ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition, Psychology and Brain Health
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1533683
This article is part of the Research TopicNutrition and Mood DisordersView all 9 articles
Relationship between nocturia, depression, and cognitive function and the mediating effects of nutritional indexes in older adults: data from NHANES 2011-2014
Provisionally accepted
- 960th Hospital of the PLA, Jinan, China
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Purpose: This study evaluated the correlation between nocturia, depression, and cognitive function in older adults and the mediating effect of albumin and hemoglobin on this correlation.Methods: Data on nocturia, depression, and cognitive function from the National Health and Nutrition Examination Survey 2011-2014 were analyzed by multiple logistic regression.Results: The digit symbol score (DSS) and 9-Item Patient Health Questionnaire (PHQ-9) scores were linearly and non-linearly correlated with nocturia risk (p < 0.05). Male/female-stratified analysis showed that animal fluency scores (AFS), DSS, and PHQ-9 scores were significantly correlated with the risk of nocturia in females (p < 0.05), and PHQ-9 scores were significantly associated with the risk of nocturia in males (p < 0.05). Albumin partially mediated the association of AFS, DSS, and PHQ-9 scores with nocturia risk in women and the relationship of PHQ-9 scores with nocturia risk in men. Hemoglobin partially mediated the relationship of AFS and DSS with nocturia risk in women and the association of PHQ-9 scores with nocturia risk in men.Conclusion: Nocturia is positively associated with depression and cognitive impairment in older adults, especially in women. Nutrition partially mediates the relationship between nocturia, depression, and cognitive function. Thus, improving nutrition may decrease the risk of nocturia in older adults.
Keywords: nocturia, cognitive function, depression, older adults, albumin, hemoglobin Abbreviations: ALB, albumin, AFS, animal fluency score, DSS, digit symbol scores, DSST, digit symbol substitution test, DWRS, delayed word recall score, HGB, hemoglobin, IRS, immediate recall score, MEC, Mobile Examination Center
Received: 24 Nov 2024; Accepted: 02 Jun 2025.
Copyright: © 2025 Xu, Wang, Wang, Wei and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wei Wei, 960th Hospital of the PLA, Jinan, China
Ning Li, 960th Hospital of the PLA, Jinan, China
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