SYSTEMATIC REVIEW article
Front. Nutr.
Sec. Nutrition and Microbes
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1587348
This article is part of the Research TopicStrain-Specific Probiotics: Enhancing Children's Health Through Targeted Clinical ResearchView all 15 articles
Probiotics Supplements for the Prevention of Atopic Dermatitis in Children: An Umbrella Review
Provisionally accepted
- 1Department of dermatology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China
- 2School of Medicine and Life Science, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China
- 3Institute of Dermatology and Venereology, Sichuan Provincial People’s Hospital,, Chengdu, China
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Previous meta-analyses of multiple studies have suggested that probiotics supplementation plays a role in reducing the risk of atopic dermatitis (AD). However, the conclusions of these studies remain controversial. We conducted an umbrella review of meta-analyses to comprehensively analyze and evaluate the evidence regarding the association between probiotics and AD. We searched PubMed, Web of Science, Embase, Spous, and Cochrane Library databases for meta-analyses and systematic reviews up to October 2024. Our selection criteria encompassed meta-analyses of cohort studies, case-control studies, and randomized controlled clinical trials investigating the associations between probiotics and the risk of AD. We also assessed the levels of evidence for these associations using the AMSTAR 2 criteria. A total of 32 eligible articles, including 126 meta-analyses, were included for qualitative synthesis in this umbrella review. The results indicate that probiotics supplementation is associated with a reduced risk of AD. The subgroup analysis indicates that supplementation with Lactobacillus spp., single-strain, and multi-strain probiotics is associated with a reduced risk of AD, with multi-strain formulations potentially demonstrating more pronounced effects. Furthermore, both combined prenatal and postnatal supplementation, as well as postnatal supplementation alone, contribute to a reduction in AD risk, highlighting the potential significance of early-life probiotics intervention in the prevention of AD. Future research should focus on well-designed randomized controlled trials that account for potential sources of bias in order to provide evidence-based public health recommendations.
Keywords: Probiotics, atopic dermatitis, Children, Umbrella, Meta-analysis, prevention
Received: 04 Mar 2025; Accepted: 20 Jun 2025.
Copyright: © 2025 Zhong, Su, Zhou and Wan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Huiying Wan, Institute of Dermatology and Venereology, Sichuan Provincial People’s Hospital,, Chengdu, China
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