Frontiers in Cardiovascular Medicine | Cardiovascular Genetics and Systems Medicine

Case Report

Published on 11 Nov 2025

Case Report: A novel TTN gene variant and a concurrent rare COL4A4 gene variant in a Chinese patient with dilated cardiomyopathy

in Cardiovascular Genetics and Systems Medicine

Shan Han
Ying-Yi Zhang
Jie Geng

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1668842

150 views

Original Research

Accepted on 10 Nov 2025

Combining WGCNA and machine learning to identify mechanisms and biomarkers of hyperthyroidism and atrial fibrillation

in Cardiovascular Genetics and Systems Medicine

Linyuan Wang
Kun Yang
Ruilong Kang
Pengbo Liu
Yongzhi Deng

Frontiers in Cardiovascular Medicine

Original Research

Accepted on 04 Nov 2025

Single cell RNA Sequencing Reveals a Dysbalance of Proinflammatory versus Immunosuppressive Dendritic Cells in Mouse and Human Aortic Aneurysms

in Cardiovascular Genetics and Systems Medicine

Yi Ran
Jingpu Zhu
Ting Sun
Yixin Zhang
Chuankai Zhang
Yutao Li
Zhipeng Li
Shu Wang
Liping Li
Junjie Zheng

Frontiers in Cardiovascular Medicine

143 views

Original Research

Published on 03 Nov 2025

The analysis reveals novel hub genes and pathways associated with Tetralogy of Fallot

in Cardiovascular Genetics and Systems Medicine

Heling Wen
Zheng Huang
Yujie Mao
Wenjie Tian
Lei Peng
Yu Chen

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1604939

319 views

Case Report

Accepted on 28 Oct 2025

Severe cardiac valvular calcification in two Chinese brothers with Mandibuloacral dysplasia type A: A Case Report

in Cardiovascular Genetics and Systems Medicine

Yi Guo
Xinyi Zhang
Yanfei Meng
Qiuzhe Guo
Xiaoqi Wang

Frontiers in Cardiovascular Medicine

267 views

Original Research

Published on 15 Oct 2025

Comprehensive analysis of m6A methylated modification of fibrotic atria in rats induced by chronic intermittent hypoxia

in Cardiovascular Genetics and Systems Medicine

Tao Geng
Shiyu Qi
Xuan Cao
Jiao Li
Xiaodong Xia
Tianshu Gu
Hualing Wang
Pengyu Sun
Siyu Guan
Wenfeng Shangguan

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1670859

880 views

Case Report

Published on 08 Oct 2025

A novel LAMP2 initiation codon mutation causes Danon Disease: a case report

in Cardiovascular Genetics and Systems Medicine

Qingchuan Li
Zhihong Sun
Zeping Qiu
Yanjia Chen
Wei Jin

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1699732

1,185 views

Case Report

Published on 07 Oct 2025

Case Report: Novel combinatorial factors in the WNT pathway in a pediatric case of valvular aortic stenosis from Lebanon: a brief report

in Cardiovascular Genetics and Systems Medicine

Wiam Ataya
Fathima Mohammed
Mariam Arabi
Fadi Bitar
Georges Nemer

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1614666

940 views

Original Research

Published on 01 Oct 2025

C5L2 gene polymorphisms and their functional interaction with metabolic-inflammatory networks in T2DM-associated CHD: insights from an integrative genetic and clinical analysis in a Chinese population

in Cardiovascular Genetics and Systems Medicine

Mengjia Liu
Fen Liu
Dilihumaer Abulaiti
Juan Yang
Yating Wang
Meng Ye
Taotao Jia
Ying Gao

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1629294

9,288 views

Original Research

Published on 24 Sep 2025

Genetic relationship between Sjögren's syndrome and abdominal aortic aneurysm: insights from a European population's genome-wide association analysis

in Cardiovascular Genetics and Systems Medicine

Yunanji Zhou
Hao Xiong
Qinghua Luo
Zhaohui Ding
Jun He
Lihua Wang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1554991

1,518 views

Original Research

Published on 17 Sep 2025

Integrative transcriptomic analysis reveals diagnostic biomarkers for comorbidity of coronary artery disease and obstructive sleep apnea

in Cardiovascular Genetics and Systems Medicine

Qingquan Liu
Xiaoyu Chen
Shuhan Chen
Hongzhi Gao
Meiting He
Yingting Shi
Mingzhu Zhao
Liying Yu
Huili Lin

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1658016

1,741 views

Original Research

Published on 11 Sep 2025

Comprehensive analysis of aging-related genes and immune infiltration landscape in ischemic cardiomyopathy

in Cardiovascular Genetics and Systems Medicine

Zhichao Wu
Liang Du
Xunfu Zhang
Chengyu Jin
Jinshan Ma

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1653314

1,484 views

Correction

Published on 29 Aug 2025

Correction: Comprehensive analysis of the transcriptome-wide m6A methylome of heart via MeRIP after birth: day 0 vs. day 7

in Cardiovascular Genetics and Systems Medicine

Chuanxi Yang
Kun Zhao
Jing Zhang
Xiaoguang Wu
Wei Sun
Xiangqing Kong
Jing Shi

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1662054

919 views

Review

Published on 01 Aug 2025

Cardioepigenetics in action: aerobic exercise-induced modulation of miRNAs, lncRNAs, and chromatin remodeling in cardiovascular disease

in Cardiovascular Genetics and Systems Medicine

Shoudu Yuan
Qi Ye
Ran Qin

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1579352

2,347 views

Original Research

Published on 28 Jul 2025

Identification of candidate cardiomyopathy modifier genes through genome sequencing and RNA profiling

in Cardiovascular Genetics and Systems Medicine

Malene E. Lindholm
Sarah Abramowitz
Daryl M. Waggott
Megan E. Grove
Frederick E. Dewey
Cuiping Pan
Aleksandra Pavlovic
Ching Shang
Yong Huang
Leore Bensabath

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1546493

2,466 views

Original Research

Published on 10 Jul 2025

A case of arrhythmic cardiomyopathy caused by rare multiple gene mutations

in Cardiovascular Genetics and Systems Medicine

Kaiqin Liang
Hong Wang
Minfang Wu
Meng Cui
Kaiyou Liu
Mintao Gan
Wengong Cheng
Aiqiong Huang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1598085

1,502 views