MINI REVIEW article
Front. Nutr.
Sec. Nutrition, Psychology and Brain Health
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1595813
This article is part of the Research TopicBridging knowledge to action in vitamin D supplementationView all 3 articles
The Role of Vitamin D in Sleep Regulation: Mechanisms, Clinical Advances, and Future Directions
Provisionally accepted
- 1Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou Province, China
- 2Department of Neurology, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou, China, Zunyi Medical University, Zunyi, China
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Vitamin D, an essential neuroendocrine regulator, exhibits a significant dosedependent association with various sleep disorders according to epidemiological evidence, and plays a multifaceted and critical role in sleep regulation. This review summarizes the molecular mechanisms, clinical applications, and future directions of vitamin D in sleep regulation. Vitamin D may influence sleep through multiple molecular pathways, including modulation of neurotransmitter systems, maintenance of circadian rhythms, and neuroimmune regulation. Clinical trials have demonstrated that vitamin D supplementation significantly improves sleep quality, particularly in special populations such as the elderly and pregnant women. However, challenges persist in optimizing individualized treatment regimens, developing novel drug delivery systems, and evaluating longterm efficacy. The integration of multi-omics analyses and artificial intelligence offers innovative solutions to these challenges. Future research should focus on elucidating the precise molecular mechanisms of vitamin D in sleep regulation, refining personalized therapeutic strategies, and advancing innovative delivery systems to enhance the prevention and treatment of sleep disorders.
Keywords: Vitamin D, sleep regulation, vitamin D receptor, Sleep Disorders, single-cell sequencing
Received: 19 Mar 2025; Accepted: 14 May 2025.
Copyright: © 2025 Cai, Rui, Feng, Huang and Luo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Fei Feng, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou Province, China
Nanqu Huang, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou Province, China
Yong Luo, Department of Neurology, Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou, China, Zunyi Medical University, Zunyi, China
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