Frontiers in Cardiovascular Medicine | Cardiovascular Genetics and Systems Medicine

Original Research

Published on 19 Feb 2026

Characterization of the R893C NaV1.5 mutation in Brugada syndrome

in Cardiovascular Genetics and Systems Medicine

Szabolcs Gaal
Beata Meszaros
Julianna Volko
Noemi Bilakovics
Muhammad Umair Naseem
Zoltán Pethő
Gabor Sandorfi
Gabor Menko
Orsolya Voros
Istvan Balogh

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1726536

165 views

Original Research

Accepted on 18 Feb 2026

Pathway-Specific Polygenic Risk Scores for Blood Pressure Traits in a West African Cohort

in Cardiovascular Genetics and Systems Medicine

Gregory Bormes
Vanessa Robbin
Tinashe Chikwore
Yuji Zhang
Ananyo Choudhury
Scott Hazelhurst
Neil Hanchard
Sally N Adebamowo
Adebowale Adeyemo
Bamidele Tayo

Frontiers in Cardiovascular Medicine

Review

Published on 17 Feb 2026

Broadening horizons: new links between cilia and heart development and disease

in Cardiovascular Genetics and Systems Medicine

Wenqi Ma
Zhuofeng Zhang
Yun Ma
Chengxu Ma

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1699088

173 views

Original Research

Accepted on 16 Feb 2026

Senescence-related epicardial adipocyte genes lead to immune infiltration and myocardial infarction progression

in Cardiovascular Genetics and Systems Medicine

Zhihuan Dong
Limin Wang
Yuheng Lang
Ruiying Zhang
Yuchao Wang
Chengxiu Zhao
Qingliang Chen
Yue Zheng

Frontiers in Cardiovascular Medicine

Case Report

Accepted on 16 Feb 2026

Case report: De Novo USP9X Missense Mutation in a Male Fetus with Pulmonary Atresia and Ventricular Septal Defect: Expanding the Genotype-Phenotype Spectrum of USP9X-Related Disorders

in Cardiovascular Genetics and Systems Medicine

Tingting Man
Hairui Sun
Xiaoyan Hao
Xiaowei Liu
YIhua He

Frontiers in Cardiovascular Medicine

Review

Accepted on 09 Feb 2026

Autophagy, Telomerase, and Endothelial Dysfunction in COVID-19–Induced Cardiac Injury: An Evidence-Graded Genetic and Epigenetic Synthesis

in Cardiovascular Genetics and Systems Medicine

Hari Om Singh
Gaurav Tripathi
Abdul Arif Khan
Amita Verma
Anchal Anchal

Frontiers in Cardiovascular Medicine

111 views

Case Report

Published on 30 Jan 2026

POEMS syndrome with cardiovascular lesions as the initial manifestation: a case report and literature review

in Cardiovascular Genetics and Systems Medicine

Xiuwei Tan
Gaowei Fan
Jiateng Yao
Changwei Lu
Zhaojie Qin

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1716667

436 views

Original Research

Published on 23 Jan 2026

Clinically validated immune-related gene markers and molecular subtypes in acute myocardial infarction revealed by peripheral blood transcriptomics

in Cardiovascular Genetics and Systems Medicine

Qingquan Zhang
Mingyan Yu
Peiran Xu
Louyuan Xu
Zhe Wang
Liang Chen
Koulong Zheng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2026.1643959

460 views

Review

Published on 19 Jan 2026

Next generation sequencing in dilated cardiomyopathy: utility and challenges in the African context

in Cardiovascular Genetics and Systems Medicine

Minenhle Mayisela
Dineo Mpanya
Umar G. Adamu
Phelelani T. Mpangase
Zané Lombard
Joel Amoni
Nonkanyiso Mboweni
Nqoba Tsabedze

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1717936

736 views

Original Research

Published on 14 Jan 2026

Bioinformatics analyses reveal the autophagy-related feature biomarkers in dilated cardiomyopathy with heart failure

in Cardiovascular Genetics and Systems Medicine

Jiayu Ren
Zhihan Li
Yue Wang
Ying Wang
Jing Li

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1692768

664 views

Original Research

Published on 12 Jan 2026

Construction of a competitive endogenous RNA network and identification of potential regulatory axes in hypertrophic cardiomyopathy

in Cardiovascular Genetics and Systems Medicine

Rui Gao
Meilin Liu
Haoyi Yang
Lingfeng Zha
Ni Xia

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1552060

723 views

Original Research

Published on 12 Jan 2026

Hsa_circ_0005623 is an indicator for pulmonary artery hypertension associated with congenital heart disease

in Cardiovascular Genetics and Systems Medicine

Yuanhao Zhang
Yan Han
Zirui Sun
Weizhen Xing
Hao Tang
Chuanyu Gao
Yu Han

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1561069

939 views

Case Report

Published on 05 Jan 2026

A case report of a Chinese patient with obstructive hypertrophic cardiomyopathy harboring rare variants in both the MYBPC3 and DSP genes

in Cardiovascular Genetics and Systems Medicine

Xiao-Yuan Wu
Ning Ren
Jie Geng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1630263

720 views

Original Research

Published on 02 Jan 2026

A pathogenic titin missense mutation in hiPSC-derived cardiomyocytes predisposes to ventricular fibrillation in acute ST-segment elevation myocardial infarction

in Cardiovascular Genetics and Systems Medicine

Ying-Ying Ji
Yang Wu
Ji Sun
Xiao-Xiong Lin
Xu-Miao Chen
Cheng-Cheng Ji
Li-Juan Liu
Yun-Jiu Cheng
Su-Hua Wu

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1691585

1,284 views

Case Report

Published on 18 Dec 2025

Case Report: Lethal neonatal hypertrophic cardiomyopathy from compound heterozygous MYBPC3 variants

in Cardiovascular Genetics and Systems Medicine

Jianying Wang
Lingye Hong
Yao Li
Zhengrong Mao
Yuefeng Zhu
Ming Qi
Ren Zhou
Xutao Hong

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1726463

1,010 views

Original Research

Published on 15 Dec 2025

Identification of arachidonic acid metabolism-related diagnostic markers in heart failure based on bioinformatics analysis and machine learning

in Cardiovascular Genetics and Systems Medicine

Saiqing Chen
Chunxia Zhang
Yueting Yu

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1625064

1,083 views

Original Research

Published on 20 Nov 2025

Combining WGCNA and machine learning to identify mechanisms and biomarkers of hyperthyroidism and atrial fibrillation

in Cardiovascular Genetics and Systems Medicine

Linyuan Wang
Kun Yang
Ruilong Kang
Pengbo Liu
Yongzhi Deng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1694255

1,166 views

Case Report

Published on 20 Nov 2025

Severe cardiac valvular calcification in two Chinese brothers with mandibuloacral dysplasia type A: a case report

in Cardiovascular Genetics and Systems Medicine

Yi Guo
Xinyi Zhang
Yanfei Meng
Qiuzhe Guo
Xiaoqi Wang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1657197

1,318 views

Original Research

Published on 19 Nov 2025

Single cell RNA sequencing reveals a dysbalance of proinflammatory vs. immunosuppressive dendritic cells in mouse and human aortic aneurysms

in Cardiovascular Genetics and Systems Medicine

Yi Ran
Jingpu Zhu
Ting Sun
Yixin Zhang
Chuankai Zhang
Yutao Li
Zhipeng Li
Shu Wang
Liping Li
Junjie Zheng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1713030

1,453 views

Case Report

Published on 11 Nov 2025

Case Report: A novel TTN gene variant and a concurrent rare COL4A4 gene variant in a Chinese patient with dilated cardiomyopathy

in Cardiovascular Genetics and Systems Medicine

Shan Han
Ying-Yi Zhang
Jie Geng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1668842

1,103 views

Original Research

Published on 03 Nov 2025

The analysis reveals novel hub genes and pathways associated with Tetralogy of Fallot

in Cardiovascular Genetics and Systems Medicine

Heling Wen
Zheng Huang
Yujie Mao
Wenjie Tian
Lei Peng
Yu Chen

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1604939

1,170 views

Original Research

Published on 15 Oct 2025

Comprehensive analysis of m6A methylated modification of fibrotic atria in rats induced by chronic intermittent hypoxia

in Cardiovascular Genetics and Systems Medicine

Tao Geng
Shiyu Qi
Xuan Cao
Jiao Li
Xiaodong Xia
Tianshu Gu
Hualing Wang
Pengyu Sun
Siyu Guan
Wenfeng Shangguan

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1670859

1,495 views

Case Report

Published on 08 Oct 2025

A novel LAMP2 initiation codon mutation causes Danon Disease: a case report

in Cardiovascular Genetics and Systems Medicine

Qingchuan Li
Zhihong Sun
Zeping Qiu
Yanjia Chen
Wei Jin

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1699732

1,873 views

Case Report

Published on 07 Oct 2025

Case Report: Novel combinatorial factors in the WNT pathway in a pediatric case of valvular aortic stenosis from Lebanon: a brief report

in Cardiovascular Genetics and Systems Medicine

Wiam Ataya
Fathima Mohammed
Mariam Arabi
Fadi Bitar
Georges Nemer

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1614666

1,386 views

514 articles

articles

Characterization of the R893C NaV1.5 mutation in Brugada syndrome

Pathway-Specific Polygenic Risk Scores for Blood Pressure Traits in a West African Cohort

Broadening horizons: new links between cilia and heart development and disease

Senescence-related epicardial adipocyte genes lead to immune infiltration and myocardial infarction progression

Case report: De Novo USP9X Missense Mutation in a Male Fetus with Pulmonary Atresia and Ventricular Septal Defect: Expanding the Genotype-Phenotype Spectrum of USP9X-Related Disorders

Autophagy, Telomerase, and Endothelial Dysfunction in COVID-19–Induced Cardiac Injury: An Evidence-Graded Genetic and Epigenetic Synthesis

POEMS syndrome with cardiovascular lesions as the initial manifestation: a case report and literature review

Clinically validated immune-related gene markers and molecular subtypes in acute myocardial infarction revealed by peripheral blood transcriptomics

Next generation sequencing in dilated cardiomyopathy: utility and challenges in the African context

Bioinformatics analyses reveal the autophagy-related feature biomarkers in dilated cardiomyopathy with heart failure

Construction of a competitive endogenous RNA network and identification of potential regulatory axes in hypertrophic cardiomyopathy

Hsa_circ_0005623 is an indicator for pulmonary artery hypertension associated with congenital heart disease

A case report of a Chinese patient with obstructive hypertrophic cardiomyopathy harboring rare variants in both the MYBPC3 and DSP genes

A pathogenic titin missense mutation in hiPSC-derived cardiomyocytes predisposes to ventricular fibrillation in acute ST-segment elevation myocardial infarction

Case Report: Lethal neonatal hypertrophic cardiomyopathy from compound heterozygous MYBPC3 variants

Identification of arachidonic acid metabolism-related diagnostic markers in heart failure based on bioinformatics analysis and machine learning

Combining WGCNA and machine learning to identify mechanisms and biomarkers of hyperthyroidism and atrial fibrillation

Severe cardiac valvular calcification in two Chinese brothers with mandibuloacral dysplasia type A: a case report

Single cell RNA sequencing reveals a dysbalance of proinflammatory vs. immunosuppressive dendritic cells in mouse and human aortic aneurysms

Case Report: A novel TTN gene variant and a concurrent rare COL4A4 gene variant in a Chinese patient with dilated cardiomyopathy

The analysis reveals novel hub genes and pathways associated with Tetralogy of Fallot

Comprehensive analysis of m6A methylated modification of fibrotic atria in rats induced by chronic intermittent hypoxia

A novel LAMP2 initiation codon mutation causes Danon Disease: a case report

Case Report: Novel combinatorial factors in the WNT pathway in a pediatric case of valvular aortic stenosis from Lebanon: a brief report