ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1589062
Exploring a Link between the Association of Vitamin B12 Deficiency and Dental Caries Health in Older Adults
Provisionally accepted
- College of Dental Medicine, Roseman University of Health Sciences, South Jordan, Utah, United States
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Background: Vitamin B12 plays a crucial role in overall health, yet its impact on oral dental health, particularly dental caries, remains underexplored. Older adults are at an increased risk of vitamin B12 deficiency and dental disease, but the relationship between these two factors is not well understood. This study examines the association between serum vitamin B12 levels and dental caries health in older adults using data from the NHANES 2011-2014 cycles.Methods: A cross-sectional analysis was conducted using NHANES data from 1,907 participants aged 65 and older. Serum vitamin B12 levels were categorized as normal (>221 pmol/L), marginal (148-221 pmol/L), and deficient (<148 pmol/L). Dental caries experience status was assessed using the Decayed, Missing, and Filled Teeth (DMFT) index and untreated caries based on NHANES oral dental health examinations. Logistic and Poisson regression models evaluated associations between vitamin B12 levels, untreated caries, and DMFT scores, adjusting for age, sex, race/ethnicity, education, and income.Results: Lower vitamin B12 levels were significantly associated with higher DMFT scores (p < 0.05). Participants with marginal and deficient vitamin B12 levels exhibited increased DMFT scores compared to those with normal vitamin B12 levels, and these differences persisted after adjusting for demographic and socioeconomic factors. The findings suggest that inadequate vitamin B12 status may contribute to a greater cumulative burden of dental disease in older adults.. However, the association between vitamin B12 deficiency and untreated caries lost significance after adjusting for confounding variables. Although a higher prevalence of untreated caries was initially observed among individuals with vitamin B12 deficiency, this association was not statistically significant after adjusting for confounding variables. Conclusion: These findings suggest that vitamin B12 deficiency may contribute to a greater lifetime burden of dental disease in older adults. Further research is needed to explore causal mechanisms and assess whether vitamin B12 supplementation could be a preventive measure for maintaining oral dental health in aging populations.
Keywords: Vitamin B12, Dental Caries, older adults, NHANES, Oral Health, dental health
Received: 06 Mar 2025; Accepted: 03 Jun 2025.
Copyright: © 2025 Hung, Mohajeri, Marx, Ward and Lipsky. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Man Hung, College of Dental Medicine, Roseman University of Health Sciences, South Jordan, UT 84095, Utah, United States
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