ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition, Psychology and Brain Health
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1493603
This article is part of the Research TopicUnraveling the Associations Between Diet and Mental HealthView all 9 articles
Association Between Dietary Selenium Intake and Depression in Patients With or Without Stroke: A Cross-Sectional Study
Provisionally accepted
- 1Department of Neurology, The Affiliated Hospital of Jianghan University, Wuhan, China
- 2Department of Neurosurgery, General Hospital of the Yangtze River Shipping, Wuhan, China
- 3Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, Hubei Province, China
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Background: Depression and stroke are life-threatening diseases with high incidence, research suggests an interaction between dietary selenium and depression and stroke. However, the relationship between dietary selenium and depression has not been adequately studied. Therefore, the purpose of this study was to assess the association between dietary selenium and depression among individuals with or without stroke.A cross-sectional study was performed using the 2011-2018 National Health and Nutrition Examination Survey dataset (N = 15,018). Logistic regression, interaction effect analysis, and restricted cubic spline analysis were used for statistical analyses.The association between dietary selenium intake and prevalence depression differed between the non-stroke and stroke groups. Furthermore, when dietary selenium was converted into a categorical variable, there was evidence of an interaction between stroke status and selenium intake on decreasing the prevalence of depression (P = 0.007). What's more, the dose-response association between dietary selenium intake and depression indicated various patterns between participants with and without stroke.A cross-sectional study cannot be used to infer causal relationships.A non-linear relationship was observed in individuals without stroke, characterized by an apparent threshold of approximately 128.4 mcg/d. In contrast, no association was observed between dietary selenium intake and depression in participants with stroke. Further research is necessary to validate the present findings.
Keywords: dietary, Selenium, Depression, National Health and Nutrition Examination, Stroke
Received: 09 Sep 2024; Accepted: 21 May 2025.
Copyright: © 2025 Wu, Mei, Gao and Chai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Songshan Chai, Department of Neurosurgery, Zhongnan Hospital, Wuhan University, Wuhan, 430071, Hubei Province, China
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