Frontiers in Aging Neuroscience

Original Research

Published on 29 Aug 2025

Systemic inflammation versus clinical demographics: patient age surpasses the platelet-to-lymphocyte ratio in differentiating secondary trigeminal neuralgia

in Neuroinflammation and Neuropathy

Zihao Zhang
Qingpei Hao
Tao Wang
Shijun Peng
Xin Chang
Yuepeng Wang
Jia Ouyang
Ruen Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1658854

1,504 views

Mini Review

Published on 29 Aug 2025

Influence of biological sex on neuroinflammatory dynamics in the aging brain

in Neuroinflammation and Neuropathy

Ludmila Müller
Svetlana Di Benedetto
Viktor Müller

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1670175

3,864 views
6 citations

Mini Review

Published on 29 Aug 2025

Emerging biomarkers of postoperative delirium at the intersection of neuroinflammation and neurodegeneration

in Neuroinflammation and Neuropathy

Kun Leng
Mervyn Maze
Odmara L. Barreto Chang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1632947

4,092 views
4 citations

Original Research

Published on 29 Aug 2025

Association between shift work and brain age gap: a neuroimaging study using MRI-based brain age prediction algorithms

in Neurocognitive Aging and Behavior

Youjin Kim
Joon Yul Choi
Evgeny Petrovskiy
Wanhyung Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1650497

2,864 views

Original Research

Published on 26 Aug 2025

Longitudinal multimodal MRI analysis of lecanemab treatment in mild cognitive impairment: a pilot study of structural, perfusion, and microstructural changes

in Alzheimer's Disease and Related Dementias

Toshiya Takahashi
Dinh Ha Duy Thuy
Shingo Takenaka
Sayaka Ono
Maya Fukui
Yasushi Okada
Tomohiko Asada
Kan Niimi
Kaku Kimura
Akio Ikeda

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1651596

3,231 views

Original Research

Published on 26 Aug 2025

HDL from 36-h fasted participants potently promotes efflux of cholesteryl ester from activated microglia

in Neuroinflammation and Neuropathy

Joanne K. Agus
Oscar M. Muñoz Herrera
Christopher H. Rhodes
Jack Jingyuan Zheng
Chenghao Zhu
Maurice Wong
Xinyu Tang
Izumi Maezawa
Lee-Way Jin
Carlito B. Lebrilla

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1629496

2,540 views

Original Research

Published on 26 Aug 2025

The expression and association of MATK in chronic hypoperfusion patients with white matter hyperintensity

in Neurocognitive Aging and Behavior

Ming Zhao
Jiayue Zhang
Qianqian Yang
Lei Chen
Hongjian Shen
Yingyan Pu
Wei Wei
Yi Han
Ping Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1570482

1,782 views
1 citation

Brief Research Report

Published on 26 Aug 2025

Hand dexterity and mobility independently predict cognition in older adults: a multi-domain regression analysis

in Neurocognitive Aging and Behavior

Thomas Rudolf Schneider
Ansgar Felbecker
Ben von Mitzlaff
Gregor Weissofner
Sarah Meier
Patrick Eggenberger
Simon Annaheim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1624307

2,332 views
1 citation

Original Research

Published on 26 Aug 2025

Cognitive training gain transfer in cognitively healthy aging: per protocol results of the German AgeGain study

in Neurocognitive Aging and Behavior

Florian U. Fischer
Bianca Kollmann
Dominik Wolf
Alexandra Sebastian
Kristel Knaepen
David Riedel
Andreas Mierau
Nicolas Ruffini
Kristina Endres
Jennifer Winter

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1587395

2,213 views

Original Research

Published on 26 Aug 2025

Altered brain dynamics in post-stroke cognitive and motor dysfunction

in Neurocognitive Aging and Behavior

Xiaoying Liu
Guihua Song
Xiaoyun Zhuang
Ying Zhang
Xiaoyang Wang
Yin Qin

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1640378

1,955 views

Review

Published on 26 Aug 2025

Exercise as a multitarget therapy: modulating myokines, neurotrophins, and inflammation in Parkinson’s disease

in Parkinson’s Disease and Aging-related Movement Disorders

Wei-Qi Li
Jia-Hua Yang
Lu-Lu Liu
Song-Tao Ding
Bin Yu
Lin Jiang
Ning Yan
Han-Deng Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1580029

3,757 views

Original Research

Published on 26 Aug 2025

Cognitive flexibility in aging: the impact of age range and task difficulty on local switch costs in task switching

in Neurocognitive Aging and Behavior

Tara Radović
Sebastian Kübler
Rafael Mikolajczyk
Alexander Kluttig
Viktoria Maydych
Torsten Schubert

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1619441

2,415 views
1 citation

Review

Published on 25 Aug 2025

The manipulator behind “Scissors”: γ -secretase and its modulators in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Gao Ning
Xing Fan
Du Juan
Zhao wenxue
Wang Sijia
Chen Meinei
Dong Xiaolong
Qi Yiming

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1637671

3,987 views
2 citations

Correction

Published on 22 Aug 2025

Correction: A bibliometric analysis of the immune system and cognitive impairment: trends from 1985 to 2024

in Neuroinflammation and Neuropathy

Beibei Zou
Jinxi Xiang
Muhua Zhang
Jing Huang
Chao Feng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1675716

1,763 views

Original Research

Published on 22 Aug 2025

Moderating role of triglycerides in the relationship between amyloid-β, hippocampal atrophy, and cognitive decline in mild cognitive impairment and early Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Ji-Woo Seok
Kahye Kim
Soonjo Hwang
Kun Ho Lee
Jaeuk U. Kim

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1592341

2,556 views

Original Research

Published on 22 Aug 2025

Tooth loss impairs cognitive function in SAMP8 mice by aggravating pyroptosis of microglia via the cGAS/STING pathway

in Neurocognitive Aging and Behavior

Xu Sun
Yunping Lu
Jiangqi Hu
Shixiang Meng
Xiaoyu Wang
Qingsong Jiang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1628520

2,561 views
2 citations

Review

Published on 20 Aug 2025

Pathophysiological insights and therapeutic developments in age-related hearing loss: a narrative review

in Cellular and Molecular Mechanisms of Brain-aging

Shichu Sun
Qi Zhao
Haojia He
Yujia Liu
Yuchong Nie
You Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1657603

5,985 views
2 citations

Original Research

Published on 20 Aug 2025

Age-related trajectories of quality of life in community dwelling older adults: findings from the Survey of Health, Aging and Retirement in Europe (SHARE)

in Neurocognitive Aging and Behavior

Sarah Mendorf
Konstantin G. Heimrich
Hannah M. Mühlhammer
Tino Prell
Aline Schönenberg

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1632607

3,027 views
2 citations

Original Research

Published on 20 Aug 2025

Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Alexander Erofeev
Egor Vinokurov
Anastasia Bol’shakova
Ilya Bezprozvanny
Olga Vlasova

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1550673

2,566 views

Original Research

Published on 20 Aug 2025

Virtual reality navigation for the early detection of Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Sayuri Shima
Reiko Ohdake
Yasuaki Mizutani
Harutsugu Tatebe
Riki Koike
Atsushi Kasai
Epifanio Bagarinao
Kazuya Kawabata
Akihiro Ueda
Mizuki Ito

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1571429

3,698 views

Original Research

Published on 20 Aug 2025

Effectiveness of computer-assisted cognitive training on cognitive function and activities of daily living in patients with post-stroke cognitive impairment

in Neurocognitive Aging and Behavior

Xiaoyang Feng
Xiaolin Sun
Jia Liu
Yan Li
Yunhai Yao
Jianming Fu
Xudong Gu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1590783

2,495 views

Systematic Review

Published on 19 Aug 2025

Traditional Chinese exercises for motor symptoms and mobility in patients with Parkinson's disease: a systematic review and meta-analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Fumei Yuan
Hong Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1612913

2,541 views
1 citation

Editorial

Published on 19 Aug 2025

Editorial: The open challenges of cognitive frailty: risk factors, neuropsychological profiles and psychometric assessment for healthy aging

in Neurocognitive Aging and Behavior

Simone Varrasi
Sabrina Castellano
Daniele Magistro

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1679406

1,521 views
1 citation

Brief Research Report

Published on 19 Aug 2025

Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging

in Cellular and Molecular Mechanisms of Brain-aging

Viana Q. Pham
Melike Tutunculer
Halah Al-Dulaimi
Daniel Ardjmand
William Fleischmann
Tomas P. Bachor
Allison W. Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1634283

3,076 views

7,808 articles

articles

Systemic inflammation versus clinical demographics: patient age surpasses the platelet-to-lymphocyte ratio in differentiating secondary trigeminal neuralgia

Influence of biological sex on neuroinflammatory dynamics in the aging brain

Emerging biomarkers of postoperative delirium at the intersection of neuroinflammation and neurodegeneration

Association between shift work and brain age gap: a neuroimaging study using MRI-based brain age prediction algorithms

Longitudinal multimodal MRI analysis of lecanemab treatment in mild cognitive impairment: a pilot study of structural, perfusion, and microstructural changes

HDL from 36-h fasted participants potently promotes efflux of cholesteryl ester from activated microglia

The expression and association of MATK in chronic hypoperfusion patients with white matter hyperintensity

Hand dexterity and mobility independently predict cognition in older adults: a multi-domain regression analysis

Cognitive training gain transfer in cognitively healthy aging: per protocol results of the German AgeGain study

Altered brain dynamics in post-stroke cognitive and motor dysfunction

Exercise as a multitarget therapy: modulating myokines, neurotrophins, and inflammation in Parkinson’s disease

Cognitive flexibility in aging: the impact of age range and task difficulty on local switch costs in task switching

The manipulator behind “Scissors”: γ -secretase and its modulators in Alzheimer’s disease

Correction: A bibliometric analysis of the immune system and cognitive impairment: trends from 1985 to 2024

Moderating role of triglycerides in the relationship between amyloid-β, hippocampal atrophy, and cognitive decline in mild cognitive impairment and early Alzheimer’s disease

Tooth loss impairs cognitive function in SAMP8 mice by aggravating pyroptosis of microglia via the cGAS/STING pathway

Pathophysiological insights and therapeutic developments in age-related hearing loss: a narrative review

Age-related trajectories of quality of life in community dwelling older adults: findings from the Survey of Health, Aging and Retirement in Europe (SHARE)

Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer’s disease

Virtual reality navigation for the early detection of Alzheimer’s disease

Effectiveness of computer-assisted cognitive training on cognitive function and activities of daily living in patients with post-stroke cognitive impairment

Traditional Chinese exercises for motor symptoms and mobility in patients with Parkinson's disease: a systematic review and meta-analysis

Editorial: The open challenges of cognitive frailty: risk factors, neuropsychological profiles and psychometric assessment for healthy aging

Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging