ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1583598
Association between Insulin Resistance-Related Lipid Indices and Arthritis: A US Cross-Sectional Study
Provisionally accepted
- 1Shandong University of Traditional Chinese Medicine, Jinan, China
- 2Sun Yat-sen University, Guangzhou, Guangdong Province, China
- 3Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China
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Objectives:Arthritis is a degenerative disease that causes a huge social burden. Lipid-related molecules participate in the inflammatory response process of arthritis and are closely related to the pathological process of arthritis. Lipid-related indicators are easily available and have great potential in predicting arthritis. This study used cross-sectional data to explore lipid-related indicators and arthritis risk. Methods:18,683 participants were involved in this study, selected from the NHANES database covering the period from 2001 to 2018.The study utilized multivariate regression models to examine the association between various lipid-related parameters (including the TyG index, TyG-WC index, TyG-WHtR index, TyG-BMI index, HOMA-IR index, VAI index, and LAP index) and arthritis.Results:After taking into account and appropriately addressing potential confounding variables and factors, all seven lipid-related indicators were positively associated with arthritis risk, and there was a significant difference in the highest quartile of seven lipid-related indicators compared with the lowest quartile (p < 0.001).Among them, the area under the ROC curve (AUC) of TyG-WC, TyG-WHtR, TyG-BMI, and LAP was greater than 0.6, indicating they had modest accuracy in predicting arthritis.Logistic regression analysis showed that the best Cut-off values for predicting arthritis for these indicators were as follows:
Keywords: TyG, Insulin Resistance, Arthritis, Cross-sectional study, NHANES
Received: 26 Feb 2025; Accepted: 12 Jun 2025.
Copyright: © 2025 Wu, Teng, Wang and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Honghao Xu, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, 250011, Shandong Province, China
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