ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1554840
This article is part of the Research TopicMaternal Metabolic Health: From Preconception to PostpartumView all 8 articles
Association between blood essential metal elements in early pregnancy and gestational diabetes mellitus
Provisionally accepted
- Guangdong Province Women and Children Hospital, Guangzhou, China
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The purpose was to assess the levels of iron (Fe), magnesium (Mg), copper (Cu), calcium (Ca), zinc (Zn) in the blood of pregnant women during early pregnancy, and to evaluate their potential association with gestational diabetes mellitus (GDM).We enrolled 9112 pregnant women who underwent testing for essential metal elements at Guangdong Maternal and Child Health Hospital during the first trimester in 2015-2022. The basic information of pregnant women and peripheral blood samples were collected, and five essential metal elements in whole blood were detected by atomic absorption spectrometry. The relationship between these essential metal elements and GDM was analyzed using the generalized linear regression model (GLM), weighted quantile sum regression (WQS), quantile g-computation regression (QGC), and bayesian kernel machine regression (BKMR).Results: Analysis of the correlation between essential metal elements and GDM revealed significant associations. Compared with the first quantile concentration level,
Keywords: essential metal elements, gestational diabetes mellitus, Inflammatory indicators, Mixed exposure, Mediation
Received: 03 Jan 2025; Accepted: 26 May 2025.
Copyright: © 2025 Chen, Wu, Ji, Xia and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Guozhen Chen, Guangdong Province Women and Children Hospital, Guangzhou, China
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