ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutritional Epidemiology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1594656
The Health Burden of Disease Attributable to Low Calcium Intake: A Comprehensive Analysis of Trends and Socioeconomic Impacts from 1990 to 2021
Provisionally accepted
Yanping Wang1
Meihui Tao1
Li Wang2Siyu Zhou3Weifeng Yang1Xi Zhao1Qinyu Feng1Mengfan Tang1
Wei Yan4*
Yu Fu1*- 1Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- 2Department of Emergency Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- 3Department of Gastrointestinal Surgery, the Affiliated Hospital, Southwest Medical University, Luzhou, China
- 4Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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Background: Calcium, a vital nutrient for the human body, is indispensable for keeping our bones strong and managing cell function. A diet low in calcium (DLC) is a key player in the formation of numerous health issues. This research delved into the most recent datasets acquired via the 2021 Global Burden of Disease (GBD) report to uncover the worldwide impact of DLC.Methods: Utilizing the GBD 2021 database, this research examined the association of DLC with disease burden, covering colorectal and prostate cancers. To quantify disease burden and track its temporal variations, key indicators were employed. These included deaths, disability-adjusted life years (DALYs), age-standardized mortality rate (ASMR), age-standardized DALY rate (ASDR), and the estimated annual percentage change (EAPC). The analysis broke down results by sex, age brackets, Socio-demographic Index (SDI) categories, and geographic regions. To examine potential links between disease burden and socioeconomic factors, Pearson's correlation method was applied. Furthermore, Bayesian age-period-cohort (BAPC) modeling was applied to forecast trends spanning 2022-2050.
Keywords: Global burden of disease, Human Development Index, socio-demographic index, diet low in calcium, Colon and rectum cancer, prostate cancer
Received: 18 Mar 2025; Accepted: 24 Jun 2025.
Copyright: © 2025 Wang, Tao, Wang, Zhou, Yang, Zhao, Feng, Tang, Yan and Fu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wei Yan, Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Yu Fu, Department of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.