ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1525115
This article is part of the Research TopicAssessment of Nutritional Status in Chronic DiseasesView all 23 articles
Association of Advanced Lung Cancer Inflammation Index with All-Cause and Cardiovascular Mortality in US Patients with Asthma
Provisionally accepted
- 1Department of Emergency Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- 2Peking Union Medical College Hospital (CAMS), Beijing, Beijing Municipality, China
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Background: Asthma poses a significant global health challenge, representing a chronic respiratory disorder marked by airway inflammation. The advanced lung cancer inflammation index (ALI) served as a comprehensive index to assess inflammation. However, few studies have investigated the association between ALI and both all-cause and cardiovascular mortality in US patients with asthma.We used data from the National Health and Nutrition Examination Survey (NHANES) to explore the association of ALI with all-cause and cardiovascular mortality in US patients with asthma.This study used Kaplan-Meier curves to examine the ALI index's impact on asthma patients' survival.We applied weighted Cox models and restricted cubic splines (RCS) analysis to assess the ALImortality link, identifying nonlinear thresholds with a recursive algorithm. Subgroup analyses and sensitivity analyses were conducted, excluding those with missing covariates and cancer patients.Results: 6211 asthma patients were enrolled and categorized into three groups based on ALI tertiles.The risk of all-cause mortality decreased as ALI increased in the fully adjusted multivariate Cox regression analysis; the hazard ratio is 0.95 ( 95% CI: 0.91~0.99, P = 0.01 ). Compared with the lowest ALI group, T1, the fully adjusted HR values for ALI and all-cause mortality in T2, T3 were 0.68 ( 95% CI: 0.55-0.85, P < 0.001), 0.53 ( 95% CI: 0.41-0.68, P < 0.001 ). The risk of cardiovascular mortality was also lower in the groups of T2 (HR: 0.84, 95% CI: 0.55-1.28) and T3 (HR: 0.47, 95%CI: 0.31-0.71, P for trend <0.001), respectively. In addition, the results of the subgroup analyses were robust. Conclusions: This cohort study demonstrated the higher accuracy of ALI in predicting mortality in asthma patients, highlighting its important clinical value of ALI in risk assessment and prognosis evaluation.
Keywords: Asthma, Inflammation, Advanced lung cancer inflammation index, NHANES, Mortality
Received: 08 Nov 2024; Accepted: 12 Jun 2025.
Copyright: © 2025 LI, LIU and XU. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: BIN XU, Department of Emergency Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
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