Frontiers in Immunology | Parasite Immunology

Original Research

Published on 23 Jun 2025

PLGA nanoparticles as an efficient carrier in Toxoplasma GAP45: a more effective vaccine against acute toxoplasmosis than traditional ones

in Parasite Immunology

Pan Zhou
YanLi Yu
WeiYu Qi
XiaoJuan Wang
YouLi Yu
JianDong Wang
Li Zhang
ZhengQing Yu
TingLi Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1600399

Original Research

Published on 20 Jun 2025

Splenic macrophage functional profile and its role in the immunopathogenesis of canine visceral leishmaniasis

in Parasite Immunology

Tainã Luís de Souza
Marta de Almeida Santiago
Francini Neves Ribeiro
Fabiano Borges Figueiredo
Artur Augusto Velho Mendes Junior
Rodrigo Caldas Menezes
Renato Porrozzi
Fernanda Nazaré Morgado

Frontiers in Immunology

doi 10.3389/fimmu.2025.1617751

359 views

Original Research

Accepted on 18 Jun 2025

Amblyostatin-1, the first salivary cystatin with host immunomodulatory and anti-inflammatory properties from the Neotropical tick Amblyomma sculptum, vector of Brazilian spotted fever

in Parasite Immunology

Wilson Santos Molari
Mohamed Amine Jmel
Josiane Betim de Assis
Alan Frazão Silva
Júlia de Moura Bernardi
Gretta Huamanrayme Bustamante
José María Medina
Eliane Esteves
Solange Antão Antão
Andréa Cristina Fogaça

Frontiers in Immunology

doi 10.3389/fimmu.2025.1585703

Original Research

Accepted on 18 Jun 2025

Development of high affinity antibodies to Plasmodium falciparum merozoite and sporozoite antigens during infancy and adulthood

in Parasite Immunology

Allan Lugaajju
Richard Idro
Stephen Kiwuwa
James G Beeson
Damien R Drew
Susanne E Mortazavi
Sara Linse
Kristina E M Persson

Frontiers in Immunology

doi 10.3389/fimmu.2025.1562671

Original Research

Accepted on 17 Jun 2025

R21/Matrix-M Malaria Vaccine Drives Diverse Immune Responses in Pre-Exposed Adults: Insights from a Phase IIb Controlled Human Malaria Infection Trial

in Parasite Immunology

Elizabeth Kibwana
Caroline Bundi
Domtila KIMANI
Lydia Nyamako
Kelvias Keter
Agnes Mutiso
Rodney Ogwang
Duncan Bellamy
Katerina Rapi
Amelia Bajer

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620365

158 views

Original Research

Published on 17 Jun 2025

Interferons and Toxoplasma gondii shape PD-L1 regulation in retinal barrier cells: the critical role of proteases

in Parasite Immunology

Benjamin Geiller
Camila Cevallos
Iuliia Tsybenko
Lydia Arnoux
Marie-Paule Felder-Schmittbuhl
Alexander W. Pfaff

Frontiers in Immunology

doi 10.3389/fimmu.2025.1607247

479 views

Original Research

Accepted on 13 Jun 2025

Non-additive strong gene interactions cause striking differences in organ pathology and cytokine response in leishmaniasis

in Parasite Immunology

Yahya Sohrabi
Tatyana Kobets
Valeriya Volkova
Eliska Javorkova
Imtissal Krayem
Alena Zajicova
Helena Havelkova
Milena Svobodova
Vladimir Holan
Peter Demant

Frontiers in Immunology

doi 10.3389/fimmu.2025.1579257

164 views

Original Research

Accepted on 10 Jun 2025

Mice Mucosal Leishmaniasis model shown high parasite load, increased cytotoxicity and impaired IL-10 + T cell response

in Parasite Immunology

Alisson Amaral Da-Rocha
Julio Souza Dos-Santos
Igor Santos Bittencourt
Douglas Barroso De-Almeida
Naiara Carla Santos Manhaes
Hozany Praxedes
Joao Victor Paiva Romano
Elias Barbosa Silva-Junior
Antonio Jose Silva-Goncalves
Marcia Pereira L Oliveira

Frontiers in Immunology

doi 10.3389/fimmu.2025.1621781

169 views

Original Research

Published on 09 Jun 2025

Dual roles of Anisakis pegreffii proteins in macrophage immune dynamics

in Parasite Immunology

Min-hao Zeng
Sarah Alsobaie
Xiao-xu Wang
Shan Li
Fahad M. Aldakheel
Mourad A. M. Aboul-Soud
Wei-bin Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1595093

709 views

General Commentary

Published on 09 Jun 2025

Commentary: Induction of hepatic fibrosis in mice with schistosomiasis by extracellular microRNA-30 derived from Schistosoma japonicum eggs

in Parasite Immunology

Haoran Zhong
Yamei Jin

Frontiers in Immunology

doi 10.3389/fimmu.2025.1604905

586 views

Original Research

Accepted on 06 Jun 2025

IDO1-AhR axis increases T regulatory cells in Plasmodium vivax malaria infection

in Parasite Immunology

Rafaella Oliveira dos Santos
Nani Oliveira Carvalho
Thiago Barros do Nascimento de Morais
Wlademir Braga Salgado Sobrinho
Maria Geuziane Soares da Cruz
Elaine Speziali de Faria
Fernanda Fortes De Araújo
Vanessa Peruhype Pascoal
Stefanie Costa Pinto Lopes
Adriana Malheiros

Frontiers in Immunology

doi 10.3389/fimmu.2025.1474447

489 views

Case Report

Published on 05 Jun 2025

Case Report: Disseminated leishmaniasis and rheumatoid arthritis: navigating a clinical conundrum

in Parasite Immunology

Endrit Shahini
Donatello Marziliano
Francesco Losito
Marianna Zappimbulso
Elisabetta Cavalcanti
Raffaele Armentano
Fabio Fucilli
Raffaele Cozzolongo
Giuseppe Ingravallo
Fabrizio Pappagallo

Frontiers in Immunology

doi 10.3389/fimmu.2025.1599381

1,002 views

Original Research

Accepted on 02 Jun 2025

Toxoplasma gondii virulence in mice is determined by the pseudokinase ROP5B and countered by an IRG-GBP protein interplay

in Parasite Immunology

Shishir Singh
Mateo Murillo-León
Aura Maria Bastidas Quintero
Florence Melbert
Klaus Pfeffer
Daniel Degrandi
Tobias Steinfeldt

Frontiers in Immunology

doi 10.3389/fimmu.2025.1593785

254 views

Original Research

Accepted on 28 May 2025

Dual single-cell and bulk RNA sequencing reveal transcriptional profiles underlying heterogenous host-parasite interactions in human peripheral blood mononuclear cells

in Parasite Immunology

Praveena R G Chandrasegaran
Barbara Shih
Musa Hassan

Frontiers in Immunology

doi 10.3389/fimmu.2025.1582645

215 views

Original Research

Accepted on 27 May 2025

Vaccine-induced responses to R21/Matrix-M -an analysis of samples from a phase 1b age de-escalation, dose-escalation trial

in Parasite Immunology

Caroline Bundi
Duncan Bellamy
Elizabeth Kibwana
Lydia Nyamako
Rodney Ogwang
Kelvias Keter
Domtila KIMANI
Ahmed M Salman
Samuel Provstgaard-Morys
Lisa Stockdale

Frontiers in Immunology

doi 10.3389/fimmu.2025.1620366

364 views

Original Research

Published on 27 May 2025

Emu-miR-10a-5p in Echinococcus multilocularis-derived-extracellular vesicles alleviates airway inflammation in mice with allergic asthma by inhibiting macrophage M2a polarization through LIF-mediated JAK1–STAT3 signaling

in Parasite Immunology

Yunzhuo Xin
Rou Wen
Dong Song
Jing Xiao
Xiaoping Gao
Mei Yin
Yanli Bai
Jie Wang
Xiangyu Zhou
Jiaqing Zhao

Frontiers in Immunology

doi 10.3389/fimmu.2025.1577349

1,192 views