Women’s participation in neurotoxicity research is fundamentally important to provide diverse perspectives during study design, execution, analysis, and interpretation of research. This includes a myriad of considerations from sex-specific vulnerabilities, environmental exposures, reproductive and developmental considerations, and underrepresentation in clinical trials, among others. Despite this, less the 30% of researchers worldwide identify as women. This Research Topic was inspired to highlight accomplished women researchers that wished to contribute their first or last author publications across the field of Neurotoxicology. By highlighting women in neurotoxicology, we also provide an opportunity for female researchers to serve as role models for the next-generation.
First, the manuscript by Carolina Caroso dos Santo Durão et al. examined exposure to environmental tobacco smoke (ETS) during the embryonic stage to see how it affected neuroinflammation in the adult mouse later in life. Multiple sclerosis (MS) is a neurological disorder involving inflammation and demyelination of the central nervous system and that has higher prevalence in women. A common mouse model of MS, called experimental autoimmune encephalomyelitis (EAE), was used in this study. In cell culture and EAE models, ETS exposure resulted in increased neuroinflammatory markers when compared to compressed air, including increased levels of proinflammatory cytokines IL6 and TNFα. Functionally, the ETS exposure resulted in significant worsening of EAE mouse clinical scores.
Next, a paper by Yaghoobi et al. investigated the developmental neurotoxicity potential of specific polychlorinated biphenyls (PCBs) in a zebrafish model. The researchers confirmed different PCB congeners exhibited varying potency in sensitizing ryanodine receptors (RYR) in zebrafish muscle. They found that a subset of these PCB congeners altered photomotor behavior in larval zebrafish, and the pattern of behavioral effects corresponded to the pattern of RYR sensitization, providing in vivo evidence supporting the hypothesis that RYR sensitization contributes to the developmental neurotoxicity of PCBs.
A review paper authored by Albrecht et al. summarizes effects of developmental lead (Pb) exposure on ethanol (EtOH) responses in Caenorhabditis elegans (C. elegans), a powerful model organism used to elucidate toxicant mechanisms. The authors describe morphological changes in dopamine synapses and dopamine-dependent behaviors, providing insights into the neurobiological mechanisms underlying the relationship between these neurotoxicants, and highlights the utility of C. elegans as a model for studying combined neurotoxicant effects.
Finally, a rat study by Reyes-Bravo et al. explored the role of chronic exposure to the herbicide atrazine to assess GABAergic and glutamatergic systems. After 1 year, there were changes in vertical activity episodes and several genes within the glutamatergic and GABAergic systems in the brain regions explored, which included striatum, nucleus accumbens, ventral midbrain, prefrontal cortex, and hippocampus. Of these, striatum had the most changes, followed by hippocampus. The results in this article spark interest to perform neurochemistry and neurobehavioral analysis especially in models of neurodegenerative disorders affecting basal ganglia.
Overall, the research studies uncover associations between environmental exposures and neurodevelopmental outcomes across several model systems and stages of development. The impact of environmental factors on neurological disease development has implications for the health of women across their lifespan in addition to their families, but also provides research communities valuable insight into the direction of future scientific endeavors Figure 1.
FIGURE 1
Statements
Author contributions
ML, AV, and SV were all guest editors for the Research Topic. ML wrote the editorial. AV and SV provided edits. All authors contributed to the article and approved the submitted version.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
women in STEM, neurotoxicity, neurotoxicology, women in science, women in neuroscience
Citation
Langley MR, Villalobos A and Vecchio S (2023) Editorial: Women in neurotoxicology: 2021. Front. Toxicol. 5:1248748. doi: 10.3389/ftox.2023.1248748
Received
27 June 2023
Accepted
15 August 2023
Published
04 September 2023
Volume
5 - 2023
Edited and reviewed by
Ellen Fritsche, Leibniz-Institut für Umweltmedizinische Forschung (IUF), Germany
Updates
Copyright
© 2023 Langley, Villalobos and Vecchio.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Monica Renee Langley, Langley.monica@mayo.edu
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.