ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutritional Epidemiology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1561712
The Burden of Gallbladder and Biliary Tract Cancer in Global, Regional and National from 2010 to 2021 for Aged 55 Years and OlderGlobal, Regional, and National Burden of Gallbladder and Biliary Tract Cancer Among Adults Aged 55 Years and Older, 2010-2021
Provisionally accepted
Guoqing Ouyang1,2*
Ming juan Li1
Jiaguang Li2
Shuang Li1,2Jiahui Zhao1
Tao Gan2Min Wu1
Shunwen Luo1
Yunying Liang1
秋云 李1Guangdong Pan1,2Jianqing Yang1,2*- 1Liuzhou Key Laboratory of Liver Cancer Research, Liuzhou People’s Hospital, Liuzhou, Guangxi, China
- 2Liuzhou People's Hospital, Liuzhou, Guangxi Zhuang Region, China
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Introduction: Gallbladder and Biliary Tract Cancer (GBTC) accounts for a notable proportion of cancer cases worldwide. This study aims to assess the burden of GBTC among aged 55 years and older, enhancing our understanding of its trends and their relationship with Socio-Demographic Index(SDI) across regions and countries. Methods: We used the data from the Global Burden of Disease study from 2010 to 2021 to analyze GBTC incidence, death numbers, disability-adjusted life years (DALYs) and their respective rates for individuals aged 55 years and older. We also reported the GBTC percentage trend during this period. Results: The global incidence and death cases of GBTC changed significantly between 2010 and 2021. Compared to 2010, GBTC incidence and deaths increased by 35.9% and 29.7% individually in 2021. High-income Asia Pacific was the region with the highest age-standardized incidence, deaths, and DALYs in 2021, and China was the country with the largest number of incidence cases, deaths, and DALYs in 2021. Furthermore, the highest age-standardized incidence rate and age-standardized death rate occurred in Japan. Among individuals aged 55 years and older, the highest incident and death cases were observed in 70-74 age group, and females were more suffered from GBTC than males between 2010 and 2021. Conclusion: GBTC remains a substantial and growing global health burden, particularly among females and the aged from 2010 to 2021. The absolute number of GBTC cases continued to rise over the past decade in aged 55 years and older.
Keywords: Gallbladder and biliary tract cancer, Global Burden of DiseasesGBD, incidenceincident, death, Disability-adjusted life years, percentage change DALYs, aged 55 years and older
Received: 16 Jan 2025; Accepted: 04 Jun 2025.
Copyright: © 2025 Ouyang, Li, Li, Li, Zhao, Gan, Wu, Luo, Liang, 李, Pan and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Guoqing Ouyang, Liuzhou Key Laboratory of Liver Cancer Research, Liuzhou People’s Hospital, Liuzhou, Guangxi, China
Jianqing Yang, Liuzhou People's Hospital, Liuzhou, Guangxi Zhuang Region, China
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