ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1578954
Dietary Inflammatory Index Mediation Lifestyle Patterns and Depression among Women with Osteopenia or Osteoporosis
Provisionally accepted
- 1Tianjin Medical University General Hospital, Tianjin, China
- 2Tianjin University, Tianjin, China
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Objective: Lifestyle factors play a critical role in osteoporosis management and are closely linked to the development and progression of comorbid depression. This study examines lifestyle patterns and their association with depression in individuals with osteopenia or osteoporosis, while assessing the mediating role of the Dietary Inflammatory Index (DII). Methods: Data from the National Health and Nutrition Examination Survey (NHANES) 2009-2020 were analyzed, with latent class analysis (LCA) applied to 3,384 adults based on lifestyle behaviors. A generalized linear model (GLM) evaluated the effects of lifestyle patterns on depression, and mediation analysis tested associations between these patterns, DII, and Patient Health Questionnaire-9(PHQ-9) scores. Results: LCA identified three lifestyle groups: healthy but inactive (34.16%), unhealthy (8.78%), and sedentary (57.06%). The unhealthy (OR = 2.848, 95% CI = 1.550-5.234, P = 0.001) and sedentary (OR = 1.600, 95% CI = 1.127-2.271, P = 0.009) groups were associated with higher depression risk in women. DII partially mediated the relationships between unhealthy lifestyle and PHQ-9 (effect coefficient = 0.095, 95% CI: 0.056-0.135) and between sedentary lifestyle and PHQ-9 (effect coefficient = 0.059, 95% CI: 0.017-0.115). Conclusions: These findings suggest that lifestyle patterns significantly influence depression in women with osteopenia or osteoporosis, with DII serving as a partial mediator.
Keywords: dietary inflammation index (DII), Depression, Lifestyle patterns, osteopenia, Osteoporosis, NHANES
Received: 18 Feb 2025; Accepted: 12 Jun 2025.
Copyright: © 2025 Wang, Fan, Tang, Guo, Li and Dai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yin Li, Tianjin University, Tianjin, China
Chenlin Dai, Tianjin Medical University General Hospital, Tianjin, 300052, China
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