ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1558342
The association of triglyceride glucose waist-to-height ratio index with depression in United States adults
Provisionally accepted
- People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, China
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Objective: The purpose of this study is to investigate the relationship between the triglyceride-glucose waist-to-height ratio (TyG-WHtR) and depression. Methods: Data were used from the National Health and Nutrition Examination Survey (NHANES) that was conducted between 2005 and 2018, which included 15,630 eligible people. Based on a PHQ score of more than 10, the participants were each assigned to one of two groups: a group of depressed individuals (n=1347) and a group of non-depressed individuals (n=14,283). To investigate the connection between TyG-WHtR and depression, one-way comparative analyses and multifactorial logistic regression were carried out, and subgroup analyses were also used. To do more research into this connection, quartile grouping was used, and restricted cubic spline (RCS) curves were utilized to evaluate the patterns that emerged in the relationship between TyG-WHtR and depression.Results: An independent and substantial positive correlation between TyG-WHtR and depression was found by multifactorial logistic regression of the data. In the fully corrected model, TyG-WHtR levels were associated with a higher prevalence of depression (OR=1.19, 95%:1.09-1.29). Analysis of TyG-WHtR quartiles showed a significant trend in Q4 compared to Q1 (trend p < 0.001). There is a linear connection between TyG-WHtR and depression. From the RCS curve, we can see that its threshold is 5.07. From the ROC curve, we know that the predictive value of TyG-WtHR is higher than that of BMI. Subgroup analyses indicated significant interactions with diabetes, marital status, education, and body mass index (BMI).Conclusion: Depressive symptoms are significantly associated with TyG-WHtR, which is a strong positive correlation. This index may provide useful insights for the diagnosis and treatment of depression as related research continues to advance.
Keywords: Triglyceride-glucose waist-to-height ratio, Depression, triglyceride-glucose, Insulin Resistance, NHANES
Received: 10 Jan 2025; Accepted: 13 Jun 2025.
Copyright: © 2025 Zhang, Li, Zhang, Wang, Tuerhong and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qin Luo, People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, China
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