Frontiers in Immunology | Multiple Sclerosis and Neuroimmunology

Original Research

Accepted on 27 Jan 2026

Identification of plasma inflammatory biomarkers for Alzheimer's disease reveals IFN-γ as a regulator of ACSL1-mediated microglia phenotype

in Multiple Sclerosis and Neuroimmunology

Ronghua Huang
Bing-Biao Lin
Zhijie Lu
Yixuan Hao
Chenrui Li
Zixian Lin
Yingjie Zhang
Naili Wei
Jian Chen

Frontiers in Immunology

398 views

Review

Published on 27 Jan 2026

Immune crosstalk in Alzheimer’s and Parkinson’s disease: insights from Drosophila models into the brain–peripheral immune axis

in Multiple Sclerosis and Neuroimmunology

Faiza Parvez
Rahul

Frontiers in Immunology

doi 10.3389/fimmu.2026.1725046

713 views

Original Research

Published on 27 Jan 2026

CyTOF profiling identifies location-specific peripheral immune checkpoint and immune cell subset in mild ischemic stroke

in Multiple Sclerosis and Neuroimmunology

Hang Hang
Yang Yao
Likun Wang
Cuiying Liu
Jing Zhao
Baohui Xu
Heng Zhao
Guofeng Wu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1739324

784 views

Review

Published on 27 Jan 2026

Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization

in Multiple Sclerosis and Neuroimmunology

Weidong Lai
Xin Tang
Sijia Chen
Yihan Zhou
Zihan Qi
Menglei Cao
Cunrui Yuan
Jie Yu
Chengping Wen

Frontiers in Immunology

doi 10.3389/fimmu.2026.1677310

577 views

Review

Published on 26 Jan 2026

Deep cervical lymph node analysis in central nervous system inflammatory disease

in Multiple Sclerosis and Neuroimmunology

Alexis Elena Giff
Mattia Wruble Clark
Shamik Bhattacharyya
Peter T. Sage
Bruno Madore
Jeffrey P. Guenette
Edison K. Miyawaki

Frontiers in Immunology

doi 10.3389/fimmu.2026.1747114

1,654 views

Editorial

Published on 22 Jan 2026

Editorial: The role of inflammasome in neuroinflammation and neurodegeneration

in Multiple Sclerosis and Neuroimmunology

Suhua Chang
Yushan Guan
Qinrui Li
Pin Wan
Yongkui Li
Jinbiao Liu

Frontiers in Immunology

doi 10.3389/fimmu.2026.1768702

818 views

Systematic Review

Published on 21 Jan 2026

Mapping the immune and epigenetic landscape of medication-overuse headache (MOH): a systematic review

in Multiple Sclerosis and Neuroimmunology

Nanna Elman Andersen
Marta Waliszewska-Prosół
Lanfranco Pellesi

Frontiers in Immunology

doi 10.3389/fimmu.2026.1756442

833 views

Brief Research Report

Published on 15 Jan 2026

Macrophage-targeted PEGylated liposomes ameliorate experimental autoimmune encephalomyelitis

in Multiple Sclerosis and Neuroimmunology

Alexander Muselman
Lewis W. Yu
Khoa D. Nguyen
Mohammed Inayathullah
Qiang Liu
Kyle D. Brewer
Andrey V. Malkovskiy
Jayakumar Rajadas
Edgar G. Engleman

Frontiers in Immunology

doi 10.3389/fimmu.2025.1657131

963 views

Original Research

Published on 14 Jan 2026

Disproportionality analysis of satralizumab in FDA adverse event reporting system and Japanese adverse drug event report: a pharmacovigilance study

in Multiple Sclerosis and Neuroimmunology

Linhai Zhang
Rong Yan
Zucai Xu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1647306

996 views

Original Research

Published on 14 Jan 2026

Diagnostic biomarkers for differentiating AQP4-IgG- negative NMOSD from other nervous system autoimmune disorders: a retrospective study

in Multiple Sclerosis and Neuroimmunology

Wencan Jiang
Yang Jiao
Menglue Zhang
Chenxu Wang
Xiaotong Li
Kelin Chen
Yaowei Ding
Haoran Li
Lijuan Wang
Siwen Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1637613

1,045 views

Correction

Published on 13 Jan 2026

Correction: Morphometric MRI findings in patients with suspected autoimmune psychosis spectrum syndromes and association with EEG slowing, CSF changes, and psychometric/neuropsychological findings

in Multiple Sclerosis and Neuroimmunology

Frontiers Production Office

Frontiers in Immunology

doi 10.3389/fimmu.2025.1755844

644 views

Original Research

Accepted on 12 Jan 2026

Interrogation of glioma immune microenvironment identifies a noncanonical role for microglial Galectin-9 in tumor cell adhesion and phagocytosis

in Multiple Sclerosis and Neuroimmunology

Pravesh Gupta
Silvana Valdebenito-Silva
Gayatri Kumar
Prashanth Chakrapani
Shivangi Oberai
Minghao Dang
Hiroshi Katyama
Linghua Wang
Eliseo A Eugenin
Krishna Bhat

Frontiers in Immunology

260 views

Mini Review

Published on 12 Jan 2026

The gut microbiota influences neurodegenerative diseases through the gut-brain axis: molecular mechanisms and effects on immune function

in Multiple Sclerosis and Neuroimmunology

Jiaheng Yang
Xiangzhun Song
Su Yan
Qianxun Li
Wenying Yang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1739329

1,236 views

Original Research

Published on 12 Jan 2026

Outcomes and predictors of relapse and severe pneumonia in Chinese patients with AQP4-IgG-positive neuromyelitis optica spectrum disorder receiving inebilizumab: a prospective cohort study

in Multiple Sclerosis and Neuroimmunology

Wenjuan Huang
Hongmei Tan
Jingzi ZhangBao
Liang Wang
Yuxin Fan
Zhouzhou Wang
Chongbo Zhao
Jiahong Lu
Qiang Dong
Lei Zhou

Frontiers in Immunology

doi 10.3389/fimmu.2025.1718896

926 views

Original Research

Published on 12 Jan 2026

Single-cell transcriptome-wide Mendelian randomization identifies mitochondrial targets in immune cells for Major Depressive Disorder

in Multiple Sclerosis and Neuroimmunology

Yangyi Zhang
Fei Zhang
Xingyi Shen
Maoyuan Ni
Jiayi Zhang
Shunling Zhang
Jingwen Lin
Zhaoyang Yang
Huangwei Lei

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700604

967 views

Review

Published on 09 Jan 2026

Engineering neuroimmune regulation: biomaterial and nanotechnology platforms for neuropathology diagnosis and targeted immunomodulation

in Multiple Sclerosis and Neuroimmunology

Mikayla S. Jackson
Lauren G. Porter
Robert S. Oakes

Frontiers in Immunology

doi 10.3389/fimmu.2025.1677612

1,351 views

Review

Published on 09 Jan 2026

From arthritis to central sensitization: targeting the neuro-immune axis via microglial modulation in acupuncture treatment for Juvenile Idiopathic Arthritis–associated pain

in Multiple Sclerosis and Neuroimmunology

Hang Chen
Jixiang Xu
Xia Zhang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1684060

1,121 views

Case Report

Published on 08 Jan 2026

B-cell–driven relapse and anti-CD20 rescue therapy after Alemtuzumab in RRMS: case report and literature review

in Multiple Sclerosis and Neuroimmunology

Pietro Antonio Bruno
Stefania Barone
Angelo Pascarella
Pier Luigi Lanza
Emanuele Tinelli
Antonio Gambardella
Paola Valentino

Frontiers in Immunology

doi 10.3389/fimmu.2025.1710669

1,213 views

Original Research

Published on 07 Jan 2026

Clinical characteristics and prognosis of paraneoplastic syndromes: a single-center cohort study in Northern China

in Multiple Sclerosis and Neuroimmunology

Minzhe Hu
Qianchang Wang
Yuxiu Xiao
Danqing Qin
Shougang Guo
Chunjuan Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1715164

951 views

Original Research

Published on 06 Jan 2026

Dysregulated Tfh/B cells and their interactions in neuromyelitis optica spectrum disorder

in Multiple Sclerosis and Neuroimmunology

Liang Wang
Lei Zhou
Zhouzhou Wang
Jingzi ZhangBao
Wenjuan Huang
Hongmei Tan
Yuxin Fan
Chuanzhen Lu
Jian Yu
Min Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1704282

1,096 views

Original Research

Published on 05 Jan 2026

Serum visfatin in multiple sclerosis: distinct profiles in healthy controls, naive patients, and treated RRMS

in Multiple Sclerosis and Neuroimmunology

Saltanat Mert
İbrahim Acır
Hümeyra Öztürk Emre
Kübra Balcı
Edanur Demir

Frontiers in Immunology

doi 10.3389/fimmu.2025.1641260

843 views

Clinical Trial

Published on 05 Jan 2026

Patient-reported improvements from use of IMC-2 alone and IMC-2 and Paxlovid® in a Long COVID cohort: a case series

in Multiple Sclerosis and Neuroimmunology

William L. Pridgen
David Putrino

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698271

12,315 views

Original Research

Published on 02 Jan 2026

Immune imbalance in the human hippocampus in PTSD revealed by single-nucleus transcriptomics

in Multiple Sclerosis and Neuroimmunology

Liu Liu
Pengfei Li
Brent A. Wilkerson
Yan Wu
Meng Liu
Roger Shi
Eric D. Hamlett
Steven L. Carroll
Amanda C. LaRue
Zhewu Wang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1697171

1,348 views

Original Research

Published on 02 Jan 2026

The immunomodulating effect of palmitoylethanolamide on human myeloid dendritic cells and its possible impact on Alzheimer’s disease

in Multiple Sclerosis and Neuroimmunology

Iliana Piccolino
Filomena Iannuzzi
Ludovica Lionetti
Benedetta Mazzonello
Valeria Barreca
Nerisa Banaj
Valentina Arezzini
Fabrizio Piras
Paola Bossù

Frontiers in Immunology

doi 10.3389/fimmu.2025.1664164

1,595 views

1,513 articles

articles

Identification of plasma inflammatory biomarkers for Alzheimer's disease reveals IFN-γ as a regulator of ACSL1-mediated microglia phenotype

Immune crosstalk in Alzheimer’s and Parkinson’s disease: insights from Drosophila models into the brain–peripheral immune axis

CyTOF profiling identifies location-specific peripheral immune checkpoint and immune cell subset in mild ischemic stroke

Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization

Deep cervical lymph node analysis in central nervous system inflammatory disease

Editorial: The role of inflammasome in neuroinflammation and neurodegeneration

Mapping the immune and epigenetic landscape of medication-overuse headache (MOH): a systematic review

Macrophage-targeted PEGylated liposomes ameliorate experimental autoimmune encephalomyelitis

Disproportionality analysis of satralizumab in FDA adverse event reporting system and Japanese adverse drug event report: a pharmacovigilance study

Diagnostic biomarkers for differentiating AQP4-IgG- negative NMOSD from other nervous system autoimmune disorders: a retrospective study

Correction: Morphometric MRI findings in patients with suspected autoimmune psychosis spectrum syndromes and association with EEG slowing, CSF changes, and psychometric/neuropsychological findings

Interrogation of glioma immune microenvironment identifies a noncanonical role for microglial Galectin-9 in tumor cell adhesion and phagocytosis

The gut microbiota influences neurodegenerative diseases through the gut-brain axis: molecular mechanisms and effects on immune function

Outcomes and predictors of relapse and severe pneumonia in Chinese patients with AQP4-IgG-positive neuromyelitis optica spectrum disorder receiving inebilizumab: a prospective cohort study

Single-cell transcriptome-wide Mendelian randomization identifies mitochondrial targets in immune cells for Major Depressive Disorder

Engineering neuroimmune regulation: biomaterial and nanotechnology platforms for neuropathology diagnosis and targeted immunomodulation

From arthritis to central sensitization: targeting the neuro-immune axis via microglial modulation in acupuncture treatment for Juvenile Idiopathic Arthritis–associated pain

B-cell–driven relapse and anti-CD20 rescue therapy after Alemtuzumab in RRMS: case report and literature review

Clinical characteristics and prognosis of paraneoplastic syndromes: a single-center cohort study in Northern China

Dysregulated Tfh/B cells and their interactions in neuromyelitis optica spectrum disorder

Serum visfatin in multiple sclerosis: distinct profiles in healthy controls, naive patients, and treated RRMS

Patient-reported improvements from use of IMC-2 alone and IMC-2 and Paxlovid® in a Long COVID cohort: a case series

Immune imbalance in the human hippocampus in PTSD revealed by single-nucleus transcriptomics

The immunomodulating effect of palmitoylethanolamide on human myeloid dendritic cells and its possible impact on Alzheimer’s disease