REVIEW article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1583889
This article is part of the Research TopicNutrition in Pancreatic Diseases: The Role of Nutritional Status and Nutrition Therapy in the Management of Pancreatitis and Pancreatic CancerView all 6 articles
Precision Nutrition Management in Hyperlipidemia-Associated Acute Pancreatitis: Mechanistic Insights and Personalized Therapeutic Approaches
Provisionally accepted
- 1Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
- 2First Affiliated Hospital, Dalian Medical University, Dalian, China
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Hyperlipidemia-associated acute pancreatitis (HLAP), an acute inflammatory disorder triggered by dyslipidemia, has witnessed a rising global incidence with significant health implications. The pathogenesis of HLAP involves complex interactions among lipid metabolism dysregulation, inflammatory cascades, and oxidative stress. Conventional therapeutic approaches, while providing partial symptomatic relief, exhibit limitations in addressing individual variability. Precision nutrition management emerges as a novel paradigm integrating multi-omics profiling (genomic, metabolomic) and clinical parameters to develop personalized intervention strategies. This comprehensive review analyzes the pathophysiological mechanisms linking lipid dyshomeostasis to HLAP progression, systematically evaluates the scientific foundation for precision nutrition interventions, and identifies key gaps in current implementation strategies. Furthermore, we examine current research limitations and outline future avenues for enhancing therapeutic efficacy via personalized nutritional interventions.
Keywords: Hyperlipidemia, acute pancreatitis, Precision nutrition, Clinical Nutrition, Mechanism, Multi-omics integration, personalized medicine
Received: 26 Feb 2025; Accepted: 09 Jun 2025.
Copyright: © 2025 Ma, Wan, Liu, Hu, Ma and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yunhai Gao, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China
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