ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Microbes
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1596424
This article is part of the Research TopicXenobiotics, Gut Microbiota, and Chronic DiseaseView all 10 articles
Association of the dietary index for gut microbiota and Chronic Obstructive Pulmonary Disease: a cross-sectional study
Provisionally accepted
- Beijing Luhe Hospital, Capital Medical University, Beijing, China
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Background: Gut microbiota plays a vital role in maintaining human health. The dietary index for gut microbiota (DI-GM), which reflects the diversity of gut microbiota, has not yet been studied for chronic obstructive pulmonary disease (COPD).Methods: This cross-sectional study analyzed data from adult participants in the 1999-2018 National Health and Nutrition Examination Survey. COPD was identified based on self-reported data. The DI-GM was calculated using dietary recall data. Multivariable logistic regression models were employed to assess the association between DI-GM and COPD. To evaluate the robustness of the association, subgroup and sensitivity analyses were applied.Results: Increased DI-GM was associated with a decreased prevalence of COPD (OR=0.96; 95% CI, 0.92-0.99; P=0.016). Greater beneficial gut microbiota scores were inversely related to the prevalence of COPD (OR=0.95; 95% CI, 0.91-1.00; P=0.03). Both unweighted and multiple interpolated logistic regression analyses confirmed that the relationship remained consistent.Subgroup analyses further supported the robustness of the findings. Conclusion: A negative association was observed between DI-GM and the prevalence of COPD.(such as emphysema), which lead to chronic and often progressive airflow limitation(1). According to the Global Burden of Diseases, Injuries, and Risk Factors Study 2021, COPD is the fourth most common cause of death globally(2). The rising incidence and significant socioeconomic burden it imposes on societies have made it an escalating public health issue. Although there have been
Keywords: Dietary Index for Gut Microbiota, chronic obstructive pulmonary disease, NHANES, dietary, Gut Microbiota
Received: 19 Mar 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Ao, Huang, Zhen and Hu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ming Hu, Beijing Luhe Hospital, Capital Medical University, Beijing, China
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