Frontiers in Immunology | NK and Innate Lymphoid Cell Biology

Original Research

Accepted on 13 Feb 2026

Automated manufacturing of clinical-grade BDCA2 CAR NK cells in a closed system for the treatment of blastic plasmacytoid dendritic cell neoplasm

in NK and Innate Lymphoid Cell Biology

Rita Pfeifer
Sabine Müller
Marcus Nitsche
Melanie Sohmen
Julia Kostyra
Arthur Bister
Cathrin Bleilevens
Janina Brauner
Angela Mekes
Juliane Raasch

Frontiers in Immunology

Original Research

Accepted on 11 Feb 2026

Interaction between NKG2D and its ligands MICA/B activates the DAP12/SYK/p53/p21 axis to drive pulmonary fibrosis

in NK and Innate Lymphoid Cell Biology

caiping zhao
hong ren
qingming ke
qiuzhu chen
Jinlian He
ruimin tian
Hudan Pan
liang liu

Frontiers in Immunology

104 views

Original Research

Published on 27 Jan 2026

Development and computational analysis of high dimensional spectral flow cytometry data for the resolution of innate lymphoid cells in the mammary tumor microenvironment

in NK and Innate Lymphoid Cell Biology

Hobin Seo
Jingna Xue
Qiutong Huang
Megan Kinzel
Amisha Verma
Ngan Huynh
Zahra Jamila Ikra
Douglas J. Mahoney
Jongbok Lee
Sorana Morrissy

Frontiers in Immunology

doi 10.3389/fimmu.2026.1730567

704 views

Original Research

Published on 26 Jan 2026

Association of NK cells with a shift in tryptophan catabolism in patients with heart failure after a single exercise exertion

in NK and Innate Lymphoid Cell Biology

Krithika Swaminathan
Bita Astan
Sabine Kaczmarek
Kristin Lehnert
Anke Hannemann
Aycen Koc
Nele Friedrich
Kathrin Budde
Ann-Kristin Henning
Grażyna Domańska

Frontiers in Immunology

doi 10.3389/fimmu.2025.1732461

917 views

Correction

Published on 15 Jan 2026

Correction: Perspective: IL-15 cytokine-armored NK cells as ready-to-use immunotherapy for diverse malignancies: therapeutic potential and toxicity risks

in NK and Innate Lymphoid Cell Biology

Scott L. Baughan
Timothy Folsom
Matt Johnson
Joshua Kreuger
Beau R. Webber
Branden S. Moriarity

Frontiers in Immunology

doi 10.3389/fimmu.2026.1779800

463 views

Original Research

Published on 13 Jan 2026

Umbilical cord blood natural killer cells for adoptive immunotherapy: identifying optimal starting material and processing parameters

in NK and Innate Lymphoid Cell Biology

M. G. Kennedy
W. Patterson
S. T. Cox
L. Wynn
C. Stock da Cunha
M. O’Dwyer
R. Danby
D. Hernandez

Frontiers in Immunology

doi 10.3389/fimmu.2025.1734453

1,589 views

Original Research

Published on 12 Jan 2026

Construction of anti-HER2 affibody-directed CAR-NK and its synergistic effects with doxorubicin-loaded nanodrug against HER2-positive breast cancer

in NK and Innate Lymphoid Cell Biology

Xuesong He
Zhaoyuan Liang
Qing Liu
Xiaofei Zhang
Hao Liang
Runqing Jia
Wang Sheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1692107

964 views

Review

Published on 12 Jan 2026

Natural killer cell-based senotherapy: a promising strategy for healthy aging

in NK and Innate Lymphoid Cell Biology

Tsutomu Nakazawa
Ryo Yamanishi
Takayuki Morimoto
Ryosuke Matusda

Frontiers in Immunology

doi 10.3389/fimmu.2025.1737572

1,385 views

Original Research

Published on 12 Jan 2026

Multi-omics integration identifies NK cell dysregulation and a five-gene diagnostic signature in major depressive disorder

in NK and Innate Lymphoid Cell Biology

Jia Wang
Ye Kuang
Chuanmei Peng
Yong Yuan
Yong Ji
Sulian Chen
Jinrong Tian
Yuanyuan Zhou
Xingying Chen
Jing Li

Frontiers in Immunology

doi 10.3389/fimmu.2025.1700629

990 views

Correction

Published on 05 Jan 2026

Correction: Genetic polymorphisms in cGAS-STING-mediated type I interferon innate immune signaling pathway are associated with DLBCL

in NK and Innate Lymphoid Cell Biology

Qirui Zhou
Ruinan Jia
Jinlin Chen
Yang Tan
Yuechan Ma
Mengfan Luan
Xue Sheng
Xiao Han
Shuying Li
Fei Lu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1773500

581 views

Original Research

Published on 05 Jan 2026

Impact of absolute lymphocyte count upon admission to ICU on 28-day mortality in sepsis patients in ICU

in NK and Innate Lymphoid Cell Biology

DingJun Zhong
Ling Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1688451

1,034 views

Original Research

Published on 17 Dec 2025

A novel fully human anti-ROR1 antibody PBA-0405 optimized for ADCC, induces potent anti-tumor activity against both solid and hematological malignancies

in NK and Innate Lymphoid Cell Biology

Niina Veitonmäki
Anna Kostyn
Sonia Kołt
Aleksandra Ziemblicka
Beata Romanowska
Sabina Oleksy
Ewelina Krzywińska
Kamilla Sołtys
Łukasz Świderski
Piotr Naporowski

Frontiers in Immunology

doi 10.3389/fimmu.2025.1711509

2,655 views

Original Research

Published on 16 Dec 2025

Genetic polymorphisms in cGAS-STING-mediated type I interferon innate immune signaling pathway are associated with DLBCL

in NK and Innate Lymphoid Cell Biology

Qirui Zhou
Ruinan Jia
Jinlin Chen
Yang Tan
Yuechan Ma
Mengfan Luan
Xue Sheng
Xiao Han
Shuying Li
Fei Lu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1725218

1,733 views

Original Research

Published on 12 Dec 2025

2B4 co-stimulation and dasatinib modulation enhance anti-CD19 CAR-NK-92 cell cytotoxicity

in NK and Innate Lymphoid Cell Biology

Matheus Henrique dos Santos
Júlia Teixeira Cottas de Azevedo
Mara Elisama da Silva Januário
Dayane de Fátima Schmidt
Mariane Cariati Tirapelle
Alison Felipe Bordini Biggi
Sima Ebrahimabadi
Renata Nacasaki Silvestre
Dimas Tadeu Covas
Rodrigo T. Calado

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675877

2,321 views
1 citation

Methods

Published on 10 Dec 2025

A 41-marker 37-color full spectrum flow cytometry panel for the deep immunophenotyping of human peripheral and liver natural killer cells

in NK and Innate Lymphoid Cell Biology

Alberta Gerarda Antonia Paul
Konrad H. H. Reichel
Juan J. Garcia-Vallejo
Lara R. Heij
Maria C. Jaimes
Yacine Kharraz

Frontiers in Immunology

doi 10.3389/fimmu.2025.1609732

3,048 views

Original Research

Published on 10 Dec 2025

Insomnia and anxiety: exploring their hidden effect on natural killer cells among young female adults

in NK and Innate Lymphoid Cell Biology

Renad M. Alhamawi
Fatmah A. Halawani
Sima F. Hakeem
Hadeel A. Alslimi
Ebraheim M. Alhamawi
Ahmed M. Aljohani
Ibrahim N. Mohammed
Heba M. Zahid
Yahya A. Almutawif

Frontiers in Immunology

doi 10.3389/fimmu.2025.1698155

5,349 views

Perspective

Published on 19 Nov 2025

Perspective: IL-15 cytokine-armored NK cells as ready-to-use immunotherapy for diverse malignancies: therapeutic potential and toxicity risks

in NK and Innate Lymphoid Cell Biology

Scott L. Baughan
Timothy Folsom
Matt Johnson
Joshua Kreuger
Beau R. Webber
Branden S. Moriarity

Frontiers in Immunology

doi 10.3389/fimmu.2025.1704404

3,403 views
1 citation

Original Research

Published on 05 Nov 2025

Tofacitinib extends survival in a mouse model of ALS through NK cell-independent mechanisms

in NK and Innate Lymphoid Cell Biology

Lillia A. Baird
Samuel J. Teener
Ian F. Webber-Davis
Andrew D. Carter
Fang Huang
Dae-Gyu Jang
Joshua P. Famie
Caroline E. Piecuch
Kai Guo
Eva L. Feldman

Frontiers in Immunology

doi 10.3389/fimmu.2025.1662197

2,164 views

Original Research

Published on 05 Nov 2025

TGF-β-driven NK Cells plasticity in hepatocellular carcinoma

in NK and Innate Lymphoid Cell Biology

Valentina Reverberi
Anna Montali
Andrea Vecchi
Marzia Rossi
Alessio Pelagatti
Sara Doselli
Benedetta Farina
Andrea Olivani
Giorgio Economopoulos
Raffaele Dalla Valle

Frontiers in Immunology

doi 10.3389/fimmu.2025.1651129

2,052 views

Original Research

Published on 24 Oct 2025

Comparative transcriptomic analysis of tumor- infiltrating canine natural killer cells and candidate biomarkers from first-in-dog NK immunotherapy trials

in NK and Innate Lymphoid Cell Biology

Aryana M. Razmara
Marshall Lammers
Sean J. Judge
Cyrus J. Sholevar
William J. Murphy
Cameron E. Gaskill
William T. N. Culp
Alicia A. Gingrich
Zachary S. Morris
Robert B. Rebhun

Frontiers in Immunology

doi 10.3389/fimmu.2025.1646849

1,789 views

Systematic Review

Published on 23 Oct 2025

New hope for the treatment of recurrent and refractory psoriasis: NK cell immunotherapy—A scientometric analysis

in NK and Innate Lymphoid Cell Biology

Li Chen
Lin Cheng

Frontiers in Immunology

doi 10.3389/fimmu.2025.1656398

5,337 views

Review

Published on 22 Oct 2025

Crosstalk between decidual natural killer cells and extravillous trophoblasts at the maternal-fetal interface: current status and future perspectives

in NK and Innate Lymphoid Cell Biology

Yeqi Qiu
Mingye Chen
Rong Lin
Xiaoyan Chen
Lichun He
Hui Yin
Xian Chen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1703156

2,186 views

Review

Published on 16 Oct 2025

Beyond CAR-T Cells: exploring CAR-NK, CAR-M, and CAR-γδ T strategies in solid tumor immunotherapy

in NK and Innate Lymphoid Cell Biology

Yingjie Hou
Shihua Hu
Chong Liu
Xin Chen
Yuru Wang
Youzherui Li
Zihe Fu
Chunjing Feng
Yanhua Gong
Zichuan Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1675807

10,049 views
11 citations

Original Research

Published on 07 Oct 2025

Dynamics of NK cell subsets following autologous hematopoietic stem cell transplantation in adult oncologic patients

in NK and Innate Lymphoid Cell Biology

Gabirel Astarloa-Pando
Victor Sandá
Ainhoa Amarilla-Irusta
Ainara Lopez-Pardo
Itxaso San Juan
Ainhoa Iturbe-Larrondo
Raquel Pérez-Garay
Silvia Pérez-Fernández
Borja Santos-Zorrozúa
Bárbara Manzanares-Martín

Frontiers in Immunology

doi 10.3389/fimmu.2025.1629118

4,280 views

828 articles

articles

Automated manufacturing of clinical-grade BDCA2 CAR NK cells in a closed system for the treatment of blastic plasmacytoid dendritic cell neoplasm

Interaction between NKG2D and its ligands MICA/B activates the DAP12/SYK/p53/p21 axis to drive pulmonary fibrosis

Development and computational analysis of high dimensional spectral flow cytometry data for the resolution of innate lymphoid cells in the mammary tumor microenvironment

Association of NK cells with a shift in tryptophan catabolism in patients with heart failure after a single exercise exertion

Correction: Perspective: IL-15 cytokine-armored NK cells as ready-to-use immunotherapy for diverse malignancies: therapeutic potential and toxicity risks

Umbilical cord blood natural killer cells for adoptive immunotherapy: identifying optimal starting material and processing parameters

Construction of anti-HER2 affibody-directed CAR-NK and its synergistic effects with doxorubicin-loaded nanodrug against HER2-positive breast cancer

Natural killer cell-based senotherapy: a promising strategy for healthy aging

Multi-omics integration identifies NK cell dysregulation and a five-gene diagnostic signature in major depressive disorder

Correction: Genetic polymorphisms in cGAS-STING-mediated type I interferon innate immune signaling pathway are associated with DLBCL

Impact of absolute lymphocyte count upon admission to ICU on 28-day mortality in sepsis patients in ICU

A novel fully human anti-ROR1 antibody PBA-0405 optimized for ADCC, induces potent anti-tumor activity against both solid and hematological malignancies

Genetic polymorphisms in cGAS-STING-mediated type I interferon innate immune signaling pathway are associated with DLBCL

2B4 co-stimulation and dasatinib modulation enhance anti-CD19 CAR-NK-92 cell cytotoxicity

A 41-marker 37-color full spectrum flow cytometry panel for the deep immunophenotyping of human peripheral and liver natural killer cells

Insomnia and anxiety: exploring their hidden effect on natural killer cells among young female adults

Perspective: IL-15 cytokine-armored NK cells as ready-to-use immunotherapy for diverse malignancies: therapeutic potential and toxicity risks

Tofacitinib extends survival in a mouse model of ALS through NK cell-independent mechanisms

TGF-β-driven NK Cells plasticity in hepatocellular carcinoma

Comparative transcriptomic analysis of tumor- infiltrating canine natural killer cells and candidate biomarkers from first-in-dog NK immunotherapy trials

New hope for the treatment of recurrent and refractory psoriasis: NK cell immunotherapy—A scientometric analysis

Crosstalk between decidual natural killer cells and extravillous trophoblasts at the maternal-fetal interface: current status and future perspectives

Beyond CAR-T Cells: exploring CAR-NK, CAR-M, and CAR-γδ T strategies in solid tumor immunotherapy

Dynamics of NK cell subsets following autologous hematopoietic stem cell transplantation in adult oncologic patients