ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition, Psychology and Brain Health
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1576724
Association between neutrophil percentage-to-albumin ratio and Parkinson's disease amongst adults in the US
Provisionally accepted
- 1Suining Central Hospital, Suining, China
- 2Guilin Women’s and Children’s Hospital, Guilin，Guangxi Zhuang Autonomous Region, China
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Inflammation is an important factor in Parkinson's disease (PD). Researchers are exploring the integration of multiple biomarkers, including inflammatory and noninflammatory markers, to enhance predictive value. Neutrophil-to-albumin ratio (NPAR), a novel inflammatory biomarker, offers economic efficiency and accessibility. However, the association between NPAR and PD remains to be elucidated.We conducted a cross-sectional study involving participants aged 40 years and above from the National Health and Nutrition Examination Survey (NHANES) database, spanning the years 1999 to 2018.NPAR was calculated as neutrophil percentage (in total white blood cell (WBC) count) (%) × 100/albumin (g/dL). A multivariable logistic regression model was employed to examine the independent association between NPAR and PD while adjusting for demographic factors; educational level; income-to-poverty ratio; smoking status; alcohol consumption; body mass index (BMI); physical activity; and history of hypertension, diabetes, hyperlipidaemia and cardiovascular diseases. Additionally, subgroup analyses were conducted to investigate whether the effect of NPAR varied across different demographic subgroups.The NPAR score demonstrates a significant positive correlation with PD. When examined as a categorical variable, individuals in the highest tertiles of NPAR show a 65% increased prevalence of PD compared with those in the lowest tertiles (odds ratio [OR] 1.65 [95% confidence interval {CI} 1.16, 2.34]).Moreover, weighted restricted cubic spline and threshold effect analyses confirmed a positive association between NPAR and PD, identifying a threshold and saturation effect inflection point at 9.82. An elevated likelihood of PD development exists beyond the NPAR level of 9.82 (OR 1.12 [95% CI 1.06, 1.19]). Additionally, subgroup analyses and interaction tests reveal that BMI and hypertension significantly influence the relationship between NPAR and PD (P < 0.05).Our study revealed a posi PAR levels and PD, indicating that high NPAR levels are associated with an increased likelihood of developing PD.
Keywords: Inflammation, Neutrophil percentage-to-albumin ratio, Parkinson's disease, Prevalence, National Health and Nutrition Examination Survey
Received: 14 Feb 2025; Accepted: 17 Jul 2025.
Copyright: © 2025 Ke, Tang, Li, Xing, Zhao and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Lei Zhao, Suining Central Hospital, Suining, China
Sili Jiang, Suining Central Hospital, Suining, China
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