Frontiers in Cell and Developmental Biology | Molecular and Cellular Pathology

Original Research

Published on 16 Dec 2025

Microglia response and function in a chronic model of photoreceptor damage

in Molecular and Cellular Pathology

Deepa Raghavan
Olivia Jeakle
Yasmeen Berry
Majd Victor
Ryan Thummel

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1699271

142 views

Original Research

Published on 16 Dec 2025

Image-text guided fundus vessel segmentation via attention mechanism and gated residual learning

in Molecular and Cellular Pathology

Jianguo Xu
Qingyou Liu
Jianxin Shen
Rong Tan
Sukun Tian
Wei Chi
Weihua Yang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1710343

117 views

Original Research

Accepted on 15 Dec 2025

Macrophage-myofibroblast transition as a novel therapeutic target in shoulder stiffness: multi-omics study and experimental validation

in Molecular and Cellular Pathology

Beijie Qi
Weihan Yu
Hanyi Wang
Yuqi Li
Shuang Deng
Chengqing Yi

Frontiers in Cell and Developmental Biology

Original Research

Accepted on 15 Dec 2025

Integration of peripheral blood-based systemic inflammatory indices and retinal imaging using interpretable machine learning for predicting anti-VEGF treatment response in macular edema secondary to retinal vein occlusion

in Molecular and Cellular Pathology

Jiajun Li
Yao Lu
Qianzi Jin
Siqi Wu
Xiangzhong Xu
Qin Jiang
Keran Li

Frontiers in Cell and Developmental Biology

Review

Accepted on 12 Dec 2025

Progress on the Mechanism of Polycystin-1 in Bone Remodeling

in Molecular and Cellular Pathology

JinShi Guo
Hu Guangxuan
Xiaoying Li
Tao Li
Xuejie Yi
Bo Chang

Frontiers in Cell and Developmental Biology

Original Research

Accepted on 12 Dec 2025

Fibroblast growth factor 9 activates fibroblast activation and drives the progress of shoulder stiffness

in Molecular and Cellular Pathology

Jian Xu
Weihan Yu
Yunkang Kang
Dongqiang Yang
Yanlong Liu
Wenzhi Bi
Haiyang Yu
Beijie Qi
Biao Guo

Frontiers in Cell and Developmental Biology

113 views

Original Research

Published on 12 Dec 2025

Effects of high-altitude environments on intervertebral disc degeneration and transcriptome profiling of the nucleus pulposus

in Molecular and Cellular Pathology

Jiawei Fu
Rong Tang
Tianfei Ran
Yue Zhou
Bo Huang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1709844

323 views

Original Research

Published on 11 Dec 2025

Knowledge-enhanced AI drives diagnosis of multiple retinal diseases in fundus fluorescein angiography

in Molecular and Cellular Pathology

Ming-Ming Duan
Hui Qi
Xiang Tu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1703606

284 views

Original Research

Published on 11 Dec 2025

Molecular insights into Atorvastatin’s role in delaying intervertebral disc degeneration

in Molecular and Cellular Pathology

Yupeng Li
Linghao Wang
Xingjie Wang
Kang Li
Qian Wang
Kai Gao
Cunxin Zhang
Chaoliang Lv

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1693951

249 views

Original Research

Published on 11 Dec 2025

Mathematical modeling reveals cell differentiation processes and progenitor kinetics necessary for proper nephrogenesis

in Molecular and Cellular Pathology

Matthew R. Hawkins
Stuart E. Jones
Hannah M. Wesselman
Cecilia Cesa
Joshua Moeller
Rebecca A. Wingert

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1695380

291 views

Review

Published on 10 Dec 2025

Sidedness matters: single-cell perspectives on left- and right-sided colorectal cancer

in Molecular and Cellular Pathology

Maria Yanova
Diana Maltseva
Alexander Tonevitsky

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1720996

423 views

Original Research

Accepted on 08 Dec 2025

Association of fibronectin 1 deregulation with tyrosine kinase inhibitor resistance in chronic myeloid leukemia

in Molecular and Cellular Pathology

Lina Tiedemann
Sivahari Gorantla
Philine Ahlf
Lucie Sophie Schmidt
Christiane Pott
Merit Litterst
Vicki Waetzig
Inga Nagel
Johanna Rümenapp
Nikolas von Bubnoff

Frontiers in Cell and Developmental Biology

137 views

Original Research

Accepted on 05 Dec 2025

Deciphering the Immunomodulatory Mechanisms of Periplaneta americana L. Extract CⅡ-3: Insight from Integrated Metabolomics and Network Pharmacology

in Molecular and Cellular Pathology

Yilin Wang
Yingxiang Wu
Xi Liu
Zhiyan Lu
Tianqian Li
Yang Jin
Yan Wang
Jiali Zhu

Frontiers in Cell and Developmental Biology

173 views

Mini Review

Accepted on 04 Dec 2025

A primer on tRNAs, tRNA-m1A58 modification, and tRNA derivatives in T-cell activation

in Molecular and Cellular Pathology

Chuanxiang Zhao
Juxiang Shen

Frontiers in Cell and Developmental Biology

103 views

Original Research

Published on 04 Dec 2025

Quantitative analysis of the effect of ocular rotation on postoperative residual astigmatism in small incision lenticule extraction for myopia correction

in Molecular and Cellular Pathology

Caiyu Liu
Xiaoying Xu
Hao Gu
Chi Wang
Lu Lu
Kaizhen Ye
Yan Zheng
Haiyan Wang
Wei Chen
Meiyan Li

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1695775

488 views

Original Research

Published on 04 Dec 2025

Loss of a primary cilia protein ARL13B promotes TGFβ-1 induced EMT of RPE in proliferative vitreoretinopathy via increasing Smad3 expression

in Molecular and Cellular Pathology

Wenjun Sui
Xinqi Ma
Yajun Gong
Kairui Qiu
Miner Yuan
Keli Mao
Xiaobing Qian
Jieting Zeng
Yujie Li
Bingsheng Lou

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1661658

455 views

Review

Accepted on 03 Dec 2025

The Varied Functions of the Giant Muscle Scaffold Protein Obscurin

in Molecular and Cellular Pathology

James Di Paola
Frieder Schöck

Frontiers in Cell and Developmental Biology

205 views

Original Research

Published on 03 Dec 2025

TNF-α exacerbates calcium influx via voltage-gated calcium channels in breast cancer cells: a nanoscale multimodal AFM study

in Molecular and Cellular Pathology

Zhongwei Wang
Qianhui Xu
Huaiwei Zhang
Rongrong Feng
Junmei Chen
Jinsong Wei
Haijian Zhong
Weidong Zhao

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1633976

405 views

Original Research

Published on 02 Dec 2025

Evaluating the competence of large language models in ophthalmology clinical practice: a multi-scenario quantitative study

in Molecular and Cellular Pathology

Mu-Yang Wei
Yu-Lin Li
Shu-Yan Liu
Guang-Yu Li

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1704762

511 views

Editorial

Published on 02 Dec 2025

Editorial: Cardiac fibroblasts: from development to disease

in Molecular and Cellular Pathology

Silvia C. Hernandez
Thomas Moore-Morris
Adrian Ruiz-Villalba

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1736508

374 views

Review

Accepted on 28 Nov 2025

The role of ADAR1 in human pathophysiology

in Molecular and Cellular Pathology

jiahao li
yushan xiao
Xiaofeng Li
Yan Dai

Frontiers in Cell and Developmental Biology

124 views

Review

Accepted on 27 Nov 2025

Proteolytic Enzyme Models as Tunable Preclinical Platforms for Investigating Intervertebral Disc Degeneration

in Molecular and Cellular Pathology

Jan Gewiess
Annamarie D’Intino
Alejandra Santos
Mauro Alini
Andrea Vernengo

Frontiers in Cell and Developmental Biology

183 views

Original Research

Published on 27 Nov 2025

Leukocyte mRNA sequencing reveals unfolded protein response activation in severe heat stroke in Japan

in Molecular and Cellular Pathology

Yusuke Nomura
Sayaka Oda
Hisatake Matsumoto
Yuki Togami
Junya Shimazaki
Daisuke Okuzaki
Hiroshi Ogura
Jun Oda

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1640477

603 views

Original Research

Published on 27 Nov 2025

Antiphotoaging effects of a group of antioxidant peptides through downregulating matrix metalloproteinases and inflammation factors

in Molecular and Cellular Pathology

Yichao Huang
Juxingsi Song
Zhengbang Wang
Shaoqian Zhu
Yanan Hu
Xinyue Gan
Sai Luo
Qian He
Liming Zhang
Qianqian Wang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1649391

471 views

2,450 articles

articles

Microglia response and function in a chronic model of photoreceptor damage

Image-text guided fundus vessel segmentation via attention mechanism and gated residual learning

Macrophage-myofibroblast transition as a novel therapeutic target in shoulder stiffness: multi-omics study and experimental validation

Integration of peripheral blood-based systemic inflammatory indices and retinal imaging using interpretable machine learning for predicting anti-VEGF treatment response in macular edema secondary to retinal vein occlusion

Progress on the Mechanism of Polycystin-1 in Bone Remodeling

Fibroblast growth factor 9 activates fibroblast activation and drives the progress of shoulder stiffness

Effects of high-altitude environments on intervertebral disc degeneration and transcriptome profiling of the nucleus pulposus

Knowledge-enhanced AI drives diagnosis of multiple retinal diseases in fundus fluorescein angiography

Molecular insights into Atorvastatin’s role in delaying intervertebral disc degeneration

Mathematical modeling reveals cell differentiation processes and progenitor kinetics necessary for proper nephrogenesis

Sidedness matters: single-cell perspectives on left- and right-sided colorectal cancer

Association of fibronectin 1 deregulation with tyrosine kinase inhibitor resistance in chronic myeloid leukemia

Deciphering the Immunomodulatory Mechanisms of Periplaneta americana L. Extract CⅡ-3: Insight from Integrated Metabolomics and Network Pharmacology

A primer on tRNAs, tRNA-m1A58 modification, and tRNA derivatives in T-cell activation

Quantitative analysis of the effect of ocular rotation on postoperative residual astigmatism in small incision lenticule extraction for myopia correction

Loss of a primary cilia protein ARL13B promotes TGFβ-1 induced EMT of RPE in proliferative vitreoretinopathy via increasing Smad3 expression

The Varied Functions of the Giant Muscle Scaffold Protein Obscurin

TNF-α exacerbates calcium influx via voltage-gated calcium channels in breast cancer cells: a nanoscale multimodal AFM study

Evaluating the competence of large language models in ophthalmology clinical practice: a multi-scenario quantitative study

Editorial: Cardiac fibroblasts: from development to disease

The role of ADAR1 in human pathophysiology

Proteolytic Enzyme Models as Tunable Preclinical Platforms for Investigating Intervertebral Disc Degeneration

Leukocyte mRNA sequencing reveals unfolded protein response activation in severe heat stroke in Japan

Antiphotoaging effects of a group of antioxidant peptides through downregulating matrix metalloproteinases and inflammation factors