Frontiers in Cell and Developmental Biology

Original Research

Published on 07 Jan 2026

XPNPEP2 regulates angiogenesis via modulation of mitochondrial function through SLC25A6

in Signaling

Chenxi Yang
Yijun Lu
Yu Xia
Bingying Wang
Jie Xu
Yuchen Zhang
Jiaxuan Yan
Min Liu
Ting Chen
Xiaoxu Zhao

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1698651

916 views

Review

Published on 06 Jan 2026

Neoantigens in cancer immunoediting: from mechanisms to personalized vaccines in breast cancer

in Signaling

Shiyan Zeng
Li Wang
Wanqin Zeng
Lei Sun

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1733549

1,387 views

Review

Published on 23 Dec 2025

Fibroblast PI3K/AKT signaling and extracellular matrix homeostasis: mechanisms, targets, and delivery challenges

in Signaling

Chunyun Fang
Zitao Zeng
Bin Ni
Xiaochun Wen
Zhipeng Fang
Junrong Zou
Guoxi Zhang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1681875

1,949 views

Editorial

Published on 12 Dec 2025

Editorial: Antioxidants in mitigating oxidative stress-induced damage

in Signaling

Marisol Fernandez-Ortiz
Ramy K. A. Sayed
Russel J. Reiter

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1756697

947 views

Editorial

Published on 10 Dec 2025

Editorial: Ubiquitin proteasome system (UPS) and ubiquitin-independent proteasome-mediated proteolysis (UIPP) crosstalk in development and disease

in Signaling

Michal Sharon
Ralf Stohwasser

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1748172

782 views

Review

Published on 10 Dec 2025

The role of astrocytes in ischemic stroke - mechanisms, functions and treatment

in Signaling

Yunlong Wang
Ding Wang
Dongyu Li
Yuewen Ma

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1700564

1,201 views

Original Research

Published on 01 Dec 2025

Green-synthesized silver nanoparticles from edible plant extracts ameliorate cadmium chloride-induced hepatorenal and testicular toxicity in rats

in Signaling

Akram Abu-Okail
Abdullah S. M. Aljohani
Ayman M. Mousa
Heba A. S. El-Nashar
Mohamed El-Shazly
Ramy K. A. Sayed
Waleed Al Abdulmonem
Mohamed Farghali
Heba F. Kamaly
Ibrahim M. El-Ashmawy

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1677434

2,104 views

Review

Published on 24 Nov 2025

Role of mitochondria-associated membranes (MAMs) in inflammatory signaling: implications for acute lung injury pathogenesis

in Signaling

Huifeng Qian
Guanguan Qiu
Jianguo Xu
Guoping Zheng

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1690934

2,227 views

Review

Published on 21 Nov 2025

Extracellular vesicles in reproductive medicine: from “animal-led” to “plant-enabled”

in Signaling

Keying Pan
Wenhan Ju
Yue Wang
Qianwen Zhang
Ruyi Wang
Xingyue Jiang
Shuai Zhao

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1718643

1,267 views
1 citation

Original Research

Published on 19 Nov 2025

New insights into keloid pathogenesis: biomarker potential for CDK7 and DDB2

in Signaling

Weiqiang Zhang
Fujun Wang
Yixun Zhang
Lusheng Xu
Lujia Mao
Xiaoxiang Wang
Ronghua Yang

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1718189

1,177 views

Original Research

Published on 18 Nov 2025

CLIC1 and CLIC4 demonstrate cell protective antioxidant activity against UV exposure

in Signaling

Khondker Rufaka Hossain
Amani Alghalayini
Daniel R. Turkewitz
Stella M. Valenzuela

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1674374

1,318 views

Review

Published on 11 Nov 2025

Advances in understanding the role of inflammatory factors and immune cells in the pathology of epilepsy, mediated by neuroimmune interactions within the gut-brain axis

in Signaling

Lijia Zhang
Rongjiang Xu
Hao Huang
Juan Yang
Changyin Yu
Haiqing Zhang
Zucai Xu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1650909

2,255 views

Original Research

Published on 10 Nov 2025

Reduced levels of nitrated α-synuclein in the protective effect of harpagoside on rotenone-induced cellular models of Parkinson’s disease

in Signaling

Juan Lang
Zhongkui Xiong

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1624315

1,480 views

Mini Review

Published on 07 Nov 2025

Molecular communication from bone to skeletal muscle: an overview

in Signaling

Guobin Li
Mingyan Qi
Yuzhen Wang
Shibin Liang
Huiyun Xu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1715009

1,753 views

Review

Published on 06 Nov 2025

Signaling pathways and advances in targeted therapy for adenomyosis

in Signaling

Yue Li
Hongyu Zhang
Yaoyao Ding
Yiling Zhao
Yufeng Li
Tiansheng Qin

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1685525

2,171 views

Review

Published on 29 Oct 2025

UPRmt-regulated mitokines: novel strategies for myocardial injury repair

in Signaling

Weinan Gao
Jia Liu
Wenda Zhang
Bin Liu
Luyan Shen

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1652353

2,075 views

Review

Published on 23 Oct 2025

Non-coding RNAs mediate mechanical load-regulating bone metabolic homeostasis

in Signaling

Ruiqi Huang
Bo Chang
Xuejie Yi

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1643255

1,233 views

Review

Published on 23 Oct 2025

Linking signaling dynamics and cell fate decisions through single-cell imaging: evidence and challenges

in Signaling

Fulvio Bonsignore
Sara Pozzi
Erika Aloi
Davide Mazza
Samuel Zambrano

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1656051

2,414 views

Original Research

Published on 16 Oct 2025

Petunidin alleviates diabetic nephropathy injury via the inhibition of oxidative stress and ferroptosis through the Keap1/mitoNQO1 pathway

in Signaling

Yuli Qiu
Chao Chen
Xinyan Li
Yiling Chang
Xiaoqin Zou
Xiaopei Yan
Wenjun Mao
Gang Wu
Su Li
Yuqiong Chen

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1651382

2,006 views

Editorial

Published on 08 Oct 2025

Editorial: Targeting pulmonary endothelium in acute lung injury and acute respiratory distress syndrome

in Signaling

Lulong Bo
You Shang
Guochang Hu

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1714104

1,247 views

Review

Published on 03 Oct 2025

From bench to bedside: therapeutic potential of natural antioxidants in diabetic neuropathy

in Signaling

Yanxian Zhang
Lili Yao
Yongmei Lyu
Zhuqi Tang
Xiaoyu Liu
Xuchu Duan

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1631678

2,755 views

Review

Published on 25 Sep 2025

Osteocytes: master orchestrators of skeletal homeostasis, remodeling, and osteoporosis pathogenesis

in Signaling

Yan Wu
Donghao Gan
Zhikang Liu
Daodi Qiu
Guoqing Tan
Zhanwang Xu
Haipeng Xue

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1670716

7,019 views
3 citations

Original Research

Published on 23 Sep 2025

IL-6 trans-signaling in cystic fibrosis bronchial cells potentiates TNF-α-driven ICAM-1 expression

in Signaling

John Lin
Lyvia Fourcade
Lucie Roussel
Matthew Marabella
Julie Bérubé
Dao Nguyen
Simon Rousseau

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1566482

1,883 views
1 citation

Original Research

Published on 04 Sep 2025

Multi-transcriptomics analysis of ferroptosis related genes reveals CAFs exosomal COX4I2 as a novel therapeutic target in osteosarcoma

in Signaling

Xiaoying Niu
Xinxin Zhang
Zhongyi Li
Wen Tian

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1620648

3,467 views