ORIGINAL RESEARCH article
Front. Nutr.
Sec. Sport and Exercise Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1600038
This article is part of the Research TopicDiet and Exercise: Modulating Gut Microbiota for Enhanced Physiological FunctionView all 3 articles
The Impact of Physical Activity and Dietary Habits on Glycolipemic Metabolism and Inflammatory Markers in the Elderly: A Cross-Sectional Study
Provisionally accepted
- 1Physical Education College, Jiangxi Normal University, Nangchang, China
- 2Jinggangshan University, Ji'an, Jiangxi Province, China
- 3Beijing Normal University, Beijing, China
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Objective: Metabolic syndrome and chronic inflammation significantly impact the quality of life of the elderly. Physical activity and dietary habits are two of the most important modifiable aspects of lifestyle. Thus, this study investigated the effects of physical activity and dietary habits on relevant biomarkers in the elderly.Methods: A total of 2349 elderly participants aged 60 -75 were recruited. Physical activity was measured using the International Physical Activity Questionnaire (IPAQ) short form. Dietary habits and intakes were assessed via the Dietary Quality Questionnaire (DQQ) and 24 -hour recalls. Fasting blood samples were analyzed for glycolipid metabolism and inflammatory markers, such as C -reactive protein (CRP) and interleukin -6 (IL -6).Results:There was a close association between physical activity and diet. Moderateintensity physical activity (MPA) was positively associated with the intake of dark green leafy vegetables (β = 0.174) and negatively associated with the intake of unprocessed red meat (β = -0.112) and deep -fried foods (β = -0.117). Both physical activity and diet affected biomarkers. Vigorous physical activity was positively correlated with high -density lipoprotein cholesterol (r = 0.144), while MPA was negatively correlated with blood glucose (r = -0.127) and CRP (r = -0.129). The percentage of protein intake was positively correlated with triglycerides (r = 0.118).Mediation analysis demonstrated the combined effects of physical activity and diet. The results showed that MPA significantly and negatively affected CRP levels, with the intake of dark green leafy vegetables mediating this relationship (P < 0.05). MPA also significantly and negatively affected blood glucose levels, with vitamin B12 intake mediating this relationship (P < 0.05).The study indicates that physical activity and diet interact with each other and jointly affect blood glucose and inflammation in the elderly. Diet mediates the effect of physical activity on biomarkers. Further longitudinal studies are needed to verify the findings of this study.
Keywords: physical activity, Vitamin B, Inflammatory markers, Elderly, Mediation analysis
Received: 25 Mar 2025; Accepted: 03 Sep 2025.
Copyright: © 2025 Zhang, Zou and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jiangang Chen, Beijing Normal University, Beijing, China
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