ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1541661
This article is part of the Research TopicPreventative Medicine: Nutritional and Lifestyle Interventions for Healthy Ageing and Chronic DiseasesView all 40 articles
Oxidative Balance and Survival in Osteoporosis: How Antioxidant Diets and Lifestyles Reduce Mortality Risk
Provisionally accepted
- 1Xuzhou Medical University, Xuzhou, China
- 2The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China
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Background: Osteoporosis (OP) is a global health issue characterized by reduced bone mineral density (BMD) and an elevated risk of fractures. Oxidative stress is implicated in OP pathogenesis, and antioxidant diets and lifestyles may mitigate these effects. This research aims to investigate the correlation between oxidative balance score (OBS) and all-cause mortality in individuals diagnosed with OP.: This study is based on data from the National Health and Nutrition Examination Survey (NHANES, 2005-2018), which covers 776 OP patients aged 50 or older. OBS was computed using dietary and lifestyle factors, and divided into two categories: dietary oxidative balance score (DOBS) and lifestyle oxidative balance score (LOBS). Participants were grouped into tertiles based on OBS values.Results: Kaplan-Meier survival analysis revealed significantly higher survival in the high OBS group compared to the low OBS group (P = 0.0032). Consistently, weighted Cox proportional hazards models demonstrated a negative association between OBS and all-cause mortality (HR = 0.96, 95% CI [0.94, 0.99], P = 0.0036).OBS is inversely correlated with all-cause mortality among OP patients, underscoring the critical role of antioxidant-rich diets and lifestyle modifications in OP prevention and treatment strategies.Incorporating OBS into clinical practice may help identify high-risk individuals and guide targeted interventions to reduce mortality risk.
Keywords: Osteoporosis, Oxidative balance score, antioxidant diet, mortality risk, Tenth Revision PIR: Poverty Income Ratio CVD: Cardiovascular Disease kNN: k-nearest neighbor RCS: Restricted Cubic Spline
Received: 08 Dec 2024; Accepted: 26 Jun 2025.
Copyright: © 2025 Ding, Qi, Li, Chen, Li, Sun, Sun, Feng and Yuan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Feng Yuan, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province, China
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