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Curated by Giuseppe Giaccone (Cornell) and Sharon Pine (Univ. of Colorado), this collection showcases key advances in thoracic oncology: cancer biology, diagnostics, treatments, biomarkers, translational insights, early detection, and clinical care.

A tour of how DNA methylation, histone marks, chromatin remodeling, and non-coding RNAs shape tumors, plus tools like single-cell and multi-omics profiling, spatial epigenomics, long-read sequencing, and CRISPR-based epigenome editing.

We will attend the ESMO AI and Digital Oncology Congress in Berlin, 12–14 November 2025. Clinicians, researchers, and health leaders will share practical work to improve cancer diagnosis and care. We look forward to seeing you there.

From receptor biology to resistance, this review charts ERα/ERβ and GPER signaling, ESR1 hotspot mutations that stabilize agonist states and fuel endocrine resistance, and new therapies aimed at ERα mutants and GPER.

We are proud to sponsor a surgery-focused congress in Treviso, led by our Surgical Oncology Specialty Chief Editor, Dr. Francesco Giovinazzo. The program highlights advances in surgical oncology, minimally invasive care, robotics, AI, and AR.
Department of Cardiothoracic Surgery, Weill Cornell Medicine, Cornell University
New York, United States
Field Chief Editor
Frontiers in Oncology
Division of Medical Oncology, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus
Aurora, United States
Assistant Field Chief Editor
Frontiers in Oncology
University of Texas MD Anderson Cancer Center
Houston, United States
Specialty Chief Editor
Cardio-Oncology
Hôpitaux universitaires de Genève (HUG)
Genève, Switzerland
Specialty Chief Editor
Thoracic Oncology