ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1553133
Associations between Feeding Patterns and Clinical Outcomes of Hirschsprung's Disease after Surgery: Propensity Score Matching Approach
Provisionally accepted
- Children‘s Hospital of Chongqing Medical University, Chongqing, China
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Background: Feeding pattern is closely related to physical development and health, but the benefit of breast feeding on clinical outcomes of Hirschsprung's disease (HSCR) remains unknown. This study aimed to investigate the influences of feeding patterns on postoperative outcomes of HSCR using propensity score matching (PSM) analysis.Methods: The clinical data of 296 patients with HSCR who underwent Laparoscopic-assisted pull-through surgery were retrospectively analyzed. Patients were dichotomized into breast and formula feeding groups.Using propensity score matching (PSM), the two groups were compared for baseline differences and postoperative outcomes. Furthermore, Univariate/multivariate Logistic regression analysis was used to identify feeding pattern as an independent factor of postoperative HAEC and bowel dysfunction.Results: Of the 296 patients, breast feeding was 73% (216/296). After PSM, patients with formula feeding had higher rates of postoperative undernutrition (risk of malnutrition: 21.05% vs. 8.77%; malnutrition: 28.07% vs. 15.79%, P=0.023), HAEC (47.37% vs. 22.81%, P =0.006), and bowel dysfunction (64.29% vs.42.11%, P =0.018). Multivariate Logistic regression analysis revealed that formula feeding was an independent risk factor for postoperative HAEC (OR [95% CI]=6. 86 [1.76 ~26.79]) and bowel dysfunction (OR [95% CI]=2.88 [1.06 ~7.83]).Conclusions: Following adjustment for patient characteristics, HSCR patients with breast feeding were associated with lower rates of postoperative undernutrition, HAEC, and bowel dysfunction.
Keywords: Feeding pattern, clinical outcome, Hirschsprung's disease, Propensity score matching, Logistic regression analysis
Received: 30 Dec 2024; Accepted: 20 Jun 2025.
Copyright: © 2025 Feng, Xiang, Die, Hou, Guo, Liu, Hou and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wei Feng, Children‘s Hospital of Chongqing Medical University, Chongqing, China
Yi Wang, Children‘s Hospital of Chongqing Medical University, Chongqing, China
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