Young, M. T., Loftus, C. T., Bush, N. R., LeWinn, K. Z., et al. (2021). Associations of Pre- and Postnatal Air Pollution Exposures with Child Blood Pressure and Modification by Maternal Nutrition: A Prospective Study in the CANDLE Cohort. Environ. Health Perspect. 129, 47004. doi:10.1289/EHP7486
Onoda, A., Takeda, K., and Umezawa, M. (2017). Pretreatment with N-Acetyl Cysteine Suppresses Chronic Reactive Astrogliosis Following Maternal Nanoparticle Exposure during Gestational Period. Nanotoxicology. 11 (8), 1012–1025. doi:10.1080/17435390.2017.1388864
Onoda, A., Umezawa, M., and Takeda, K. (2015). “The Potential Protective Effect of Antioxidants on Nanoparticle Toxicity,”. Chapter 15 in PM2.5 -Role of Oxidative Stress in Health Effects and Prevention Strategy-, 197–210. Editor Y. J. Li (NY, USA: Published by Nova Science Publishers, Inc.).
Raz, R., Roberts, A. L., Lyall, K., Hart, J. E., Just, A. C., Laden, F., et al. (2015). Autism Spectrum Disorder and Particulate Matter Air Pollution before, during, and after Pregnancy: A Nested Case-Control Analysis within the Nurses' Health Study II Cohort. Environ. Health Perspect. 123 (3), 264–270. doi:10.1289/ehp.1408133
Riediker, M., Zink, D., Kreyling, W., Oberdörster, G., Elder, A., Graham, U., et al. (2019). Particle Toxicology and Health - where Are We? Part. Fibre Toxicol. 16, 19. doi:10.1186/s12989-019-0302-8
Umezawa, M., Onoda, A., Korshunova, I., Jensen, A. C. Ø., Koponen, I. K., Jensen, K. A., et al. (2018). Maternal Inhalation of Carbon Black Nanoparticles Induces Neurodevelopmental Changes in Mouse Offspring. Part. Fibre Toxicol. 15, 36. doi:10.1186/s12989-018-0272-2
Wright, R. J., Hsu, H.-H. L., Chiu, Y.-H. M., Coull, B. A., Simon, M. C., Hudda, N., et al. (2021). Prenatal Ambient Ultrafine Particle Exposure and Childhood Asthma in the Northeastern United States. Am. J. Respir. Crit. Care Med. 204 (7), 788–796. doi:10.1164/rccm.202010-3743oc
Keywords: nanomaterials, fine particle matter (PM2.5), maternal exposure, infertility, neurotoxicity, immunotoxicity, epigenetics, antioxidant
Citation: Umezawa M, Onoda A and El-Sayed YS (2022) Editorial: Mechanisms of Developmental and Reproductive Toxicology of Ultrafine and Nano-Sized Particles. Front. Toxicology 4:853506. doi: 10.3389/ftox.2022.853506
Received: 12 January 2022; Accepted: 28 January 2022;
Published: 17 February 2022.
Edited and Reviewed by:
Karin Sørig Hougaard, National Research Centre for the Working Environment, DenmarkCopyright © 2022 Umezawa, Onoda and El-Sayed. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Masakazu Umezawa, masa-ume@rs.tus.ac.jp