Frontiers in Aging Neuroscience

Original Research

Published on 16 Dec 2025

Pharmacologically increasing O-GlcNAcylation increases complexity of astrocytes in the dentate gyrus of TgF344-AD rats

in Alzheimer's Disease and Related Dementias

Melissa L. Garcia
Adam R. Denton
Nateka L. Jackson
Michael D. Scofield
Lori L. McMahon

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1690410

1,774 views

Original Research

Accepted on 15 Dec 2025

ParkXplainer: An Interpretable Ensemble Learning Driven Approach for Hand-drawn Image based Early Parkinson's Detection using Grad-CAM

in Parkinson’s Disease and Aging-related Movement Disorders

Gayatri Saxena
Seema Bawa
Rohit Ahuja

Frontiers in Aging Neuroscience

241 views

Systematic Review

Published on 15 Dec 2025

The efficacy versus evidence quality of multicompomnent exercise for cognitive health in older adults: an umbrella review

in Alzheimer's Disease and Related Dementias

Weibao Liang
Chuannan Liu
Xujie Yan
Shuting Xu
Jianmin Dai
Wenbai Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1719179

1,171 views

Systematic Review

Published on 15 Dec 2025

Transcranial stimulation combined with four rehabilitation therapies for gait and motor function in Parkinson’s disease: a network meta-analysis of 23 RCTs

in Parkinson’s Disease and Aging-related Movement Disorders

Dongyue Li
Xinyu Lin
Haojie Li
Jian Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1670825

1,331 views

Original Research

Published on 15 Dec 2025

HALP, PIV, and SII as novel composite inflammatory indices for early detection and severity assessment of Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Chao Huang
Chenxi Lu
Shuai Liu
Fanshu Dai
Dilraba Mahmut
Hezhen Gao
Yong Ji
Biao Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1711176

1,167 views

Mini Review

Published on 12 Dec 2025

Pterostilbene restores mitochondrial retrograde signaling to activate protective stress responses in Parkinson’s disease

in Parkinson’s Disease and Aging-related Movement Disorders

Fanshuai Zeng
Wei Li
Liyue Yang
Lu Yao
Xinna Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1692777

1,744 views

Original Research

Published on 12 Dec 2025

Association between motor symptom severity and urinary dysfunction in Parkinson’s disease: a retrospective study

in Parkinson’s Disease and Aging-related Movement Disorders

Jun Seok Lee
Joonsang Yoo
Nak-Hoon Son
Hye Jin Byun
Sooyeoun You

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1688656

1,175 views

Review

Published on 12 Dec 2025

Parkinson’s disease physiopathology—beyond the α-synuclein aggregation: a narrative review

in Parkinson’s Disease and Aging-related Movement Disorders

Victor Fellipe Bispo Macedo
Vanessa Karine Bispo Macedo
Jorge Artur Peçanha de Miranda Coelho
Alana Madeiro de Melo Barboza

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1664269

1,863 views

Original Research

Published on 12 Dec 2025

Challenges in neuropsychological improvement after shunt surgery for idiopathic normal pressure hydrocephalus

in Neurocognitive Aging and Behavior

Ondřej Rýdlo
Adéla Bubeníková
Petr Skalický
Klára Häcklová
Robért Leško
Aleš Vlasák
Hana Georgi
Ondřej Bradáč

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1725486

1,431 views

Original Research

Published on 11 Dec 2025

Associations between the red blood cell distribution width and 30-day mortality in critically ill patients with delirium: a retrospective study using the MIMIC-IV database

in Neuroinflammation and Neuropathy

Songmei Ma
Lin Lin
Shuwen Zheng
Zhenjing Liu
Li Kong
Haiyun Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1599858

1,476 views

Systematic Review

Published on 11 Dec 2025

Machine learning methods for the detection and prediction of cognitive impairment in Parkinson’s disease: a systematic review and meta-analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Hong Jiang
Xinling Yang
Wenxing Wang
Lin Jiang
Xiao’e Jiang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1704039

1,311 views

Original Research

Published on 10 Dec 2025

Exploring the Mahuang Fuzi Xixin Decoction’s mechanism for treating Alzheimer’s disease using molecular docking and network pharmacology

in Alzheimer's Disease and Related Dementias

Che Chen
Qianfeng Shao
Sheng Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1688316

1,302 views

Original Research

Published on 10 Dec 2025

Prognostic value of endothelial activation and stress index in mechanical thrombectomy for patients with acute ischemic stroke

in Neuroinflammation and Neuropathy

Xiaohua Zhu
Yunnan Lu
Yaojia Xu
Yongxin Li
Qingyong Dai
Xia Chang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1683690

1,039 views

Original Research

Published on 10 Dec 2025

Amyloid pathology modulates the relationship between subsyndromal symptomatic depression and tau accumulation in non-demented older adults

in Alzheimer's Disease and Related Dementias

Jiahe Bai
Xiaonan Wei
Hongchun Wei
Yaojun Tai
Min Kong
Maowen Ba
Chunhua Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1679285

1,003 views

Original Research

Published on 10 Dec 2025

Safety and efficacy of extracranial vertebral artery stenting in elderly patients with symptomatic vertebral artery stenosis

in Neuroinflammation and Neuropathy

Miao Wu
Zhiyong Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1667157

957 views

Original Research

Published on 09 Dec 2025

Character-level linguistic biomarkers for precision assessment of cognitive decline: a symbolic recurrence approach

in Neurocognitive Aging and Behavior

Kevin Mekulu
Faisal Aqlan
Hui Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1681124

1,001 views
1 citation

Systematic Review

Published on 09 Dec 2025

The EEG analysis and identification of Alzheimer's disease: a review

in Alzheimer's Disease and Related Dementias

Jinying Bi
Fei Wang
Fangzhou Hu
Shuai Han
Yuting Wang
Zhijian Fu
Xin Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1686628

1,675 views

Original Research

Published on 09 Dec 2025

Enhanced Parkinson's disease prediction using LDEFS feature selection and Mamdani fuzzy neural network

in Parkinson’s Disease and Aging-related Movement Disorders

M. Vijayalakshmi
B. Dhiyanesh
D. Viji
P. Saranya

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1665590

841 views

Brief Research Report

Published on 09 Dec 2025

The cerebellar-related cognitive function is sensitive to aging: implications for early detection

in Neurocognitive Aging and Behavior

Qianying Ma
Min Pu
Meijia Li
Ling Liu
Ruilin Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1679443

936 views

Original Research

Published on 08 Dec 2025

A nomogram based on coagulation markers for predicting meige syndrome risk

in Parkinson’s Disease and Aging-related Movement Disorders

Yuanyuan Chen
Yuehua Sun
Xinyu Zhang
Yang Chen
Shuai Zhao
Mengyao Shi
Xuefeng Lv
Wenping Lian
Zhongquan Wang
Yongjun Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1665276

1,403 views

Original Research

Published on 08 Dec 2025

Clinical analysis of sarcopenia prevalence and its influencing factors in patients with Parkinson’s disease

in Parkinson’s Disease and Aging-related Movement Disorders

Remi Morimoto
Kazuo Kitagawa
Kenichi Todo
Mutsumi Iijima

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1718723

1,352 views

Original Research

Published on 08 Dec 2025

Cognitive impairment and dependency in activities of daily living: a cross-lagged analysis

in Neurocognitive Aging and Behavior

Xuewei Fu
Shuming Ji
Jiafeng Li
Ting Chen
Xuhuan Liu
Weihong Kuang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1663237

1,134 views

Original Research

Published on 08 Dec 2025

The impact of neighborhood environment on physical activity among older adults: chain mediating roles of self-efficacy and outcome expectations

in Neurocognitive Aging and Behavior

Lei Ying
Qingqing Yang
Jizhe Yu
Xiaoyun Liao
Wenming Fan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1730899

920 views

Original Research

Published on 05 Dec 2025

Machine learning-based early screening of mild cognitive impairment using nutrition-related biomarkers and functional indicators

in Alzheimer's Disease and Related Dementias

Ling Yuan
Yao Zhang
Yiwen Wu
Anke Zhang
He Bai
Mengyao He
Zhaoxin Wang
Liqiang Zheng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1641690

1,434 views

7,799 articles

articles

Pharmacologically increasing O-GlcNAcylation increases complexity of astrocytes in the dentate gyrus of TgF344-AD rats

ParkXplainer: An Interpretable Ensemble Learning Driven Approach for Hand-drawn Image based Early Parkinson's Detection using Grad-CAM

The efficacy versus evidence quality of multicompomnent exercise for cognitive health in older adults: an umbrella review

Transcranial stimulation combined with four rehabilitation therapies for gait and motor function in Parkinson’s disease: a network meta-analysis of 23 RCTs

HALP, PIV, and SII as novel composite inflammatory indices for early detection and severity assessment of Alzheimer’s disease

Pterostilbene restores mitochondrial retrograde signaling to activate protective stress responses in Parkinson’s disease

Association between motor symptom severity and urinary dysfunction in Parkinson’s disease: a retrospective study

Parkinson’s disease physiopathology—beyond the α-synuclein aggregation: a narrative review

Challenges in neuropsychological improvement after shunt surgery for idiopathic normal pressure hydrocephalus

Associations between the red blood cell distribution width and 30-day mortality in critically ill patients with delirium: a retrospective study using the MIMIC-IV database

Machine learning methods for the detection and prediction of cognitive impairment in Parkinson’s disease: a systematic review and meta-analysis

Exploring the Mahuang Fuzi Xixin Decoction’s mechanism for treating Alzheimer’s disease using molecular docking and network pharmacology

Prognostic value of endothelial activation and stress index in mechanical thrombectomy for patients with acute ischemic stroke

Amyloid pathology modulates the relationship between subsyndromal symptomatic depression and tau accumulation in non-demented older adults

Safety and efficacy of extracranial vertebral artery stenting in elderly patients with symptomatic vertebral artery stenosis

Character-level linguistic biomarkers for precision assessment of cognitive decline: a symbolic recurrence approach

The EEG analysis and identification of Alzheimer's disease: a review

Enhanced Parkinson's disease prediction using LDEFS feature selection and Mamdani fuzzy neural network

The cerebellar-related cognitive function is sensitive to aging: implications for early detection

A nomogram based on coagulation markers for predicting meige syndrome risk

Clinical analysis of sarcopenia prevalence and its influencing factors in patients with Parkinson’s disease

Cognitive impairment and dependency in activities of daily living: a cross-lagged analysis

The impact of neighborhood environment on physical activity among older adults: chain mediating roles of self-efficacy and outcome expectations

Machine learning-based early screening of mild cognitive impairment using nutrition-related biomarkers and functional indicators