ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1554743
This article is part of the Research TopicKetogenic Metabolic Therapies in Prevention & Treatment of Non-communicable DiseasesView all 13 articles
From Glucose to Histone Modification: Sex-Specific Metabolic Responses to Ketogenic Therapy in VM/Dk Mice
Provisionally accepted
- 1Morsani College of Medicine, USF Health, Tampa, Florida, United States
- 2Direct Care and Wellness Treatment, Brooksville, United States
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The assessment of sex-specific effects in pre-clinical models is critical for improving the translatability of findings to clinical applications. However, preclinical studies often combine sexes or focus exclusively on one sex, including research utilizing syngeneic cancer models. Considering sex differences is particularly important in metabolic studies, as males and females exhibit distinct body compositions, hormone profiles, and metabolic demands. This study evaluates sex-specific metabolic responses to ketogenic therapies in VM/Dk mice, including assessments of glucose metabolism, ketone metabolism, and histone modifications linked to metabolism. Our findings reveal significant sex differences in body weight, circulating metabolites, blood insulin levels, and histone modification profiles. Additionally, we demonstrate that male and female VM/Dk mice respond differently to ketogenic therapies, with responses varying based on the specific type of therapy applied.
Keywords: ketone metabolic therapy, exogenous ketones, epigentic, Metabolic therapy, Insulin
Received: 02 Jan 2025; Accepted: 20 May 2025.
Copyright: © 2025 Moss, Poff, Moss, DeBlasi and D'Agostino. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dominic P D'Agostino, Morsani College of Medicine, USF Health, Tampa, 33612, Florida, United States
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