ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Microbes
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1580122
This article is part of the Research TopicDeciphering Microbial Metabolites: Their Impact on Gastrointestinal and Metabolic HealthView all 8 articles
The Relationship Between Dietary Index for Gut Microbiota and Hyperuricemia: A Cross-Sectional Study Using NHANES Data
Provisionally accepted
- 1The First People’s Hospital of Guiyang, Guiyang, China
- 2Department of Rheumatology, The Second Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, China
- 3The Second Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, China
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Background: Hyperuricemia (HUA) is a common metabolic disorder, yet the impact of diet and gut microbiota on uric acid metabolism remains insufficiently understood. This study aims to investigate the relationship between the dietary index for gut microbiota (DI-GM) and HUA using data from the National Health and Nutrition Examination Survey (NHANES). Methods: This study employed NHANES data gathered from 2007 to 2020, encompassing 25,899 adults aged 18 years and older. The DI-GM, which spans from 0 to 14, was calculated based on dietary recall information. The diagnosis of HUA was established through laboratory findings. To examine the relationship between DI-GM and HUA, multivariable logistic regression was utilized, accounting for pertinent confounding variables. Results: Upon adjusting for possible confounding variables, an elevated DI-GM score demonstrated a notable correlation with a reduced likelihood of HUA (odds ratio [OR] = 0.968, 95% confidence interval [CI] = 0.949-0.987, p = 0.005). Subjects exhibiting a DI-GM score of ≥6 demonstrated a markedly reduced risk of HUA in contrast to those scoring between 0 and 3 (OR = 0.897, 95% CI = 0.821-0.980, p = 0.016). Conclusion: A higher DI-GM score is inversely related to the risk of HUA.
Keywords: Hyperuricemia, Dietary Index for Gut Microbiota, Diet index, Nutritional epidemiology, NHANES
Received: 20 Feb 2025; Accepted: 07 May 2025.
Copyright: © 2025 Cai, Zhang, Lan, Jin, Liu, Jiang and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xin Cai, The First People’s Hospital of Guiyang, Guiyang, China
Qingwan Yang, The Second Affiliated Hospital, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou Province, China
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