SYSTEMATIC REVIEW article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1566422
This article is part of the Research TopicImmunomodulation by Vitamins: Mechanistic insights and clinical translationView all articles
Effects of Different Vitamins on Individuals with Septic Shock: a Bayesian NMA of RCTs
Provisionally accepted
jinjin tianLing LongDandan LiYahan LiangGuinan SunWenjing SongXizi Yue
Limin Shen
Heling Zhao
Shan Ren*- Hebei General Hospital, Shijiazhuang, China
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Objective: To compare the effects of different vitamins on patients with septic shock through Bayesian network meta-analysis.Methods: Randomized controlled trials on vitamins for septic shock patients were retrieved from PubMed, Embase, Cochrane Library, Web of Science, etc. The retrieval time was set from the mechanical ventilation time, VC, VD, VCVB, and HYDVCVB showed no statistically significant differences compared to the control group. Regarding the SOFA score after 24 hours, VDP was superior to the control group [MD=2.98, 95%CI (0.27, 5.62)], as well as HYDVCVB [MD=3.32, 95%CI (0.59, 6.04)], VB [MD=2.96, 95%CI (0.18, 5.67)], VC [MD=2.91, 95%CI (0.17, 5.57)], VCVB [MD=3.18, 95%CI (0.31, 5.9)], and VD [MD=2.91, 95%CI (0.05, 5.71)], with statistically significant differences. In terms of total hospital stay, VD was superior to the control group [MD=7.61, 95%CI (2.59, 12.63)], as well as HYDVCVB [MD=7.71, 95%CI (2.55, 12.9)], VB [MD=7.6, 95%CI (0.84, 14.39)], VC [MD=9.93, 95%CI (3.9, 15.92)], and VCVB [MD=8.1, 95%CI(1.79, 14.41)], with statistically significant differences. Regarding 28-day mortality, VB, VC, VD, VDP, VCVB, HYDVCVB showed no statistically significant differences compared to the control group.In patients with septic shock, the use of VD shows certain advantages in reducing ICU length of stay and total hospital length of stay. Moreover, its combination with probiotics may help reduce the SOFA scores after 24 hours. However, these interventions have not significantly impacted 28-day mortality or mechanical ventilation time.
Keywords: Vitamins, septic shock, Network meta-analysis, Vitamin D, Shock
Received: 24 Jan 2025; Accepted: 25 Jul 2025.
Copyright: © 2025 tian, Long, Li, Liang, Sun, Song, Yue, Shen, Zhao and Ren. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shan Ren, Hebei General Hospital, Shijiazhuang, China
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