Frontiers in Immunology | Parasite Immunology

Original Research

Published on 17 Jul 2025

Red pulp macrophages clear parasites, while marginal metallophilic and marginal zone macrophages support CD4+ T cell activation during Plasmodium yoelii infection

in Parasite Immunology

Julia Falkenstein
Anne Ninnemann
Matthias Hose
Abdelrahman Elwy
Karl S. Lang
Kai Matuschewski
Jan Buer
Astrid M. Westendorf
Wiebke Hansen

Frontiers in Immunology

doi 10.3389/fimmu.2025.1607201

347 views

Original Research

Published on 17 Jul 2025

Amblyostatin-1, the first salivary cystatin with host immunomodulatory and anti-inflammatory properties from the Neotropical tick Amblyomma sculptum, vector of Brazilian spotted fever

in Parasite Immunology

Wilson Santos Molari
Mohamed Amine Jmel
Josiane Betim Assis
Alan Frazão-Silva
Júlia Moura Bernardi
Gretta Huamanrayme
José María Medina
Eliane Esteves
Solange Cristina Antão
Gabriel Cerqueira Alves Costa

Frontiers in Immunology

doi 10.3389/fimmu.2025.1585703

275 views

Original Research

Published on 17 Jul 2025

Hyperglycemia enhances group B Streptococcus pathogenicity by impairing TLR2 expression and chemotactic response in the human placenta

in Parasite Immunology

Rodrigo Jiménez-Escutia
Arumi Villafuerte-Pérez
Donovan Vargas-Alcantar
Karina Martínez-Garfias
Samara Rodríguez-Flores
Pilar Velázquez-Sánchez
Amaury Fortanel-Fonseca
Rodrigo Zamora-Escudero
Marcela Islas-López
Ismael Mancilla-Herrera

Frontiers in Immunology

doi 10.3389/fimmu.2025.1610381

243 views

Mini Review

Accepted on 14 Jul 2025

Targeting macrophage phenotypes to prevent diseases caused by Leishmania and Trypanosoma cruzi infections

in Parasite Immunology

Natália Vellozo
Thayane Conceição Matos-Silva
Marcela Freitas Lopes

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595954

171 views

Original Research

Accepted on 14 Jul 2025

Protein dysregulation during Leishmania infantum infection in anti-TNF immunosuppressed mice revealed through quantitative proteomics analysis of extracellular vesicles

in Parasite Immunology

Lorena Bernardo
Ana Montero Calle
Jose Carlos Solana
Marina Lozano-Rendal
Ana Torres
Carmen Sánchez
Rodrigo Barderas
Javier Moreno
Eugenia Carrillo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1634080

Original Research

Published on 14 Jul 2025

IDO1-AhR axis increases T regulatory cells in Plasmodium vivax malaria infection

in Parasite Immunology

Rafaella Oliveira dos Santos
Nani Oliveira Carvalho
Thiago Barros do Nascimento de Morais
Wlademir Braga Salgado Sobrinho
Maria Geuziane Soares da Cruz
Elaine Speziali de Faria
Fernanda Fortes de Araújo
Vanessa Peruhype Magalhães
Stefanie Costa Pinto Lopes
Adriana Malheiros

Frontiers in Immunology

doi 10.3389/fimmu.2025.1474447

851 views

Original Research

Published on 14 Jul 2025

Exploring the P. falciparum antigens associated with reduced risk of malaria in pregnancy

in Parasite Immunology

Lucy Mwai
Sebastian Musundi
Harrison Waweru
Hikaru Nagaoka
Purity Gacheri Limbua
Takafumi Tsuboi
Eizo Takashima
Jesse Gitaka
Bernard N. Kanoi

Frontiers in Immunology

doi 10.3389/fimmu.2025.1622435

559 views

Original Research

Published on 11 Jul 2025

Evaluation of the immunoprotective potential of recombinant EtMIF as a subunit vaccine candidate against Eimeria tenella infection in chickens

in Parasite Immunology

Rui Bai
Hui Wang
Jiale Guo
Yang Pei
Yongbin Li
Shuying Zhu
Chenyang Lv
Jianhui Li
Xiaozhen Cui
Xiaoling Lv

Frontiers in Immunology

doi 10.3389/fimmu.2025.1623743

398 views

Original Research

Accepted on 09 Jul 2025

Larval ascariasis elicits a prominent IgA and IgG1/2 antibody response to adult Ascaris excretory/secretory antigens in pigs

in Parasite Immunology

Zaneta Darlene Musimbi
Alexandra Laubschat
Larissa Oser
Robert Mugendi Mugo
Philipp Höfler
Josephine Schlosser-Brandenburg
Ankur Midha
Sebastian Rausch
Susanne Hartmann

Frontiers in Immunology

doi 10.3389/fimmu.2025.1606128

130 views

Original Research

Published on 09 Jul 2025

Toxoplasma gondii virulence in mice is determined by the pseudokinase ROP5B and countered by an IRG-GBP protein interplay

in Parasite Immunology

Shishir Singh
Mateo Murillo-León
Aura María Bastidas Quintero
Florence Melbert
Klaus Pfeffer
Daniel Degrandi
Tobias Steinfeldt

Frontiers in Immunology

doi 10.3389/fimmu.2025.1593785

688 views

Original Research

Published on 07 Jul 2025

R21/Matrix-M malaria vaccine drives diverse immune responses in pre-exposed adults: insights from a phase IIb controlled human malaria infection trial

in Parasite Immunology

Elizabeth Kibwana
Caroline Bundi
Domtila Kimani
Lydia Nyamako
Kelvias Keter
Agnes Mutiso
Rodney Ogwang
Duncan Bellamy
Katerina Rapi
Amelia Bajer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620365

829 views

Original Research

Published on 02 Jul 2025

Development of high affinity antibodies to Plasmodium falciparum merozoite and sporozoite antigens during infancy and adulthood

in Parasite Immunology

Allan Lugaajju
Richard Idro
Stephen Kiwuwa
James G. Beeson
Damien R. Drew
Susanne E. Mortazavi
Sara Linse
Kristina E. M. Persson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1562671

918 views

Original Research

Published on 26 Jun 2025

Vaccine-induced responses to R21/Matrix-M – an analysis of samples from a phase 1b age de-escalation, dose-escalation trial

in Parasite Immunology

Caroline Bundi
Duncan Bellamy
Elizabeth Kibwana
Lydia Nyamako
Rodney Ogwang
Kelvias Keter
Domtila Kimani
Ahmed M. Salman
Samuel Provstgaard-Morys
Lisa Stockdale

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620366

1,345 views

Original Research

Published on 24 Jun 2025

Dual single-cell and bulk RNA sequencing reveal transcriptional profiles underlying heterogenous host-parasite interactions in human peripheral blood mononuclear cells

in Parasite Immunology

Praveena Chandrasegaran
Bekir Faydaci
Barbara Shih
Musa A. Hassan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1582645

1,169 views

Original Research

Published on 23 Jun 2025

PLGA nanoparticles as an efficient carrier in Toxoplasma GAP45: a more effective vaccine against acute toxoplasmosis than traditional ones

in Parasite Immunology

Pan Zhou
YanLi Yu
WeiYu Qi
XiaoJuan Wang
YouLi Yu
JianDong Wang
Li Zhang
ZhengQing Yu
TingLi Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600399

876 views

Original Research

Published on 20 Jun 2025

Splenic macrophage functional profile and its role in the immunopathogenesis of canine visceral leishmaniasis

in Parasite Immunology

Tainã Luís de Souza
Marta de Almeida Santiago
Francini Neves Ribeiro
Fabiano Borges Figueiredo
Artur Augusto Velho Mendes Junior
Rodrigo Caldas Menezes
Renato Porrozzi
Fernanda Nazaré Morgado

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617751

1,044 views