Frontiers in Cardiovascular Medicine | Cardiovascular Genetics and Systems Medicine

Case Report

Accepted on 17 Mar 2025

Case report: A novel Variant of the TTN gene and Two other rare Variants in a Chinese patient with Dilated Cardiomyopathy

in Cardiovascular Genetics and Systems Medicine

Shan Han
Ying-Yi Zhang
Jie Geng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1527544

Original Research

Accepted on 03 Mar 2025

Identification of Candidate Cardiomyopathy Modifier Genes through Genome Sequencing and RNA Profiling

in Cardiovascular Genetics and Systems Medicine

Malene E Lindholm
Sarah Abramowitz
Daryl M Waggott
Megan E Grove
Frederick E Dewey
Cuiping Pan
Aleksandra Pavlovic
Ching Shang
Yong Huang
Leore Bensabath

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1546493

Original Research

Published on 27 Feb 2025

Myocardial dysfunction caused by MyBPC3 P459fs mutation in hypertrophic cardiomyopathy: evidence from multi-omics approaches and super-resolution imaging

in Cardiovascular Genetics and Systems Medicine

Yupeng Wu
Yuzhu Zhang
Qirui Zheng
Qiyuan Wang
Xingyu Fang
Zaihan Zhu
Jing Lu
Dandan Sun

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1529921

392 views

Original Research

Published on 24 Feb 2025

Comprehensive bioinformatics analysis of hub genes in ischemic heart failure and atrial fibrillation

in Cardiovascular Genetics and Systems Medicine

Meimei Zhou
Youkang Xu
Lili Zhang
Yushan Yang
Jiejiao Zheng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1499065

596 views

Review

Published on 19 Feb 2025

Modeling thoracic aortic genetic variants in the zebrafish: useful for predicting clinical pathogenicity?

in Cardiovascular Genetics and Systems Medicine

Andrew Prendergast
Mary B. Sheppard
Jakub K. Famulski
Stefania Nicoli
Sandip Mukherjee
Patrick Sips
John A. Elefteriades

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1480407

594 views

Editorial

Published on 04 Feb 2025

Editorial: Role of epigenetic modulations and transcription factor in cardiovascular disease and coronary artery spasm: mechanisms and interventions

in Cardiovascular Genetics and Systems Medicine

Ioanna Koniari
Nicholas G. Kounis
Ming-Yow Hung

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1546614

485 views

Original Research

Published on 03 Feb 2025

A case series of patients with cardiac amyloidosis evaluated at a Colombian university hospital

in Cardiovascular Genetics and Systems Medicine

Juan David López-Ponce de León
Santiago Granados-Álvarez
Juan Pablo Arango-Ibanez
Juan Manuel Montero Echeverri
Andrea Alejandra Arteaga Tobar
Andrea Facio-Lince Garcia
Yorlany Rodas Cortes
Juan Esteban Gómez-Mesa

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1487717

748 views

Case Report

Published on 20 Jan 2025

Case Report: Rare cardiovascular characteristics of tuberous sclerosis complex with novel TSC2 variant

in Cardiovascular Genetics and Systems Medicine

Zhiqin Du
Xiao Ma
Jianhua Li
Fang Yang
Yangfan Guo

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1464933

575 views

Case Report

Published on 20 Jan 2025

Case Report: A case of Tatton-Brown–Rahman syndrome featuring mitral annular disjunction and mitral valve prolapse due to a novel mutation site in the DNMT3A gene

in Cardiovascular Genetics and Systems Medicine

Zhong-jiao Xu
Ru-ming Shen
Wu-ming Hu
Lin-chun Lv
Zhen-hua Shi
Li Lin

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1507318

503 views

Review

Published on 13 Jan 2025

Advances of research in diabetic cardiomyopathy: diagnosis and the emerging application of sequencing

in Cardiovascular Genetics and Systems Medicine

Qianqian He
Ze Lai
Zhengyao Zhai
Beibei Zou
Yangkai Shi
Chao Feng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1501735

1,122 views

Original Research

Published on 13 Jan 2025

Identification of mitophagy-related key genes and their correlation with immune cell infiltration in acute myocardial infarction via bioinformatics analysis

in Cardiovascular Genetics and Systems Medicine

Zulong Sheng
Rui Zhang
Zhenjun Ji
Zhuyuan Liu
Yaqing Zhou

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1501608

900 views

Original Research

Published on 08 Jan 2025

DEPDC1B, CDCA2, APOBEC3B, and TYMS are potential hub genes and therapeutic targets for diagnosing dialysis patients with heart failure

in Cardiovascular Genetics and Systems Medicine

Wenwu Tang
Zhixin Wang
Xinzhu Yuan
Liping Chen
Haiyang Guo
Zhirui Qi
Ying Zhang
Xisheng Xie

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1442238

825 views

Original Research

Published on 06 Jan 2025

Enhanced fibrotic potential of COL1A1hiNR4A1low fibroblasts in ischemic heart revealed by transcriptional dynamics heterogeneity analysis at both bulk and single-cell levels

in Cardiovascular Genetics and Systems Medicine

Cheng Luo
Baoping Tan
Luoxiang Chu
Liqiang Chen
Xinglong Zhong
Yangyang Jiang
Yuluan Yan
Fanrui Mo
Hong Wang
Fan Yang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1460813

1,067 views

Original Research

Published on 03 Dec 2024

Protective effect of UDCA against IL-11- induced cardiac fibrosis is mediated by TGR5 signalling

in Cardiovascular Genetics and Systems Medicine

B. Reilly-O’Donnell
E. Ferraro
R. Tikhomirov
R. Nunez-Toldra
A. Shchendrygina
L. Patel
Y. Wu
A. L. Mitchell
A. Endo
L. Adorini

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1430772

5,028 views

Case Report

Published on 22 Nov 2024

Case Report: Diagnostic challenges in Fabry disease: misinterpreted obstructive hypertrophic cardiomyopathy and the role of enzyme replacement therapy

in Cardiovascular Genetics and Systems Medicine

Weili Cheng
Mingqiang Ao
Dinghu Xu
Yuqing Zhang
Qin Tao

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1479374

805 views
1 citation

Case Report

Published on 13 Nov 2024

Case Report: Allelic and biallelic variants in coagulation factor XI cause factor XI deficiency

in Cardiovascular Genetics and Systems Medicine

Chen Liang
Jie-Yuan Jin
Hai-Hong Shi
Hao-Xian Li
Lin-Lin Chen
Yang-Hui Zhang
Qin Wang
Qiu-Li Li
Rui-Man Li

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2024.1461899

759 views

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Articles

Case report: A novel Variant of the TTN gene and Two other rare Variants in a Chinese patient with Dilated Cardiomyopathy

Identification of Candidate Cardiomyopathy Modifier Genes through Genome Sequencing and RNA Profiling

Myocardial dysfunction caused by MyBPC3 P459fs mutation in hypertrophic cardiomyopathy: evidence from multi-omics approaches and super-resolution imaging

Comprehensive bioinformatics analysis of hub genes in ischemic heart failure and atrial fibrillation

Modeling thoracic aortic genetic variants in the zebrafish: useful for predicting clinical pathogenicity?

Editorial: Role of epigenetic modulations and transcription factor in cardiovascular disease and coronary artery spasm: mechanisms and interventions

A case series of patients with cardiac amyloidosis evaluated at a Colombian university hospital

Case Report: Rare cardiovascular characteristics of tuberous sclerosis complex with novel TSC2 variant

Case Report: A case of Tatton-Brown–Rahman syndrome featuring mitral annular disjunction and mitral valve prolapse due to a novel mutation site in the DNMT3A gene

Advances of research in diabetic cardiomyopathy: diagnosis and the emerging application of sequencing

Identification of mitophagy-related key genes and their correlation with immune cell infiltration in acute myocardial infarction via bioinformatics analysis

DEPDC1B, CDCA2, APOBEC3B, and TYMS are potential hub genes and therapeutic targets for diagnosing dialysis patients with heart failure

Enhanced fibrotic potential of COL1A1hiNR4A1low fibroblasts in ischemic heart revealed by transcriptional dynamics heterogeneity analysis at both bulk and single-cell levels

Protective effect of UDCA against IL-11- induced cardiac fibrosis is mediated by TGR5 signalling

Case Report: Diagnostic challenges in Fabry disease: misinterpreted obstructive hypertrophic cardiomyopathy and the role of enzyme replacement therapy

Case Report: Allelic and biallelic variants in coagulation factor XI cause factor XI deficiency