Frontiers in Cell and Developmental Biology

Original Research

Published on 16 Oct 2025

Petunidin alleviates diabetic nephropathy injury via the inhibition of oxidative stress and ferroptosis through the Keap1/mitoNQO1 pathway

in Signaling

Yuli Qiu
Chao Chen
Xinyan Li
Yiling Chang
Xiaoqin Zou
Xiaopei Yan
Wenjun Mao
Gang Wu
Su Li
Yuqiong Chen

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1651382

578 views

Original Research

Accepted on 14 Oct 2025

Green-synthesized silver nanoparticles from edible plant extracts ameliorate cadmium chloride-induced hepatorenal and testicular toxicity in rats

in Signaling

Akram Abu-Okail
Nashwa Hamad
Ayman Mousa
Ahmed Abdellatif
Heba A. S. El-Nashar
Mohamed El-Shazly
Ramy K. A. Sayed
Waleed Abdulmonem
Mohamed Farghali
Heba F Kamaly

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1677434

180 views

Review

Accepted on 13 Oct 2025

Non-coding RNAs mediate mechanical load-regulating bone metabolic homeostasis

in Signaling

Ruiqi Huang
Bo Chang
Xuejie Yi

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1643255

Editorial

Published on 08 Oct 2025

Editorial: Targeting pulmonary endothelium in acute lung injury and acute respiratory distress syndrome

in Signaling

Lulong Bo
You Shang
Guochang Hu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1714104

418 views

Review

Published on 03 Oct 2025

From bench to bedside: therapeutic potential of natural antioxidants in diabetic neuropathy

in Signaling

Yanxian Zhang
Lili Yao
Yongmei Lyu
Zhuqi Tang
Xiaoyu Liu
Xuchu Duan

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1631678

562 views

Review

Accepted on 02 Oct 2025

Linking Signaling Dynamics and Cell Fate Decisions Through Single-Cell Imaging: Evidence and Challenges

in Signaling

Fulvio Bonsignore
Sara Pozzi
Erika Aloi
Davide Mazza
Samuel Zambrano

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1656051

306 views

Review

Accepted on 25 Sep 2025

UPRmt-Regulated Mitokines: Novel Strategies for Myocardial Injury Repair

in Signaling

Jia Liu
Wenda Zhang
Weinan Gao
Luyan Shen
Bin Liu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1652353

372 views

Review

Published on 25 Sep 2025

Osteocytes: master orchestrators of skeletal homeostasis, remodeling, and osteoporosis pathogenesis

in Signaling

Yan Wu
Donghao Gan
Zhikang Liu
Daodi Qiu
Guoqing Tan
Zhanwang Xu
Haipeng Xue

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1670716

2,202 views

Original Research

Published on 23 Sep 2025

IL-6 trans-signaling in cystic fibrosis bronchial cells potentiates TNF-α-driven ICAM-1 expression

in Signaling

John Lin
Lyvia Fourcade
Lucie Roussel
Matthew Marabella
Julie Bérubé
Dao Nguyen
Simon Rousseau

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1566482

950 views

Original Research

Published on 04 Sep 2025

Multi-transcriptomics analysis of ferroptosis related genes reveals CAFs exosomal COX4I2 as a novel therapeutic target in osteosarcoma

in Signaling

Xiaoying Niu
Xinxin Zhang
Zhongyi Li
Wen Tian

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1620648

2,210 views

Review

Published on 03 Sep 2025

Organoids in biliary research: insights into developmental signaling and applications in disease modeling

in Signaling

Boming Peng
Min Huang
Jianquan Zhang
Yang Xiang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1656019

2,444 views

Original Research

Published on 26 Aug 2025

Slit2 inhibits SRC-PI3K signaling pathway, regulates osteoclast differentiation of macrophages and reduces bone resorption

in Signaling

Qing Ge
Yaokun Zou
Huizhi Deng
Zhe Yang
Linhu Ge
Jieying Huang
Jianqiang Cai
Liping Wang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1632882

1,681 views

Review

Published on 26 Aug 2025

Critical signaling pathways in osteoclast differentiation and bone resorption: mechanisms and therapeutic implications for periprosthetic osteolysis

in Signaling

Liangzi Yin
Chenglin Sun
Junjie Zhang
Yan Li
Yansheng Wang
Lunhao Bai
Zeming Lei

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1639430

1,832 views

Review

Published on 22 Aug 2025

The multifaceted roles of E3 ubiquitin ligases in osteoarthritis

in Signaling

Zheng Jin
Zhenhua Zhu
Jun Chen
Xiaopeng Jing
Jie Tan
Ji Zeng

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1665313

991 views

Original Research

Published on 20 Aug 2025

Endogenous ligands of bovine FFAR2/GPR43 display distinct pharmacological properties

in Signaling

Tainara Cristina Michelotti
Valérie Lamothe
Frédéric Jean-Alphonse
Eric Reiter
Muriel Bonnet
Guillaume Durand

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1645031

1,287 views

Review

Published on 15 Aug 2025

The role of gut microbiota dysbiosis in drug-induced brain injury: mechanisms and therapeutic implications

in Signaling

Jinghui Zhai
Yue Zhang
Shuyue Ma
Yingli Zhang
Miao Jin
Huiyu Yan
Sixi Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1604539

1,385 views