Frontiers in Aging Neuroscience

Original Research

Published on 31 Dec 2025

Altered resting-state functional connectivity of raphe nucleus is associated with tremor in Parkinson’s disease

Qianyi Zheng
Dongling Zhang
Junyan Sun
Junling Wang
Lili Chen
Xuemei Wang
Tao Wu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1709735

1,817 views

Original Research

Published on 29 Dec 2025

Integrated bioinformatics analysis reveals Netrin-1 as a key molecular link between Parkinson’s disease and heart failure

Zhen Ni
Gaoge Wang
Yingyan Li
Huan Chen
Hongwei Hou
Qingyuan Hu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1709337

1,353 views

Original Research

Published on 19 Dec 2025

Treadmill exercise alleviates Alzheimer’s disease pathologies in APP/PS1 mice through modulation of microglial glucose metabolic reprogramming

Fei Liang
Feng Sun
Cuijun Guo
Huacong Zhong

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1734837

2,643 views

Original Research

Published on 18 Dec 2025

Body composition and cognitive function in Chinese rural adults: an exploratory factor analysis and network analysis

Lei Wang
Hongjuan Liu
Xianfeng Meng
Zhengjiao Tuo
Yuning Zhou
Peiyi Wu
Enhui Wang
Yuxin Shen
Ziyi Wang
Caijiu Deng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1722050

1,117 views

Review

Published on 17 Dec 2025

The application of fecal microbiota transplantation in Parkinson’s disease

Boyan Wang
Di Ma
Na Li
Tianfei Luo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1713899

1,764 views

Review

Published on 17 Dec 2025

Autophagy-mediated regulation of neutrophil inflammatory responses and its relevance to central nervous system diseases

Yuliu Li
Yiqing Tan
Wei Zuo

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1702993

907 views

Original Research

Published on 16 Dec 2025

Hippocampal T1WI radiomics- and clinical feature-based models for predicting early mild cognitive impairment in secondary hydrocephalus

Xiaofeng Wang
Ziao Xu
Bohang Liu
Xuefei Ji
Liao Guan
Lei Ye
Hongwei Cheng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1672254

1,431 views

Original Research

Published on 16 Dec 2025

Qi-Fu-Yin ameliorates physiological frailty in male 5xFAD mice through remodeling the gut microbiota and modulating the cerebral cortex metabolism

Yitong Xiao
He Li
Xinyuan Han
Yixiao Liu
Jiayu Sun
Chenxi Sun
Yichen Wang
Tianyuan Ye
Xiaorui Cheng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1622286

1,290 views

Original Research

Published on 16 Dec 2025

Pharmacologically increasing O-GlcNAcylation increases complexity of astrocytes in the dentate gyrus of TgF344-AD rats

Melissa L. Garcia
Adam R. Denton
Nateka L. Jackson
Michael D. Scofield
Lori L. McMahon

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1690410

1,821 views

Original Research

Published on 16 Dec 2025

A lightweight cerebrospinal fluid biomarker-based model for first-diagnosis prediction of Parkinson’s disease: model development, external validation, and local deployment

Xinchao Hu
Yu Liu
Yuan Cao
Chunli Wei
Kun Liu
Jing-Hua Yang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1723169

1,539 views

Original Research

Accepted on 15 Dec 2025

ParkXplainer: An Interpretable Ensemble Learning Driven Approach for Hand-drawn Image based Early Parkinson's Detection using Grad-CAM

Gayatri Saxena
Seema Bawa
Rohit Ahuja

Frontiers in Aging Neuroscience

241 views

Systematic Review

Published on 15 Dec 2025

The efficacy versus evidence quality of multicompomnent exercise for cognitive health in older adults: an umbrella review

Weibao Liang
Chuannan Liu
Xujie Yan
Shuting Xu
Jianmin Dai
Wenbai Huang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1719179

1,206 views

Systematic Review

Published on 15 Dec 2025

Transcranial stimulation combined with four rehabilitation therapies for gait and motor function in Parkinson’s disease: a network meta-analysis of 23 RCTs

Dongyue Li
Xinyu Lin
Haojie Li
Jian Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1670825

1,354 views

Original Research

Published on 15 Dec 2025

HALP, PIV, and SII as novel composite inflammatory indices for early detection and severity assessment of Alzheimer’s disease

Chao Huang
Chenxi Lu
Shuai Liu
Fanshu Dai
Dilraba Mahmut
Hezhen Gao
Yong Ji
Biao Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1711176

1,196 views

Mini Review

Published on 12 Dec 2025

Pterostilbene restores mitochondrial retrograde signaling to activate protective stress responses in Parkinson’s disease

Fanshuai Zeng
Wei Li
Liyue Yang
Lu Yao
Xinna Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1692777

1,781 views

Original Research

Published on 12 Dec 2025

Association between motor symptom severity and urinary dysfunction in Parkinson’s disease: a retrospective study

Jun Seok Lee
Joonsang Yoo
Nak-Hoon Son
Hye Jin Byun
Sooyeoun You

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1688656

1,212 views

Original Research

Published on 12 Dec 2025

Challenges in neuropsychological improvement after shunt surgery for idiopathic normal pressure hydrocephalus

Ondřej Rýdlo
Adéla Bubeníková
Petr Skalický
Klára Häcklová
Robért Leško
Aleš Vlasák
Hana Georgi
Ondřej Bradáč

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1725486

1,484 views

Review

Published on 12 Dec 2025

Parkinson’s disease physiopathology—beyond the α-synuclein aggregation: a narrative review

Victor Fellipe Bispo Macedo
Vanessa Karine Bispo Macedo
Jorge Artur Peçanha de Miranda Coelho
Alana Madeiro de Melo Barboza

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1664269

1,937 views

Original Research

Published on 11 Dec 2025

Associations between the red blood cell distribution width and 30-day mortality in critically ill patients with delirium: a retrospective study using the MIMIC-IV database

Songmei Ma
Lin Lin
Shuwen Zheng
Zhenjing Liu
Li Kong
Haiyun Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1599858

1,533 views

Systematic Review

Published on 11 Dec 2025

Machine learning methods for the detection and prediction of cognitive impairment in Parkinson’s disease: a systematic review and meta-analysis

Hong Jiang
Xinling Yang
Wenxing Wang
Lin Jiang
Xiao’e Jiang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1704039

1,338 views

Original Research

Published on 10 Dec 2025

Exploring the Mahuang Fuzi Xixin Decoction’s mechanism for treating Alzheimer’s disease using molecular docking and network pharmacology

Che Chen
Qianfeng Shao
Sheng Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1688316

1,357 views

Original Research

Published on 10 Dec 2025

Prognostic value of endothelial activation and stress index in mechanical thrombectomy for patients with acute ischemic stroke

Xiaohua Zhu
Yunnan Lu
Yaojia Xu
Yongxin Li
Qingyong Dai
Xia Chang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1683690

1,062 views

Original Research

Published on 10 Dec 2025

Amyloid pathology modulates the relationship between subsyndromal symptomatic depression and tau accumulation in non-demented older adults

Jiahe Bai
Xiaonan Wei
Hongchun Wei
Yaojun Tai
Min Kong
Maowen Ba
Chunhua Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1679285

1,023 views

Original Research

Published on 10 Dec 2025

Safety and efficacy of extracranial vertebral artery stenting in elderly patients with symptomatic vertebral artery stenosis

Miao Wu
Zhiyong Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1667157

974 views

7,808 Publications

volumes

Volume 17 - 2025

Altered resting-state functional connectivity of raphe nucleus is associated with tremor in Parkinson’s disease

Integrated bioinformatics analysis reveals Netrin-1 as a key molecular link between Parkinson’s disease and heart failure

Treadmill exercise alleviates Alzheimer’s disease pathologies in APP/PS1 mice through modulation of microglial glucose metabolic reprogramming

Body composition and cognitive function in Chinese rural adults: an exploratory factor analysis and network analysis

The application of fecal microbiota transplantation in Parkinson’s disease

Autophagy-mediated regulation of neutrophil inflammatory responses and its relevance to central nervous system diseases

Hippocampal T1WI radiomics- and clinical feature-based models for predicting early mild cognitive impairment in secondary hydrocephalus

Qi-Fu-Yin ameliorates physiological frailty in male 5xFAD mice through remodeling the gut microbiota and modulating the cerebral cortex metabolism

Pharmacologically increasing O-GlcNAcylation increases complexity of astrocytes in the dentate gyrus of TgF344-AD rats

A lightweight cerebrospinal fluid biomarker-based model for first-diagnosis prediction of Parkinson’s disease: model development, external validation, and local deployment

ParkXplainer: An Interpretable Ensemble Learning Driven Approach for Hand-drawn Image based Early Parkinson's Detection using Grad-CAM

The efficacy versus evidence quality of multicompomnent exercise for cognitive health in older adults: an umbrella review

Transcranial stimulation combined with four rehabilitation therapies for gait and motor function in Parkinson’s disease: a network meta-analysis of 23 RCTs

HALP, PIV, and SII as novel composite inflammatory indices for early detection and severity assessment of Alzheimer’s disease

Pterostilbene restores mitochondrial retrograde signaling to activate protective stress responses in Parkinson’s disease

Association between motor symptom severity and urinary dysfunction in Parkinson’s disease: a retrospective study

Challenges in neuropsychological improvement after shunt surgery for idiopathic normal pressure hydrocephalus

Parkinson’s disease physiopathology—beyond the α-synuclein aggregation: a narrative review

Associations between the red blood cell distribution width and 30-day mortality in critically ill patients with delirium: a retrospective study using the MIMIC-IV database

Machine learning methods for the detection and prediction of cognitive impairment in Parkinson’s disease: a systematic review and meta-analysis

Exploring the Mahuang Fuzi Xixin Decoction’s mechanism for treating Alzheimer’s disease using molecular docking and network pharmacology

Prognostic value of endothelial activation and stress index in mechanical thrombectomy for patients with acute ischemic stroke

Amyloid pathology modulates the relationship between subsyndromal symptomatic depression and tau accumulation in non-demented older adults

Safety and efficacy of extracranial vertebral artery stenting in elderly patients with symptomatic vertebral artery stenosis