ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1521239
The impact of percutaneous endoscopic gastrostomy on nutritional status and survival in cervical esophageal cancer patients undergoing chemoradiotherapy
Provisionally accepted
- 中山大学肿瘤防治中心, 广州市, China
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Objective: This retrospective study aimed to study the effects of percutaneous endoscopic gastrostomy (PEG) on nutritional status and overall survival (OS) of cervical esophageal cancer (CEC) patients who received concurrent chemoradiotherapy.Methods: Thirty-four CEC patients who underwent concurrent chemoradiotherapy (CCRT) were retrospectively reviewed. A series of nutritional indicators: controlling nutritional status (CONUT) score, weight, body mass index, albumin, lymphocyte counts, hemoglobin (HGB) was introduced to evaluate the nutritional status between patients with or without PEG.Results: Among the 34 patients, 18 received PEG placement (PEG group) and 16 did not (Non-PEG group). The median survival for the PEG group was 38.0 months (range, 6.0-60.3), and for the Non-PEG group, it was 43.5 months (range, 21.5-162.8). The two-year, three-year, and four-year OS rates for the PEG group were 81.9% (95% confidence interval [CI]: 63.2-100%), 54.3% (95% CI: 25.5-83.1%), and 32.6% (95% CI: 0.0-63.6%), respectively, while the Non-PEG group had two-year, threeyear, and four-year OS rates of 100% (95% CI: 83.0-100%), 82.1% (95% CI: 59.2-100%), and 49.2% (95% CI: 11.4-87.0%), respectively. There was no significant difference in the OS between the PEG group and the Non-PEG group (p = 0.095, hazard ratio [HR] 0.398, 95% [CI] 0.135-1.173). In the nutritional index, changes in HGB were significantly correlated with PEG (p = 0.016). Multivariate analysis results showed: weight loss ≥5% (p = 0.041, HR = 5.664, 95% CI: 1.075-29.846) and a CONUT score ≥4 (p = 0.01, HR = 15.223, 95% CI: 1.935-119.783) were independent prognostic factors for OS.Conclusions: Weight loss during chemoradiotherapy and higher CONUT scores may decrease the OS rate for CEC patients. However, PEG insertion did not affect the OS rate.
Keywords: Cervical esophageal squamous cell carcinoma, Percutaneous endoscopic gastrostomy, CONUT score, Body Mass Index, overall survival
Received: 01 Nov 2024; Accepted: 10 Jun 2025.
Copyright: © 2025 Wen, Chen, Huang, Liu, Xiao, Zhou and Zhong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lihui Chen, 中山大学肿瘤防治中心, 广州市, China
Zhongying Huang, 中山大学肿瘤防治中心, 广州市, China
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