ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1570771
This article is part of the Research TopicMaternal Metabolic Health: From Preconception to PostpartumView all 8 articles
ZJU index as a predictive biomarker of gestational diabetes mellitus: a prospective cohort analysis
Provisionally accepted
- 1Changchun University of Chinese Medicine, Changchun, Jilin Province, China
- 2The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, China
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The ZJU index, incorporating fasting plasma glucose (FPG), lipid profiles, liver enzymes, and body mass index (BMI), serves as a multidimensional tool for assessing metabolic dysregulation. This prospective investigation examined first-trimester ZJU index associations with both gestational diabetes mellitus (GDM) risk and nonalcoholic fatty liver disease (NAFLD) during pregnancy, while simultaneously evaluating the relationships between lipid profiles, liver enzymes, and GDM development.We conducted analyses using multivariable logistic regression and restricted cubic splines (RCS) to assess associations of the ZJU index, liver enzymes, and blood lipids with GDM, as well as the association between the ZJU index and NAFLD. Subgroup analyses were conducted to evaluate the correlation between the ZJU index (stratified by age and reproductive history) and GDM. The receiver operating characteristic (ROC) curve assessed the ZJU index's predictive power. The robustness of the findings was verified via sensitivity analyses.In the multivariable regression model, the ZJU index showed a significant positive association with GDM, after adjusting for confounders [OR = 1.24, 95% CI (1.13, 1.37)]. The RCS analysis revealed a linear dose-response relationship between the ZJU index and GDM. The area under the curve (AUC) for the ZJU index was 0.802, indicating a high predictive ability for GDM. Associations between the ZJU index and GDM remained consistent across subgroups and sensitivity analyses.The ZJU index is closely associated with GDM prevalence.
Keywords: ZJU1, Gestational diabetes mellitus2, liver enzyme3, early pregnancy, Lipid index
Received: 04 Feb 2025; Accepted: 27 May 2025.
Copyright: © 2025 Xu, Li, Wang, Xu and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Changhui Li, The Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, China
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