REVIEW article
Front. Nutr.
Sec. Nutritional Immunology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1594120
This article is part of the Research TopicHealth Effects of Natural Compounds from PlantView all 9 articles
cGAS-STING pathway as a promising target for digestive diseases: Insights from natural plant products
Provisionally accepted
- 1The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China
- 2Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China
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Digestive diseases remain a major challenge to public health systems globally. Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon gene (STING) play important roles in innate immunity as well as inflammatory responses. Dysregulation of the cGAS-STING pathway has been demonstrated to be an important pathogenetic mechanism in diverse gastrointestinal diseases. Therefore, targeting the cGAS-STING pathway is a potential therapeutic strategy for digestive diseases. Encouragingly, increasing studies have revealed that natural plant products are promising candidates for the treatment of digestive disorders. This review discussed the research progress of cGAS-STING pathway mediating common digestive diseases, including inflammatory bowel disease, liver disease, colorectal cancer, gastric cancer, esophageal cancer, pancreatitis, and pancreatic cancer. In addition, we systematically summarized recent advances in the treatment of gastrointestinal disorders with phytochemicals that target the cGAS-STING pathway.
Keywords: CGAS, STING, digestive diseases, Natural Products, Active ingredients
Received: 15 Mar 2025; Accepted: 10 Jun 2025.
Copyright: © 2025 Long, Mao, Zhu and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yin Xu, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, China
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