Frontiers in Cell and Developmental Biology

Original Research

Published on 23 Sep 2025

IL-6 trans-signaling in cystic fibrosis bronchial cells potentiates TNF-α-driven ICAM-1 expression

in Signaling

John Lin
Lyvia Fourcade
Lucie Roussel
Matthew Marabella
Julie Bérubé
Dao Nguyen
Simon Rousseau

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1566482

1,492 views

Original Research

Published on 04 Sep 2025

Multi-transcriptomics analysis of ferroptosis related genes reveals CAFs exosomal COX4I2 as a novel therapeutic target in osteosarcoma

in Signaling

Xiaoying Niu
Xinxin Zhang
Zhongyi Li
Wen Tian

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1620648

3,031 views

Review

Published on 03 Sep 2025

Organoids in biliary research: insights into developmental signaling and applications in disease modeling

in Signaling

Boming Peng
Min Huang
Jianquan Zhang
Yang Xiang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1656019

3,383 views

Original Research

Published on 26 Aug 2025

Slit2 inhibits SRC-PI3K signaling pathway, regulates osteoclast differentiation of macrophages and reduces bone resorption

in Signaling

Qing Ge
Yaokun Zou
Huizhi Deng
Zhe Yang
Linhu Ge
Jieying Huang
Jianqiang Cai
Liping Wang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1632882

2,122 views

Review

Published on 26 Aug 2025

Critical signaling pathways in osteoclast differentiation and bone resorption: mechanisms and therapeutic implications for periprosthetic osteolysis

in Signaling

Liangzi Yin
Chenglin Sun
Junjie Zhang
Yan Li
Yansheng Wang
Lunhao Bai
Zeming Lei

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1639430

3,957 views
1 citation

Review

Published on 22 Aug 2025

The multifaceted roles of E3 ubiquitin ligases in osteoarthritis

in Signaling

Zheng Jin
Zhenhua Zhu
Jun Chen
Xiaopeng Jing
Jie Tan
Ji Zeng

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1665313

1,355 views

Original Research

Published on 20 Aug 2025

Endogenous ligands of bovine FFAR2/GPR43 display distinct pharmacological properties

in Signaling

Tainara Cristina Michelotti
Valérie Lamothe
Frédéric Jean-Alphonse
Eric Reiter
Muriel Bonnet
Guillaume Durand

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1645031

1,680 views

Review

Published on 15 Aug 2025

The role of gut microbiota dysbiosis in drug-induced brain injury: mechanisms and therapeutic implications

in Signaling

Jinghui Zhai
Yue Zhang
Shuyue Ma
Yingli Zhang
Miao Jin
Huiyu Yan
Sixi Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1604539

1,882 views

Opinion

Published on 15 Aug 2025

RAC1 signaling in prostate cancer: VAV GEFs take center stage

in Signaling

Mariana Cooke
Nahuel Peinetti
Marcelo G. Kazanietz
Kerry L. Burnstein

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1658639

1,565 views
1 citation

Original Research

Published on 12 Aug 2025

The lncRNA Jpx participates in testosterone-induced H9c2 cell hypertrophy by targeting the miR-145-5p/Nfatc3 axis

in Signaling

Mingxing Wen
Xinyu Zhang
Litao Tong
Yuhui Chen
Zhengjie Li
Yichen Wang
Can Liu
Jinwei Zhang
Liangpeng Ge
Jing Sun

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1620369

1,322 views

Editorial

Published on 12 Aug 2025

Editorial: Deciphering signaling pathway interactions in tissue homeostasis

in Signaling

John T. Hancock

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1677790

888 views

Correction

Published on 08 Aug 2025

Correction: KRAS and NRF2 drive metabolic reprogramming in pancreatic cancer cells: the influence of oxidative and nitrosative stress

in Signaling

Valentina Rapozzi
Clara Comuzzi
Eros Di Giorgio
Luigi E. Xodo

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1661525

868 views

Review

Published on 08 Aug 2025

The multifaceted impact of physical exercise on FoxO signaling pathways

in Signaling

Wei Liu
Pengjun Meng
Zhi Li
Yifei Shen
Xin Meng
Shen Jin
Mengdi Hu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1614732

4,073 views
2 citations

Original Research

Published on 07 Aug 2025

Protective effects of paederoside in rotenone-induced cellular models of Parkinson’s disease

in Signaling

Juan Lang
Zhongkui Xiong

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1631652

1,598 views

Original Research

Published on 05 Aug 2025

Epigenetic regulation of the respiratory chain by a mitochondrial distress-related redox signal

in Signaling

Marius W. Baeken
Ankush Borlepawar
Philipp Kötzner
Holger Richly
Christian Behl
Bernd Moosmann
Parvana Hajieva

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1608400

3,168 views
1 citation

Original Research

Published on 24 Jul 2025

TRABD maintains mitochondrial homeostasis and protects against ischemia reperfusion-induced renal tubular injury

in Signaling

Wenqi Duan
Wenye Wu
Cui Yang
Mei Zhang
Xuemei Li
Wenmin Tian
Yang Chen
Xinjun Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1619339

1,867 views
1 citation

Editorial

Published on 18 Jul 2025

Editorial: Neuronal guidance signaling in health and neurological diseases

in Signaling

Satoru Yamagishi
Masaki Hiramoto
Junichi Yuasa-Kawada

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1661836

1,208 views

Brief Research Report

Published on 16 Jul 2025

The β-adrenergic receptor-SGK1 signaling pathway in brown adipocytes protects GOT1 from proteasomal degradation

in Signaling

Chul-Hong Park
Minsung Park
J. Jason Collier
Ji Suk Chang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1637770

2,036 views

Review

Published on 10 Jul 2025

Mechanosensitive Piezo channels in mineralized tissues: emerging roles in osteodental adaptation and disease

in Signaling

Junchi Dong
Ran Li
Yuhuang Chen
Guixin Zhu
Xing Liang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1607337

3,781 views

Editorial

Published on 09 Jul 2025

Editorial: Functions and regulation of p90RSK and its family: mechanisms, roles in diseases, and implications in therapeutics

in Signaling

Ling Lin
Nhat-Tu Le
Kebin Hu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1648101

918 views

Review

Published on 09 Jul 2025

The pathogenesis and therapeutic strategies of heat stroke-induced endothelial injury

in Signaling

Shaokang Wang
Xiaoting Zhang
Yongqi Zhang
Nannan Wu
Lulong Bo
Meitang Wang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1569346

3,640 views
2 citations

Review

Published on 04 Jul 2025

Involvement of role of HMGB1-NLRP3 pathway in systemic disorders

in Signaling

Lei Yang
Xue Li
Xiaoming Zhu
Futao Ge
Yuantao Wang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1600596

2,459 views

Review

Published on 02 Jul 2025

Hippo/YAP signaling’s multifaceted crosstalk in cancer

in Signaling

Jie Zhang
Haipeng Wu
Xinxin Ren
Zhuoshi Chen
Siyu Ye
Shuchang Chen
Jie Fang
Qirou Wu
Tiejun Zhao

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1595362

4,946 views
1 citation

Review

Published on 30 Jun 2025

Neuronal guidance behaviours: the primary cilium perspective

in Signaling

Melody Atkins
Coralie Fassier
Xavier Nicol

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1612555

1,945 views

1,269 articles

articles

IL-6 trans-signaling in cystic fibrosis bronchial cells potentiates TNF-α-driven ICAM-1 expression

Multi-transcriptomics analysis of ferroptosis related genes reveals CAFs exosomal COX4I2 as a novel therapeutic target in osteosarcoma

Organoids in biliary research: insights into developmental signaling and applications in disease modeling

Slit2 inhibits SRC-PI3K signaling pathway, regulates osteoclast differentiation of macrophages and reduces bone resorption

Critical signaling pathways in osteoclast differentiation and bone resorption: mechanisms and therapeutic implications for periprosthetic osteolysis

The multifaceted roles of E3 ubiquitin ligases in osteoarthritis

Endogenous ligands of bovine FFAR2/GPR43 display distinct pharmacological properties

The role of gut microbiota dysbiosis in drug-induced brain injury: mechanisms and therapeutic implications

RAC1 signaling in prostate cancer: VAV GEFs take center stage

The lncRNA Jpx participates in testosterone-induced H9c2 cell hypertrophy by targeting the miR-145-5p/Nfatc3 axis

Editorial: Deciphering signaling pathway interactions in tissue homeostasis

Correction: KRAS and NRF2 drive metabolic reprogramming in pancreatic cancer cells: the influence of oxidative and nitrosative stress

The multifaceted impact of physical exercise on FoxO signaling pathways

Protective effects of paederoside in rotenone-induced cellular models of Parkinson’s disease

Epigenetic regulation of the respiratory chain by a mitochondrial distress-related redox signal

TRABD maintains mitochondrial homeostasis and protects against ischemia reperfusion-induced renal tubular injury

Editorial: Neuronal guidance signaling in health and neurological diseases

The β-adrenergic receptor-SGK1 signaling pathway in brown adipocytes protects GOT1 from proteasomal degradation

Mechanosensitive Piezo channels in mineralized tissues: emerging roles in osteodental adaptation and disease

Editorial: Functions and regulation of p90RSK and its family: mechanisms, roles in diseases, and implications in therapeutics

The pathogenesis and therapeutic strategies of heat stroke-induced endothelial injury

Involvement of role of HMGB1-NLRP3 pathway in systemic disorders

Hippo/YAP signaling’s multifaceted crosstalk in cancer

Neuronal guidance behaviours: the primary cilium perspective