Frontiers in Cardiovascular Medicine | Cardiovascular Genetics and Systems Medicine

Case Report

Published on 15 Apr 2026

Case Report: A young man with mitochondrial disease: intellectual impairment and myocardial hypertrophy

in Cardiovascular Genetics and Systems Medicine

Xiao Luo
Ling Li
Gaofeng Su

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1802202

184 views

Review

Published on 15 Apr 2026

Transcriptional regulation in cardiovascular aging

in Cardiovascular Genetics and Systems Medicine

Yiguang Fan
Chao Song
Fangnan Feng
Qing Xun
Yuhao Lu
Chunquan Li

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1752877

142 views

Case Report

Accepted on 13 Apr 2026

Case report: Typical triad of Danon disease caused by a LAMP2 splice-donor variant with multi-level functional validation

in Cardiovascular Genetics and Systems Medicine

Yang Hu
Shi Jie Liu
qian Liu
Hui Peng Su
Li Yang
Lu Lu Gan
Jin Ting Zhang
Yangfan Guo
Yan He

Frontiers in Cardiovascular Medicine

Case Report

Published on 13 Apr 2026

Case Report: Severe protein S deficiency unmasks a cryptic PROC mutation with normal activity, triggering life-threatening pulmonary thromboembolism

in Cardiovascular Genetics and Systems Medicine

Yafei Liu
Binbin Zhou
Jianjian Xue
Wei Zhang
Jiewei Liu

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1804812

128 views

Case Report

Accepted on 07 Apr 2026

A Novel GDF1 Frameshift Mutation in a Young Adult with Right Coronary Artery Hypoplasia and Myocardial Bridging: A Case Report

in Cardiovascular Genetics and Systems Medicine

Xiang ZeTong
Wu Xincheng
Chen Huishuang
Ding QiuXia
Kan LiJuan

Frontiers in Cardiovascular Medicine

159 views

Case Report

Accepted on 03 Apr 2026

Novel Compound Heterozygous Mutations in KLHL24-Induced Recessive Inherited Hypertrophic Cardiomyopathy: A Case Report

in Cardiovascular Genetics and Systems Medicine

Yingnan Liao
Wenjing Zhou
Xian Wang
Yingnan Liao

Frontiers in Cardiovascular Medicine

128 views

Case Report

Accepted on 31 Mar 2026

Two Cases of Recurrent Syncope Caused by KCNH2 Gene Mutation in Congenital Long QT Syndrome

in Cardiovascular Genetics and Systems Medicine

Aihua Xing
Lifang Liu
Wenjuan Pei
Xiaoyan Zhang

Frontiers in Cardiovascular Medicine

Case Report

Accepted on 30 Mar 2026

Newly-discovered Homozygous FKRP c.823C>T Mutation Causing Limb-Girdle Muscular Dystrophy-Related Dilated Cardiomyopathy

in Cardiovascular Genetics and Systems Medicine

Zhengyu Tao
CENYU LI
Yaohua Lin
Chen Wu
Zi Wang
Zhixuan Zhang
Xiaoning Wang
Meng Jiang
Jun Pu

Frontiers in Cardiovascular Medicine

Original Research

Accepted on 30 Mar 2026

Polygenic Risk Modulates Myocardial Repolarization and T-Wave Geometry in Congenital Long-QT Syndrome Type 1: Evidence from Digital ECG Phenotyping

in Cardiovascular Genetics and Systems Medicine

Elinor Tzvi-Minker
Sven Dittmann
Christian Krijger Juárez
Andreas Keck
Eric Schulze-Bahr

Frontiers in Cardiovascular Medicine

Original Research

Published on 27 Mar 2026

Machine learning-derived identification of an obesity and lipid metabolism-related genes signature for the diagnosis and molecular typing of acute myocardial infarction

in Cardiovascular Genetics and Systems Medicine

Jianhua Li
Zixin Xue
Min Zhang
Feng Lu
Shaoping Ji

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1694872

196 views

Original Research

Accepted on 26 Mar 2026

Bidirectional Mendelian randomization analysis of hypertension, coronary artery disease, and gastric cancer with supplementary clinical data

in Cardiovascular Genetics and Systems Medicine

Yun-Meng Tian
Qian Ma
Ya-Fei Kong
Ai-Li Li
Li-Na Song

Frontiers in Cardiovascular Medicine

Original Research

Published on 26 Mar 2026

A TNNT2 variant in a sporadic case of dilated cardiomyopathy: a case report and review

in Cardiovascular Genetics and Systems Medicine

Xinglin Chen
Zhengjie Huang
Qi Zheng
Lingfeng Zha
Tingting Tang
Xiang Cheng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1757484

147 views

Review

Accepted on 24 Mar 2026

Role of Exercise in Cardiovascular Health: A Narrative Review from Prevention to Therapeutic Utilizations

in Cardiovascular Genetics and Systems Medicine

Yong Wang
Xingbin Du
Qixing Wang

Frontiers in Cardiovascular Medicine

Case Report

Published on 16 Mar 2026

Case Report: Contrasting phenotypes of arrhythmogenic cardiomyopathy: classic desmosomal ARVC and a RIT1-related phenocopy

in Cardiovascular Genetics and Systems Medicine

Bo Eun Park
Dong Heon Yang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1786847

172 views

Original Research

Published on 13 Mar 2026

Pathway-specific polygenic risk scores for blood pressure traits in a West African cohort

in Cardiovascular Genetics and Systems Medicine

Gregory Bormes
Vanessa Robbin
Tinashe Chikowore
Yuji Zhang
Ananyo Choudhury
Scott Hazelhurst
Neil A. Hanchard
Sally N. Adebamowo
Adebowale A. Adeyemo
Bamidele Tayo

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1707809

266 views

Original Research

Published on 12 Mar 2026

Comprehensive lnc-RNAs expression profiles in uremic cardiomyopathy before and after renal transplantation

in Cardiovascular Genetics and Systems Medicine

Xiaoxia Song
Sijia Zhao
Pin Sun
Xiaofei Chen
Hongyang Wang
Yuanyuan Meng
Mingming Lin
Xiaofan Wang
Tao Yu
Zhirong Jiang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1718529

185 views

Systematic Review

Accepted on 11 Mar 2026

Are Clinical Trajectories in Obstructive Hypertrophic Cardiomyopathy Mutation-Specific? A Systematic Review and Meta-Analysis of MYH7 versus MYBPC3

in Cardiovascular Genetics and Systems Medicine

Yunqing Li
Jin Yu

Frontiers in Cardiovascular Medicine

Case Report

Accepted on 10 Mar 2026

Recurrent Myocarditis in a Young Female with a Desmoplakin Gene Variant: A Case Report and Literature Review

in Cardiovascular Genetics and Systems Medicine

Chenxi Liu
Wen Wen
Mingyue Qu
Jin Zhitao
Jiaojiao Xu
Xiaojiong Lu
Zheng Zhang

Frontiers in Cardiovascular Medicine

Case Report

Published on 10 Mar 2026

Case Report: De novo USP9X missense mutation in a male fetus with pulmonary atresia and ventricular septal defect: expanding the genotype-phenotype spectrum of USP9X-related disorders

in Cardiovascular Genetics and Systems Medicine

Tingting Man
Hairui Sun
Xiaoyan Hao
Xiaowei Liu
Yihua He

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1726544

208 views

Original Research

Published on 05 Mar 2026

Senescence-related epicardial adipocyte genes lead to immune infiltration and myocardial infarction progression

in Cardiovascular Genetics and Systems Medicine

Zhihuan Dong
Limin Wang
Yuheng Lang
Ruiying Zhang
Yuchao Wang
Chengxiu Zhao
Qingliang Chen
Yue Zheng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1759091

291 views

Review

Published on 05 Mar 2026

Autophagy, telomerase, and endothelial dysfunction in COVID-19–induced cardiac injury: an evidence-graded genetic and epigenetic synthesis

in Cardiovascular Genetics and Systems Medicine

HariOm Singh
Gaurav Tripathi
Abdul Arif Khan
Amita Verma
Anchal Singh

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1769828

586 views

Original Research

Published on 19 Feb 2026

Characterization of the R893C NaV1.5 mutation in Brugada syndrome

in Cardiovascular Genetics and Systems Medicine

Szabolcs Gaal
Beata Meszaros
Julianna Volko
Noemi Bilakovics
Muhammad Umair Naseem
Zoltán Pethő
Gabor Sandorfi
Gabor Menko
Orsolya Voros
Istvan Balogh

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1726536

490 views

Review

Published on 17 Feb 2026

Broadening horizons: new links between cilia and heart development and disease

in Cardiovascular Genetics and Systems Medicine

Wenqi Ma
Zhuofeng Zhang
Yun Ma
Chengxu Ma

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1699088

458 views

Case Report

Published on 30 Jan 2026

POEMS syndrome with cardiovascular lesions as the initial manifestation: a case report and literature review

in Cardiovascular Genetics and Systems Medicine

Xiuwei Tan
Gaowei Fan
Jiateng Yao
Changwei Lu
Zhaojie Qin

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1716667

623 views

531 articles

articles

Case Report: A young man with mitochondrial disease: intellectual impairment and myocardial hypertrophy

Transcriptional regulation in cardiovascular aging

Case report: Typical triad of Danon disease caused by a LAMP2 splice-donor variant with multi-level functional validation

Case Report: Severe protein S deficiency unmasks a cryptic PROC mutation with normal activity, triggering life-threatening pulmonary thromboembolism

A Novel GDF1 Frameshift Mutation in a Young Adult with Right Coronary Artery Hypoplasia and Myocardial Bridging: A Case Report

Novel Compound Heterozygous Mutations in KLHL24-Induced Recessive Inherited Hypertrophic Cardiomyopathy: A Case Report

Two Cases of Recurrent Syncope Caused by KCNH2 Gene Mutation in Congenital Long QT Syndrome

Newly-discovered Homozygous FKRP c.823C>T Mutation Causing Limb-Girdle Muscular Dystrophy-Related Dilated Cardiomyopathy

Polygenic Risk Modulates Myocardial Repolarization and T-Wave Geometry in Congenital Long-QT Syndrome Type 1: Evidence from Digital ECG Phenotyping

Machine learning-derived identification of an obesity and lipid metabolism-related genes signature for the diagnosis and molecular typing of acute myocardial infarction

Bidirectional Mendelian randomization analysis of hypertension, coronary artery disease, and gastric cancer with supplementary clinical data

A TNNT2 variant in a sporadic case of dilated cardiomyopathy: a case report and review

Role of Exercise in Cardiovascular Health: A Narrative Review from Prevention to Therapeutic Utilizations

Case Report: Contrasting phenotypes of arrhythmogenic cardiomyopathy: classic desmosomal ARVC and a RIT1-related phenocopy

Pathway-specific polygenic risk scores for blood pressure traits in a West African cohort

Comprehensive lnc-RNAs expression profiles in uremic cardiomyopathy before and after renal transplantation

Are Clinical Trajectories in Obstructive Hypertrophic Cardiomyopathy Mutation-Specific? A Systematic Review and Meta-Analysis of MYH7 versus MYBPC3

Recurrent Myocarditis in a Young Female with a Desmoplakin Gene Variant: A Case Report and Literature Review

Case Report: De novo USP9X missense mutation in a male fetus with pulmonary atresia and ventricular septal defect: expanding the genotype-phenotype spectrum of USP9X-related disorders

Senescence-related epicardial adipocyte genes lead to immune infiltration and myocardial infarction progression

Autophagy, telomerase, and endothelial dysfunction in COVID-19–induced cardiac injury: an evidence-graded genetic and epigenetic synthesis

Characterization of the R893C NaV1.5 mutation in Brugada syndrome

Broadening horizons: new links between cilia and heart development and disease

POEMS syndrome with cardiovascular lesions as the initial manifestation: a case report and literature review