Frontiers in Dental Medicine | Regenerative Dentistry

Original Research

Published on 12 Jan 2026

Comparative evaluation of the effectiveness of a novel composite bone substitute synthesized from eggshell-derived hydroxyapatite and fish collagen in bone regeneration of critical-sized calvarial defects in Wistar rats

in Regenerative Dentistry

Sruthy Prathap
K. S. Rajesh
Nebu George Thomas
P. K. Binsi
Suprith Surya
M. S. Prathap
Ranajit Das

Frontiers in Dental Medicine

doi 10.3389/fdmed.2025.1731880

310 views

Review

Accepted on 24 Dec 2025

The Tooth Transformer® Revolution: Autologous Dentin Biomaterials and Platelet Concentrates in Oral Regeneration. A Parallel Narrative Systematic Review

in Regenerative Dentistry

Gianna Dipalma
Grazia Marinelli
Laura Ferrante
Irma Trilli
Sharon Di Serio
Paola Bassi
Francesco Inchingolo
Andrea Palermo
Angelo Michele Inchingolo
Alessio Danilo Inchingolo

Frontiers in Dental Medicine

134 views

Mini Review

Published on 11 Dec 2025

Angiogenic regulation of dental pulp stem cells

in Regenerative Dentistry

Waruna Lakmal Dissanayaka
Nunthawan Nowwarote
Tanida Srisuwan
Sirawut Hiran-Us
Chatvadee Kornsuthisopon
Xiaofei Zhu
Thanaphum Osathanon

Frontiers in Dental Medicine

doi 10.3389/fdmed.2025.1717150

624 views

Original Research

Published on 14 Nov 2025

Storage conditions differentially alter the human tooth enamel proteome

in Regenerative Dentistry

Hakan Karaaslan
Baptiste Depalle
Felicitas B. Bidlack

Frontiers in Dental Medicine

doi 10.3389/fdmed.2025.1666534

926 views

Case Report

Published on 06 Nov 2025

Etiology of pulp necrosis as a predictor of success in regenerative endodontics: a case report and bioinformatic analysis

in Regenerative Dentistry

Marcela Alcota
Alfredo Torres
Paulina Ledezma
Montserrat Mercado
Paulina Paredes
Fermín E. González

Frontiers in Dental Medicine

doi 10.3389/fdmed.2025.1664854

1,012 views

Perspective

Published on 27 Oct 2025

Clinical trial landscape for guided bone regeneration: trend analysis and future perspectives

in Regenerative Dentistry

Yuqing Gui
Xinyue Shen
Hongying Li
Junyi Lou
Junjie Cao
Jiang Yu
Zining Luo
Tianxiang Geng
Jiebin Xie

Frontiers in Dental Medicine

doi 10.3389/fdmed.2025.1689513

1,567 views

Review

Published on 09 Oct 2025

The role of neurogenic inflammation in pulp repair and the techniques used for its assessment (narrative review)

in Regenerative Dentistry

Muna Sh. Ahmed
Anas F. Mahdee

Frontiers in Dental Medicine

doi 10.3389/fdmed.2025.1686734

1,918 views

Review

Published on 28 Feb 2025

Insights into the schizophrenia and dental care: focusing on interaction between implant treatments and oxidative stress

in Regenerative Dentistry

Ecaterina Burlui
Viorica Rarinca
Alin Ciobica
Vasile Burlui
Romeo Dobrin
Carmen Stadoleanu

Frontiers in Dental Medicine

doi 10.3389/fdmed.2025.1542913

3,141 views
2 citations

Original Research

Published on 17 Dec 2024

MicroRNA-21-5p profile in the alveolar bone following tooth extraction in medication-related osteonecrosis of the jaw rat model

in Regenerative Dentistry

Manta Morakotsriwan
Theerapat Chanamuangkon
Anjalee Vacharaksa
Pirawish Limlawan

Frontiers in Dental Medicine

doi 10.3389/fdmed.2024.1477274

3,043 views
2 citations

Original Research

Published on 11 Dec 2024

Implant-supported prosthesis under progressive loading protocol stimulates alveolar bone growth in patients with severe alveolar bone atrophy. Retrospective case series

in Regenerative Dentistry

Eduardo Anitua
Laura Piñas
Mohammad H. Alkhraisat

Frontiers in Dental Medicine

doi 10.3389/fdmed.2024.1465137

3,079 views
2 citations

Review

Published on 14 Oct 2024

Role of oxidative stress in impaired type II diabetic bone repair: scope for antioxidant therapy intervention?

in Regenerative Dentistry

Pui Li
Kuraym Khalid Kuraym Alenazi
Jordanna Dally
Emma Louise Woods
Rachel Jane Waddington
Ryan Moseley

Frontiers in Dental Medicine

doi 10.3389/fdmed.2024.1464009

3,464 views
9 citations

Editorial

Published on 11 Sep 2024

Editorial: Impact of uncontrolled diabetes on oral disease progression and healing

in Regenerative Dentistry

Ryan Moseley
Rachel Jane Waddington

Frontiers in Dental Medicine

doi 10.3389/fdmed.2024.1487051

1,726 views

Editorial

Published on 20 May 2024

Editorial: Molecular pathways and novel therapeutic targets in regenerative dentistry

in Regenerative Dentistry

Bruno Cavalcanti
Waruna Lakmal Dissanayaka
Yusuke Takahashi

Frontiers in Dental Medicine

doi 10.3389/fdmed.2024.1426500

1,886 views

Editorial

Published on 01 May 2024

Editorial: Debates in regenerative dentistry

in Regenerative Dentistry

Martha J. Somerman
Paul Sharpe
Pamela C. Yelick
Sema S. Hakki

Frontiers in Dental Medicine

doi 10.3389/fdmed.2024.1412613

1,616 views
1 citation

Correction

Published on 06 Nov 2023

Corrigendum: Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB)

in Regenerative Dentistry

Sesha Hanson-Drury
Anjali P. Patni
Deborah L. Lee
Ammar Alghadeer
Yan Ting Zhao
Devon Duron Ehnes
Vivian N. Vo
Sydney Y. Kim
Druthi Jithendra
Ashish Phal

Frontiers in Dental Medicine

doi 10.3389/fdmed.2023.1278809

2,256 views

Perspective

Published on 09 Oct 2023

NexGen regen? Challenges and opportunities for growth factors and signaling agents in periodontal regeneration at intrabony defects

in Regenerative Dentistry

Maria L. Geisinger

Frontiers in Dental Medicine

doi 10.3389/fdmed.2023.1239149

4,819 views
1 citation

Original Research

Published on 26 Sep 2023

Temperature-responsive PCL-PLLA nanofibrous tissue engineering scaffolds with memorized porous microstructure recovery

in Regenerative Dentistry

Seth M. Woodbury
W. Benton Swanson
Lindsey Douglas
David Niemann
Yuji Mishina

Frontiers in Dental Medicine

doi 10.3389/fdmed.2023.1240397

3,273 views
4 citations

Perspective

Published on 16 Aug 2023

A perspective: Regeneration of soft and hard tissues in the oral cavity, from research to clinical practice

in Regenerative Dentistry

Israel Puterman
Matthew J. Fien
Juan Mesquida
Ignacio Ginebreda
Guillermo Bauza
Martha Somerman

Frontiers in Dental Medicine

doi 10.3389/fdmed.2023.1242547

3,544 views

Clinical Trial

Published on 31 Jul 2023

Effects of Advanced Platelet Rich Fibrin (A-PRF+), Enamel Matrix Derivative (EMD) and Open Flap Debridement on clinical and wound healing parameters in molar furcation sites: A case series from a RCT study

in Regenerative Dentistry

L. Pitzurra
D. Vasdravellis
N.A.M. Rosema
S. Bizzarro
B.G. Loos

Frontiers in Dental Medicine

doi 10.3389/fdmed.2023.1223217

5,686 views
2 citations

Original Research

Published on 26 Jul 2023

An engineered biomaterial to harness the differentiation potential of endogenous human gingival mesenchymal stem cells (hGMSCs)

in Regenerative Dentistry

Mohammad Mahdi Hasani-Sadrabadi
Weihao Yuan
Sevda Sevari
Bo Yu
Sahar Ansari
Alireza Moshaverinia

Frontiers in Dental Medicine

doi 10.3389/fdmed.2023.1235096

2,280 views

Original Research

Published on 20 Jul 2023

Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB)

in Regenerative Dentistry

Sesha Hanson-Drury
Anjali P. Patni
Deborah L. Lee
Ammar Alghadeer
Yan Ting Zhao
Devon Duron Ehnes
Vivian N. Vo
Sydney Y. Kim
Druthi Jithendra
Ashish Phal

Frontiers in Dental Medicine

doi 10.3389/fdmed.2023.1209503

6,745 views
3 citations

Original Research

Published on 26 Jun 2023

Hyperglycemia exerts disruptive effects on the secretion of TGF-β1 and its matrix ligands, decorin and biglycan, by mesenchymal sub-populations and macrophages during bone repair

in Regenerative Dentistry

Norhayati Yusop
Ryan Moseley
Rachel J. Waddington

Frontiers in Dental Medicine

doi 10.3389/fdmed.2023.1200122

3,161 views
4 citations

Editorial

Published on 21 Jun 2023

Editorial: Species diversity in evolution and replacement of teeth informing clinical therapies

in Regenerative Dentistry

Christopher A. McCulloch

Frontiers in Dental Medicine

doi 10.3389/fdmed.2023.1225665

1,823 views

Editorial

Published on 26 May 2023

Editorial: Frontiers in Dental Medicine: highlights in regenerative dentistry 2021/22

in Regenerative Dentistry

Waruna Lakmal Dissanayaka
Paul Sharpe

Frontiers in Dental Medicine

doi 10.3389/fdmed.2023.1212894

1,991 views
2 citations

63 articles

articles

Comparative evaluation of the effectiveness of a novel composite bone substitute synthesized from eggshell-derived hydroxyapatite and fish collagen in bone regeneration of critical-sized calvarial defects in Wistar rats

The Tooth Transformer® Revolution: Autologous Dentin Biomaterials and Platelet Concentrates in Oral Regeneration. A Parallel Narrative Systematic Review

Angiogenic regulation of dental pulp stem cells

Storage conditions differentially alter the human tooth enamel proteome

Etiology of pulp necrosis as a predictor of success in regenerative endodontics: a case report and bioinformatic analysis

Clinical trial landscape for guided bone regeneration: trend analysis and future perspectives

The role of neurogenic inflammation in pulp repair and the techniques used for its assessment (narrative review)

Insights into the schizophrenia and dental care: focusing on interaction between implant treatments and oxidative stress

MicroRNA-21-5p profile in the alveolar bone following tooth extraction in medication-related osteonecrosis of the jaw rat model

Implant-supported prosthesis under progressive loading protocol stimulates alveolar bone growth in patients with severe alveolar bone atrophy. Retrospective case series

Role of oxidative stress in impaired type II diabetic bone repair: scope for antioxidant therapy intervention?

Editorial: Impact of uncontrolled diabetes on oral disease progression and healing

Editorial: Molecular pathways and novel therapeutic targets in regenerative dentistry

Editorial: Debates in regenerative dentistry

Corrigendum: Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB)

NexGen regen? Challenges and opportunities for growth factors and signaling agents in periodontal regeneration at intrabony defects

Temperature-responsive PCL-PLLA nanofibrous tissue engineering scaffolds with memorized porous microstructure recovery

A perspective: Regeneration of soft and hard tissues in the oral cavity, from research to clinical practice

Effects of Advanced Platelet Rich Fibrin (A-PRF+), Enamel Matrix Derivative (EMD) and Open Flap Debridement on clinical and wound healing parameters in molar furcation sites: A case series from a RCT study

An engineered biomaterial to harness the differentiation potential of endogenous human gingival mesenchymal stem cells (hGMSCs)

Single cell RNA sequencing reveals human tooth type identity and guides in vitro hiPSC derived odontoblast differentiation (iOB)

Hyperglycemia exerts disruptive effects on the secretion of TGF-β1 and its matrix ligands, decorin and biglycan, by mesenchymal sub-populations and macrophages during bone repair

Editorial: Species diversity in evolution and replacement of teeth informing clinical therapies

Editorial: Frontiers in Dental Medicine: highlights in regenerative dentistry 2021/22