ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutritional Epidemiology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1570740
This article is part of the Research TopicHolistic Approaches to Understanding Obesity and Metabolic Diseases in Urban EnvironmentsView all 11 articles
Abdominal obesity and osteoarthritis risk: evaluating the association of lipid accumulation product, body roundness index, and waist triglyceride index with osteoarthritis in U.S. Adults
Provisionally accepted
- 1Clinical School of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China
- 2Huangpu Traditional Chinese Medicine Hospital, Guangzhou, China
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Objective: This study explored the associations between Lipid Accumulation Product (LAP), Body Roundness Index (BRI), and Waist Triglyceride Index (WTI) and osteoarthritis (OA) in U.S. adults, using data from NHANES 2015-2018.This cross-sectional analysis included 3,611 participants aged ≥20 years.Using survey-weighted procedures, multivariable logistic regression assessed associations between anthropometric indices and OA. Smooth curve fitting evaluated non-linear relationships and threshold effects. Segmented linear regression was applied to identify potential inflection points. Subgroup analyses explored demographic and health-related variations, while ROC curves assessed the discriminative capacity of these anthropometric indices.Results: Among participants, 517 (14.31%) had OA. All indices showed positive associations with OA after adjustment: LAP (OR:1.19, CI:1.13-1.25), BRI (OR:1.02, CI:1.01-1.02), and WTI (OR:3.72, CI:2.25-6.16). LAP significantly increased OA risk below 131.16 (OR:1.02, p<0.001) but not above. BRI demonstrated a linear relationship with OA without significant threshold effects (p=0.190). WTI demonstrated dramatically increased risk above 8.72 (OR:74.40) versus below (OR:4.70). Significant interactions were observed for gender with BRI (p=0.0145) and hyperlipidemia with LAP (p=0.0024). Stronger associations appeared in participants with lower education, non-smokers (for BRI), and those with hypertension (for WTI). BRI showed higher diagnostic accuracy (AUC:0.6588).OA prevalence in U.S. adults, with distinct threshold effects for LAP and WTI. These indices, particularly BRI, may serve as valuable screening tools for OA risk assessment in clinical practice.
Keywords: Osteoarthritis, Lipid accumulation product, Body roundness index, Waist triglyceride index, abdominal obesity, visceral fat
Received: 04 Feb 2025; Accepted: 28 May 2025.
Copyright: © 2025 Li, Zhang, Pan, He and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Chunlong Liu, Clinical School of Acupuncture, Moxibustion and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou, China
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