ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1549089
This article is part of the Research TopicDietary Habits in Liver Health and Disease: Preclinical and Clinical StudiesView all 16 articles
Association of Life's Crucial 9 with metabolic dysfunctionassociated steatotic liver disease: the mediating role of neutrophil-percentage-to-albumin ratio
Provisionally accepted
- 1Beijing Ditan Hospital, Capital Medical University, Beijing, China
- 2Beijing Ditan Hospital, capital medical university, Beijing, China
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Background: The development of metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with cardiovascular health (CVH) status and chronic inflammation. Life's Crucial 9 (LC9) is the most recent index to assess CVH; its association with MASLD and liver fibrosis is unclear. This study aimed to investigate the association of LC9 with MASLD and hepatic fibrosis, and to reveal for the first time the mediating role of a novel inflammatory marker, neutrophil-albumin percentage (NPAR), in the association between LC9 and MASLD. Methods: This study was a cross-sectional analysis of data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. The United States Fatty Liver Index (US-FLI) ≥30 was used to diagnose MASLD, and liver stiffness measurements (LSM) >8.2 defined liver fibrosis. Weighted multifactorial regression, the association between LC9 and MASLD (P<0.001).Conclusions: Good CVH status (high LC9 score) was associated with lower prevalence of MASLD and liver fibrosis, and NPAR partially mediated the association between LC9 and MASLD. This study provides new epidemiological evidence for preventing MASLD by improving CVH and inflammatory modulation.
Keywords: Life's Crucial 9, MASLD, liver fibrosis, NPAR, NHANES, mediation analysis Characteristic Overall, N = 43, 115
Received: 20 Dec 2024; Accepted: 14 May 2025.
Copyright: © 2025 Zhu, Li, Lin, Cui and Xin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Li Xin, Beijing Ditan Hospital, Capital Medical University, Beijing, China
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