SYSTEMATIC REVIEW article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1563604
This article is part of the Research TopicBridging knowledge to action in vitamin D supplementationView all 5 articles
The Effects of Magnesium and Vitamin D/E Co-Supplementation on Inflammation Markers and Lipid Metabolism of Obese/Overweight Population: A Systematic Review and Meta-analysis
Provisionally accepted
- 1The Second Clinical College of China Medical University, Shengyang, China
- 2Department of Pathology,The Shengjing Hospital of China Medical University, Shenyang, China
- 3Department of Laboratory Medicine,The Shengjing Hospital of China Medical University, Shenyang, China
- 4Department of Rehabilitation ,Milian Community Health Service Center,Huang Gu District, Shengyang, China
- 5Department of Ophthalmology, The Fourth People's Hospital of Shenyang, Shenyang, China
- 6Department of Orthopedics The Shengjing Hospital of China Medical University, Shenyang, China
- 7Department of Orthopedics, Shenging Hospital of China Medical University, Shenyang, China
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Background: Inflammatory reactions can induce or facilitate the occurrence and development of various diseases in the human body. It is crucial to regulate and actively control inflammatory factors to maintain the health of an individual. Vitamins D and E and magnesium ions may potentially inhibit inflammatory responses.Abnormal lipid metabolism is known to affect people's health and lead to serious diseases. Magnesium and vitamin E are also known to possess anti-lipidemic properties. It is worth noting that the prevalence and disease burden of some diseases are related to overweight and obesity. This systematic review and meta-analysis assesses the impact of magnesium and vitamin D or vitamin E co-supplementation on inflammation and lipid metabolism markers of obese/overweight population in randomized controlled trials (RCTs).Methods: A comprehensive search was conducted across PubMed, Web of Science, Embase and Cochrane databases until January 2024 to investigate the impact of simultaneous supplementation of magnesium and vitamin D/E. In both intervention and control groups, the research analyzed the pooled mean difference (MD) and the associated 95% confidence interval (CI) of marker levels of inflammation and lipid metabolism.Results: Meta-analysis of nine RCTs (total of 509 individuals) showed that magnesium and vitamin D significantly elevated the levels of 25(OH)D (MD:13.37, 95%CI: 0.45, 26.29, p=0.04) and magnesium (MD: 0.21, 95% CI: 0.16, 0.27, p < 0.00001). Co-supplementation of magnesium and vitamin D/E lowered levels of serum hypersensitivity C-reactive protein (hs-CRP) (MD:-1.19, 95%CI:-1.95, -0.42, p=0.002). In subgroup analysis, serum levels of hs-CRP was notably reduced in individuals receiving magnesium and vitamin D supplementation (MD=-0.66,95%CI:-1.17, -0.14, p=0.01). However, no significant differences were observed between magnesium and vitamin E supplementation 2.43, p=0.25).The combination of magnesium and vitamin D significantly reduced tumor necrosis factor-α (TNF-α) levels (MD:-0.87, 95%CI:-1.62, -0.11, p=0.02). In contrast, the serum levels of interleukin-6 (IL-6) showed a non-significant decrease (MD: -0.09, 95%CI: -0.33, 0.15, p = 0.46), and did not significantly affect lipid metabolism according to levels of parameters such as serum triglyceride (MD = 1.84, 95% CI:
Keywords: Magnesium, Vitamin D, Vitamin E, Inflammation, Meta - analysis
Received: 20 Jan 2025; Accepted: 25 Jul 2025.
Copyright: © 2025 Deng, Liu, Miao, Wang, Wang, Liu and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Liyu Yang, Department of Orthopedics, Shenging Hospital of China Medical University, Shenyang, China
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