Frontiers in Cardiovascular Medicine | Cardiovascular Genetics and Systems Medicine

Original Research

Accepted on 20 Oct 2025

The Analysis Reveals Novel Hub Genes and Pathways Associated with Tetralogy of Fallot

in Cardiovascular Genetics and Systems Medicine

Heling Wen
Zheng Huang
Yujie Mao
Wenjie Tian
Lei Peng
Yu Chen

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1604939

Original Research

Published on 15 Oct 2025

Comprehensive analysis of m6A methylated modification of fibrotic atria in rats induced by chronic intermittent hypoxia

in Cardiovascular Genetics and Systems Medicine

Tao Geng
Shiyu Qi
Xuan Cao
Jiao Li
Xiaodong Xia
Tianshu Gu
Hualing Wang
Pengyu Sun
Siyu Guan
Wenfeng Shangguan

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1670859

525 views

Case Report

Published on 08 Oct 2025

A novel LAMP2 initiation codon mutation causes Danon Disease: a case report

in Cardiovascular Genetics and Systems Medicine

Qingchuan Li
Zhihong Sun
Zeping Qiu
Yanjia Chen
Wei Jin

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1699732

816 views

Case Report

Published on 07 Oct 2025

Case Report: Novel combinatorial factors in the WNT pathway in a pediatric case of valvular aortic stenosis from Lebanon: a brief report

in Cardiovascular Genetics and Systems Medicine

Wiam Ataya
Fathima Mohammed
Mariam Arabi
Fadi Bitar
Georges Nemer

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1614666

732 views

Original Research

Published on 01 Oct 2025

C5L2 gene polymorphisms and their functional interaction with metabolic-inflammatory networks in T2DM-associated CHD: insights from an integrative genetic and clinical analysis in a Chinese population

in Cardiovascular Genetics and Systems Medicine

Mengjia Liu
Fen Liu
Dilihumaer Abulaiti
Juan Yang
Yating Wang
Meng Ye
Taotao Jia
Ying Gao

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1629294

8,946 views

Original Research

Published on 24 Sep 2025

Genetic relationship between Sjögren's syndrome and abdominal aortic aneurysm: insights from a European population's genome-wide association analysis

in Cardiovascular Genetics and Systems Medicine

Yunanji Zhou
Hao Xiong
Qinghua Luo
Zhaohui Ding
Jun He
Lihua Wang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1554991

1,343 views

Original Research

Published on 17 Sep 2025

Integrative transcriptomic analysis reveals diagnostic biomarkers for comorbidity of coronary artery disease and obstructive sleep apnea

in Cardiovascular Genetics and Systems Medicine

Qingquan Liu
Xiaoyu Chen
Shuhan Chen
Hongzhi Gao
Meiting He
Yingting Shi
Mingzhu Zhao
Liying Yu
Huili Lin

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1658016

1,542 views

Original Research

Published on 11 Sep 2025

Comprehensive analysis of aging-related genes and immune infiltration landscape in ischemic cardiomyopathy

in Cardiovascular Genetics and Systems Medicine

Zhichao Wu
Liang Du
Xunfu Zhang
Chengyu Jin
Jinshan Ma

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1653314

1,331 views

Correction

Published on 29 Aug 2025

Correction: Comprehensive analysis of the transcriptome-wide m6A methylome of heart via MeRIP after birth: day 0 vs. day 7

in Cardiovascular Genetics and Systems Medicine

Chuanxi Yang
Kun Zhao
Jing Zhang
Xiaoguang Wu
Wei Sun
Xiangqing Kong
Jing Shi

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1662054

855 views

Review

Published on 01 Aug 2025

Cardioepigenetics in action: aerobic exercise-induced modulation of miRNAs, lncRNAs, and chromatin remodeling in cardiovascular disease

in Cardiovascular Genetics and Systems Medicine

Shoudu Yuan
Qi Ye
Ran Qin

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1579352

2,179 views

Original Research

Published on 28 Jul 2025

Identification of candidate cardiomyopathy modifier genes through genome sequencing and RNA profiling

in Cardiovascular Genetics and Systems Medicine

Malene E. Lindholm
Sarah Abramowitz
Daryl M. Waggott
Megan E. Grove
Frederick E. Dewey
Cuiping Pan
Aleksandra Pavlovic
Ching Shang
Yong Huang
Leore Bensabath

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1546493

2,239 views

Original Research

Published on 10 Jul 2025

A case of arrhythmic cardiomyopathy caused by rare multiple gene mutations

in Cardiovascular Genetics and Systems Medicine

Kaiqin Liang
Hong Wang
Minfang Wu
Meng Cui
Kaiyou Liu
Mintao Gan
Wengong Cheng
Aiqiong Huang

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1598085

1,419 views

Original Research

Published on 02 Jul 2025

Disulfidptosis-related gene in acute myocardial infarction and its diagnostic value and functions based on bioinformatics analysis and machine learning

in Cardiovascular Genetics and Systems Medicine

Liwen Chen
Jinru Wei
Guoxiong Deng
Guien Xu

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1513342

2,004 views

Review

Published on 30 Jun 2025

Emerging mechanisms and implications of m6A in CVDs: potential applications of natural products

in Cardiovascular Genetics and Systems Medicine

Hui Wang
Yun Zhang
Xiao Jiang
Guichun Liu
Shujian Xu
Jinbiao He
Xudong He
Ting Xiao
Lijuan Wang
LiJing Xiao

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1559064

1,654 views
1 citation

Case Report

Published on 24 Jun 2025

Case Report: A heterozygous loss-of-function variant of the ERG gene in a family with vascular pathologies

in Cardiovascular Genetics and Systems Medicine

Philipp Erhart
Nicola Dikow
Eva M. C. Schwaibold
Susanne Dihlmann
Caspar Grond-Ginsbach
Daniel Körfer
Christian P. Schaaf
Sabrina Oeser
Katrin Hinderhofer
Dittmar Böckler

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1550523

1,319 views

Case Report

Published on 23 Jun 2025

The genomic bases of atrial fibrillation in an Ecuadorian patient: a case report

in Cardiovascular Genetics and Systems Medicine

Rafael Tamayo-Trujillo
Patricia Guevara-Ramirez
Leonel Meza-Chico
Santiago Cadena-Ullauri
Viviana A. Ruiz-Pozo
Elius Paz-Cruz
José Luis Laso-Bayas
Rita Ibarra-Castillo
Ana Karina Zambrano

Frontiers in Cardiovascular Medicine

doi 10.3389/fcvm.2025.1552417

1,499 views