Frontiers in Chemical Biology | Bioinorganic Chemistry

Original Research

Accepted on 29 Sep 2026

A Metallopeptide Model for the Active Site of Cobalt Nitrile Hydratase Reveals Coupled Metal and Cysteine Oxidation During Active-Site Maturation

in Bioinorganic Chemistry

Irene RAM Ogutu
Callie G. Miller
Nele Hebbeler
Alexander Luong
Adam T. Fiedler
BRIAN BENNETT
Richard C. Holz

Frontiers in Chemical Biology

120 views

Review

Published on 24 Aug 2026

Molecular hydrogen in cancer: reprogramming oncogenic signaling pathways and emerging pharmacological potential

in Bioinorganic Chemistry

Anirban Kumar Maity
Ajay Mallick
Debbie C. Crans
Srikanta Goswami
Soumyajit Roy

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1915345

1,180 views

Review

Published on 10 Jun 2026

Zinc-binding proteins in Alzheimer’s disease: mechanisms, therapeutic potential, and natural compound interventions

in Bioinorganic Chemistry

Riddhi Upadhyay
Susmita Kar
Murugan Sevanan

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1836070

1,677 views
2 citations

Original Research

Published on 05 Jun 2026

Histaminium decavanadate: a small biomimetic model to study non-covalent interactions between decavanadate and histidine side chains in proteins

in Bioinorganic Chemistry

L. F. Paredes-Pérez
N. Sánchez-López
D. Ramírez-Contreras
A. Mendoza
Laura Serrano de la Rosa
M. A. Méndez Rojas
F. J. Melendez
M. E. Castro
E. González-Vergara

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1824850

1,602 views
1 citation

Editorial

Published on 01 Jun 2026

Editorial: Vanadium biochemistry – highlights from the 13th international vanadium symposium

in Bioinorganic Chemistry

Isabel Correia
Debbie C. Crans

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1860732

1,139 views

Original Research

Published on 19 May 2026

Solid-state and solution complexation of dopamine with the silicotungstic Keggin polyoxometalate

in Bioinorganic Chemistry

Fredric G. Svensson
Vadim G. Kessler

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1821236

1,543 views

Editorial

Published on 15 May 2026

Editorial: Chemical biology and coordination chemistry

in Bioinorganic Chemistry

Sylvia M. Draper
Craig C. McLauchlan
Debbie C. Crans

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1864241

1,544 views

Original Research

Published on 13 May 2026

Programmable Ru(II) phototherapeutics: master dials, mode switches, and coligand-controlled reactivity

in Bioinorganic Chemistry

Alisher Talgatov
Gurleen Kaur
Ge Shi
John A. Roque
Patrick C. Barrett
Debby Sunday
Tariq Sainuddin
Susy Kim
Gagan Deep
Antonio Francés-Monerris

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1771939

2,168 views
1 citation

Perspective

Published on 08 May 2026

Electron paramagnetic resonance as a key tool to understand the solution behavior of vanadium compounds: a chemical biology perspective

in Bioinorganic Chemistry

Eugenio Garribba

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1811515

1,830 views
1 citation

Review

Published on 21 Apr 2026

Biological activity of curcumin coordination complexes with second and third-row transition metals

in Bioinorganic Chemistry

Sharon Rosete-Luna
Delia Hernández-Romero
J. Antonio Cruz-Navarro
Esmeralda Sánchez-Pavón
Anell Soto-Contreras
David Morales-Morales
Raúl Colorado-Peralta

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1797518

2,802 views
2 citations

Editorial

Published on 09 Apr 2026

Editorial: Peptide and protein modifications

in Bioinorganic Chemistry

Andrea Ilari
Debbie C. Crans
Antonello Merlino

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1838769

1,325 views
1 citation

Original Research

Published on 26 Mar 2026

Antibacterial potential of mono- Ru(II) and bi-metallic Ru(II)-Mn(II) inorganic compounds with phosphino-fluoroquinolone conjugates

in Bioinorganic Chemistry

Daria Wojtala
Sandra Kozieł
Jakub Łoś
Katarzyna Guz-Regner
Monika K. Lesiów
Magdalena Szmitka
Kacper Kardas
Malwin Bajkowski
Gabriela Bugla-Płoskońska
Urszula K. Komarnicka

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1746130

1,805 views

Original Research

Published on 18 Mar 2026

Ligand-directed assembly of an iminodiacetate-hybridized molybdenum-red isopolyoxomolybdate MoV10MoVI3

in Bioinorganic Chemistry

Ingrid Gregorovic
Emir Al-Sayed
Nadiia I. Gumerova
Judith Füllborn-Ott
Ingo Ott
Gerald Giester
Annette Rompel

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1770808

1,374 views
1 citation

Review

Published on 10 Feb 2026

Zinc-dependent aminopeptidases: new perspectives on structure, function, and biomedical applications

in Bioinorganic Chemistry

Saleem Bhat

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1752191

3,630 views

Original Research

Published on 05 Feb 2026

Design, synthesis, reactivity, and biological activity of nitroimidazole derivatives and their copper(II) coordination compounds

in Bioinorganic Chemistry

Walter Fugarolas
Lorena Reyes-Carmona
Bruno Landeros-Rivera
Argelia Almaguer-Flores
Norah Barba-Behrens

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1736242

2,341 views

Mini Review

Published on 30 Jan 2026

Ferritin-metallodrugs nanocomposites: light and shadow of drugs loading methods

in Bioinorganic Chemistry

Rosanna Lucignano
Giarita Ferraro

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1740075

1,310 views

Original Research

Published on 30 Jan 2026

Redox potential fine tuning of ferrocene-peptide conjugates

in Bioinorganic Chemistry

Alessia Difino
Barbara Biondi
Annalisa Bisello
Roberta Cardena
Luana Lastella
Marko Šimić
Beatrice Calderaro
Fernando Formaggio
Marzio Rancan
Saverio Santi

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1736812

1,767 views

Perspective

Published on 28 Jan 2026

Protein metalation by anticancer metal-based drugs revealed through the integration of ESI-MS and XRD measurements. State of the art and open issues

in Bioinorganic Chemistry

Antonello Merlino
Tiziano Marzo
Luigi Messori

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1758486

1,756 views
3 citations

Mini Review

Published on 22 Jan 2026

Anticancer drugs based on metal complexes of 2-imine-8-hydroxyquinolines

in Bioinorganic Chemistry

Leonor Côrte-Real
Nádia Ribeiro
Isabel Correia

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1734289

2,233 views
3 citations

Perspective

Published on 15 Jan 2026

From simple to complex: multiscale modeling of metal-mediated protein interactions to uncover mechanistic insights into the action of inorganic drugs

in Bioinorganic Chemistry

Lorenzo Chiaverini
Lidia Ciccone
Alessandro Marrone
Luca Famlonga
Davide Piroddu
Nicolò Tonali
Iogann Tolbatov
Jürgen Gailer
Tiziano Marzo
Luigi Messori

Frontiers in Chemical Biology

doi 10.3389/fchbi.2026.1764819

1,935 views

Review

Published on 12 Jan 2026

Receptor-targeted technetium-99m radiopharmaceuticals: increasing access to molecular imaging in healthcare

in Bioinorganic Chemistry

Michelle T. Ma

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1729615

3,613 views
2 citations

Perspective

Published on 05 Jan 2026

Tailoring LC approaches to address the chemical biology of toxic metals in humans

in Bioinorganic Chemistry

Jürgen Gailer

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1729141

1,390 views
2 citations

Mini Review

Published on 19 Dec 2025

The importance of ferric reductases for iron uptake in humans

in Bioinorganic Chemistry

Hitomi Sawai

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1724624

3,532 views
1 citation

Mini Review

Published on 20 Oct 2025

Metals in medicine: unlocking new avenues for neurodegenerative disease treatment

in Bioinorganic Chemistry

Kuan Teng Tan
Kok Whye Cheong
Lai Chun Wong
Hélène C. Bertrand
Nurul Huda Abd Karim
Yie Kie Chong
May Lee Low

Frontiers in Chemical Biology

doi 10.3389/fchbi.2025.1696058

4,269 views
7 citations

47 articles

articles

A Metallopeptide Model for the Active Site of Cobalt Nitrile Hydratase Reveals Coupled Metal and Cysteine Oxidation During Active-Site Maturation

Molecular hydrogen in cancer: reprogramming oncogenic signaling pathways and emerging pharmacological potential

Zinc-binding proteins in Alzheimer’s disease: mechanisms, therapeutic potential, and natural compound interventions

Histaminium decavanadate: a small biomimetic model to study non-covalent interactions between decavanadate and histidine side chains in proteins

Editorial: Vanadium biochemistry – highlights from the 13th international vanadium symposium

Solid-state and solution complexation of dopamine with the silicotungstic Keggin polyoxometalate

Editorial: Chemical biology and coordination chemistry

Programmable Ru(II) phototherapeutics: master dials, mode switches, and coligand-controlled reactivity

Electron paramagnetic resonance as a key tool to understand the solution behavior of vanadium compounds: a chemical biology perspective

Biological activity of curcumin coordination complexes with second and third-row transition metals

Editorial: Peptide and protein modifications

Antibacterial potential of mono- Ru(II) and bi-metallic Ru(II)-Mn(II) inorganic compounds with phosphino-fluoroquinolone conjugates

Ligand-directed assembly of an iminodiacetate-hybridized molybdenum-red isopolyoxomolybdate MoV10MoVI3

Zinc-dependent aminopeptidases: new perspectives on structure, function, and biomedical applications

Design, synthesis, reactivity, and biological activity of nitroimidazole derivatives and their copper(II) coordination compounds

Ferritin-metallodrugs nanocomposites: light and shadow of drugs loading methods

Redox potential fine tuning of ferrocene-peptide conjugates

Protein metalation by anticancer metal-based drugs revealed through the integration of ESI-MS and XRD measurements. State of the art and open issues

Anticancer drugs based on metal complexes of 2-imine-8-hydroxyquinolines

From simple to complex: multiscale modeling of metal-mediated protein interactions to uncover mechanistic insights into the action of inorganic drugs

Receptor-targeted technetium-99m radiopharmaceuticals: increasing access to molecular imaging in healthcare

Tailoring LC approaches to address the chemical biology of toxic metals in humans

The importance of ferric reductases for iron uptake in humans

Metals in medicine: unlocking new avenues for neurodegenerative disease treatment