CASE REPORT article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1590837
Reversible Chorea Arising from Severe Vitamin B12 Deficiency Due to Autoimmune Gastritis: A Comprehensive Case Study
Provisionally accepted
- 1Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu Province, China
- 2Xuzhou Medical University, Xuzhou, Jiangsu Province, China
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Cognitive impairment, ocular neuropathy, sensorimotor polyneuropathy, and subacute combined spinal cord degeneration can all result from a common illness called vitamin B12 insufficiency. With regard to extrapyramidal movement disorders, it is rare, frequently misdiagnosed, and underrecognized, which postpones timely treatment. A case study of a 66-year-old man with acute-onset and reversible choreoathetoid symptoms is presented in this publication. A significant vitamin B12 deficiency and an abnormal hypermetabolism in the basal ganglia region were detected by 18F-FDG PET/CT. Remarkably, the patient's dyskinesia disappeared as soon as vitamin B12 replacement therapy was administered. The patient's etiology was identified as a mix of vitamin B12 malabsorption and inadequate intake from autoimmune-related gastritis. In order to achieve the best potential therapeutic results, this case highlights the importance of timely and correct diagnosis, timely treatment of vitamin B12 deficiency based on its underlying etiology, and careful research of multiple etiologies.
Keywords: vitamin B12 deficiency, Chorea, Autoimmune gastritis, 18F-FDG PET/CT, Movement Disorders
Received: 12 Mar 2025; Accepted: 05 Aug 2025.
Copyright: © 2025 Yang, Geng, Chen, Zhou, Huang, Chen and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Weiwei Chen, Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu Province, China
Xia Zhang, Department of Neurology, Xuzhou Central Hospital, Xuzhou, Jiangsu Province, China
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