Frontiers in Aging Neuroscience

Systematic Review

Published on 05 Dec 2025

The effect of mind–body exercise on cognitive function and neuroplasticity in elderly people with mild cognitive impairment: a systematic review and meta-analysis

in Neurocognitive Aging and Behavior

Huifang Tian
Xi Yang
Jiahuan Li
Yuqi Cheng
Shui Tian
Fanfan Meng
Qinqin Zhu
Ying Shen
Tong Wang
Chuan Guo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1683808

1,793 views
1 citation

Original Research

Published on 04 Dec 2025

Peripheral CHI3L1 expression is associated with APOE ε4 status in early-onset Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Anja Steinmaurer
Lina Breit
Elisabeth Stögmann
Theresa König

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1730319

1,482 views

Original Research

Published on 04 Dec 2025

Assessing neurocognitive functioning among adults ageing with and without HIV at the Kenyan Coast: measurement issues and correlates

in Neurocognitive Aging and Behavior

Patrick N. Mwangala
Carophine Nasambu
Ryan G. Wagner
Mihaela Duta
Gaia Scerif
Charles R. Newton
Amina Abubakar

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1702869

1,137 views

Editorial

Published on 04 Dec 2025

Editorial: Sex-dependent modulation of neuroinflammation in the aging brain

in Neuroinflammation and Neuropathy

Yu-Min Kuo
Shun-Fen Tzeng
Celia Giulietta Fernandez

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1745448

996 views

Perspective

Published on 03 Dec 2025

Rethinking the diagnosis of primary progressive aphasia: current challenges and future directions

in Alzheimer's Disease and Related Dementias

Joël Macoir
Monica Lavoie
Guillaume Duboisdindien
Robert Laforce

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1736855

1,473 views

Review

Published on 03 Dec 2025

The ubiquitin-proteasome system in Alzheimer’s disease: mechanism of action and current status of treatment

in Alzheimer's Disease and Related Dementias

Shanshan Jia
Quan Li
Xue Rui
Wen Qin
Wenhui Zhang
Jinjin Dou
Xiwu Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1730206

1,643 views

Original Research

Published on 03 Dec 2025

Abnormal subthalamic nucleus functional connectivity and machine learning classification in Parkinson’s disease: a multisite functional magnetic resonance imaging study

in Parkinson’s Disease and Aging-related Movement Disorders

Bin Qin
Yisi Tang
Huixun Qin
Wen Gao
Shusheng Liao
Mingxiu Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1695806

933 views

Original Research

Published on 03 Dec 2025

Anatomically refined entorhinal cortex segmentation improves MRI-based early diagnosis of Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Yongha Gi
Sangyoon Park
Hyungjin Lim
Jeongwon Lee
A. Hyun Jung
Seol-Hee Baek
Jong Hyun Kim
Byung-Jo Kim
Myonggeun Yoon

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1682106

1,364 views

Opinion

Published on 03 Dec 2025

The mechanosensitive Piezo1 channel mechanism of Alzheimer's disease and implications for the development of therapeutic or early detection strategies

in Alzheimer's Disease and Related Dementias

Mo Zhang
Huifang Hou
Hui Li
Xinyang Bai
Huina Song
Lu Wang
Lin-Hua Jiang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1707659

1,209 views

Original Research

Published on 03 Dec 2025

Early detection of mild cognitive impairment utilizing ocular biomarker-based risk scoring nomogram

in Alzheimer's Disease and Related Dementias

Mohammed Seid Hussen
Bess Yin-Hung Lam
Wei Gao
Liping Zhou
Kai Yip Choi
Henry Ho-lung Chan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1669948

1,427 views

Original Research

Published on 03 Dec 2025

Validation of the robustness of blood-based biomarkers for predicting amyloid-β positivity in Chinese populations

in Alzheimer's Disease and Related Dementias

Ying Wang
Liang Cui
Feng-Feng Pan
Zhen Zhang
Lin Huang
Ya Miao
Yi-Hui Guan
Qi-Hao Guo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1660755

1,610 views

Original Research

Accepted on 02 Dec 2025

Dexmedetomidine Ameliorates Cognitive and Affective Deficits by Modulating Neuroinflammation and Neurogenesis in an Alzheimer's Disease Mouse Model

in Alzheimer's Disease and Related Dementias

Mai Li
Chanyuan An
Xin Wang
Minghe Ren
Shiyu Liu
Ruixin Chen
Yuyan Guo
Jun Wang
Yulang Fei
Dafei Ma

Frontiers in Aging Neuroscience

1,349 views

Correction

Published on 02 Dec 2025

Correction: Visual attention during non-immersive virtual reality balance training in older adults with mild to moderate cognitive impairment: an eye-tracking study

in Neurocognitive Aging and Behavior

Marcos Maldonado-Díaz
Gonzalo Jara-Vargas
Felipe González-Seguel

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1737079

1,313 views

Original Research

Published on 02 Dec 2025

Agricultural or gardening physical activity may slow neurovascular aging and prevent stroke and dementia: an experimental and cross-sectional study

in Alzheimer's Disease and Related Dementias

Kiyoshi Kikuchi
Seiya Takada
Shotaro Otsuka
Kazuki Nakanishi
Harutoshi Sakakima
Hyuma Makizako
Nobuhiro Tahara
Hisaaki Uchikado
Naoto Shiomi
Satomi Ooba

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1676259

1,353 views

Original Research

Published on 02 Dec 2025

Correlation between cerebral small vessel disease and postural instability/gait difficulty subtype in Parkinson’s disease patients

in Parkinson’s Disease and Aging-related Movement Disorders

Yingchao Ge
Wa Zhao
Xiaorong Xu
Wenchao Qiu
Peiting Liu
Minghui Zhao
Yongqing Cheng
Shouru Xue

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1686214

1,139 views

Review

Published on 01 Dec 2025

The locus coeruleus, a blue spot for early diagnosis and prognosis of Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Fatemeh Farahani
Christelle Anaclet
Hossein Azizi
Heinrich S. Gompf

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1632236

2,053 views

Original Research

Published on 01 Dec 2025

Sarcopenia and cognitive impairment: a multidimensional study of clinical associations, shared genetics, and causal links

in Neurocognitive Aging and Behavior

Kemeng Zhang
Sui Huang
Mengchen Liu
Yi Zhang
Wenhan Li
Bijin Luo
Ping He

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1708170

1,484 views

Review

Published on 01 Dec 2025

How is the brain affected by metabolically healthy or unhealthy obesity in adulthood and elderly? A narrative review of neuroimaging and neurocognitive findings

in Neurocognitive Aging and Behavior

Antonietta Pepe
Asieh Amousoltani Arani
Francesca Bracone
Augusto Di Castelnuovo
Loreto Muñoz-Venegas
Chiara Cerletti
Giovanni de Gaetano
Maria Benedetta Donati
Licia Iacoviello
Alessandro Gialluisi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1616303

2,092 views

Original Research

Published on 01 Dec 2025

An investigation on Alzheimer’s disease with obstructive sleep apnea: alterations of cognitive function, roles of cyclin-dependent kinase 5 and changes of brain structure

in Alzheimer's Disease and Related Dementias

Dongmei Luo
Tenghong Lian
Ning Wei
Peng Guo
Mingyue He
Yanan Zhang
Yue Huang
Gaifen Liu
Jinghui Li
Jing Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1552535

1,555 views

Original Research

Published on 01 Dec 2025

Impact of aging on the central and enteric nervous system in a Parkinson’s disease mouse model

in Parkinson’s Disease and Aging-related Movement Disorders

Solène Pradeloux
Morgane M. André
Maélie Fréchette
Mathilde Drolet
Catherine Fontaine-Lavallée
Mélissa Côté
Katherine Coulombe
Marie Rieux
Frédéric Calon
Denis Soulet

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1576325

1,538 views

Review

Published on 01 Dec 2025

Research progress on the role of microbiome-immune-neurotransmitter network in post-stroke sleep disorders

in Neuroinflammation and Neuropathy

Wanting Shi
Li Wu
Qiong Qin
Yanjing Li
Wei Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1694709

1,869 views

Original Research

Published on 01 Dec 2025

Construction and validation of a cognitive frailty risk prediction model for elderly patients with colorectal cancer

in Neurocognitive Aging and Behavior

Yu Wang
Li Wang
Yunhong Du
Xiaoye Ma
Lili Sun
Xiujie Zhang
Wenli Rong
Jianwei Li
Yao Shi
Wei Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1692414

1,330 views

Original Research

Published on 01 Dec 2025

Global, regional, and national burden of Alzheimer’s disease and other dementias from 1990 to 2021: findings from the Global Burden of Disease Study 2021

in Alzheimer's Disease and Related Dementias

Yinglei Duan
Chongfang Han
Hua Zheng
Jing Yu
Min Luo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1678212

1,934 views

Review

Published on 28 Nov 2025

Development and emerging trends in gastrointestinal dysfunction of Parkinson’s disease: a decade-long bibliometric analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Yujia Sun
Haoyu Yang
Junfeng Zhang
Shan Cong
Lin Wang
Tao Yu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1712302

1,898 views

7,799 articles

articles

The effect of mind–body exercise on cognitive function and neuroplasticity in elderly people with mild cognitive impairment: a systematic review and meta-analysis

Peripheral CHI3L1 expression is associated with APOE ε4 status in early-onset Alzheimer’s disease

Assessing neurocognitive functioning among adults ageing with and without HIV at the Kenyan Coast: measurement issues and correlates

Editorial: Sex-dependent modulation of neuroinflammation in the aging brain

Rethinking the diagnosis of primary progressive aphasia: current challenges and future directions

The ubiquitin-proteasome system in Alzheimer’s disease: mechanism of action and current status of treatment

Abnormal subthalamic nucleus functional connectivity and machine learning classification in Parkinson’s disease: a multisite functional magnetic resonance imaging study

Anatomically refined entorhinal cortex segmentation improves MRI-based early diagnosis of Alzheimer’s disease

The mechanosensitive Piezo1 channel mechanism of Alzheimer's disease and implications for the development of therapeutic or early detection strategies

Early detection of mild cognitive impairment utilizing ocular biomarker-based risk scoring nomogram

Validation of the robustness of blood-based biomarkers for predicting amyloid-β positivity in Chinese populations

Dexmedetomidine Ameliorates Cognitive and Affective Deficits by Modulating Neuroinflammation and Neurogenesis in an Alzheimer's Disease Mouse Model

Correction: Visual attention during non-immersive virtual reality balance training in older adults with mild to moderate cognitive impairment: an eye-tracking study

Agricultural or gardening physical activity may slow neurovascular aging and prevent stroke and dementia: an experimental and cross-sectional study

Correlation between cerebral small vessel disease and postural instability/gait difficulty subtype in Parkinson’s disease patients

The locus coeruleus, a blue spot for early diagnosis and prognosis of Alzheimer’s disease

Sarcopenia and cognitive impairment: a multidimensional study of clinical associations, shared genetics, and causal links

How is the brain affected by metabolically healthy or unhealthy obesity in adulthood and elderly? A narrative review of neuroimaging and neurocognitive findings

An investigation on Alzheimer’s disease with obstructive sleep apnea: alterations of cognitive function, roles of cyclin-dependent kinase 5 and changes of brain structure

Impact of aging on the central and enteric nervous system in a Parkinson’s disease mouse model

Research progress on the role of microbiome-immune-neurotransmitter network in post-stroke sleep disorders

Construction and validation of a cognitive frailty risk prediction model for elderly patients with colorectal cancer

Global, regional, and national burden of Alzheimer’s disease and other dementias from 1990 to 2021: findings from the Global Burden of Disease Study 2021

Development and emerging trends in gastrointestinal dysfunction of Parkinson’s disease: a decade-long bibliometric analysis