ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutritional Epidemiology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1610288
The Association Between Waist-to-Height Index and Prostate Cancer Risk: Evidence from the NHANES Study
Provisionally accepted
- Department of Urology, Shishi City General Hospital, Quanzhou, China
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Prostate cancer (PCa) is associated with obesity, especially visceral fat. WWI may reflect the distribution of body fat more accurately. However, it is unclear whether WWI is associated with the risk of developing PCa.The associations between WWI and PCa risk were analyzed through multiple regression. The association between WWI and prostate cancer was analyzed in subgroups using stratified factors, with interaction tests performed to evaluate the stability of this association across subgroups. In addition, restricted cubic sample plots and threshold effects were examined to further explore the nonlinear association between WWI and prostate cancer. Finally, subject work characteristics (ROC) curves were used to evaluate the accuracy of different obesity indicators in predicting PCa.Multiple regression analyses revealed that those individuals with a higher WWI index had a higher prevalence of prostate cancer, while subgroup analyses and interaction tests showed that the correlation between WWI and the prevalence of PCa differed across age groups (interaction p < 0.05). The ROC curves showed that the predictive power of WWI for the prevalence of PCa was superior to that of traditional indicators of obesity (both p < 0.05).There was a positive and significant association between PCa risk and WWI, especially in male participants aged <60 years. Further comprehensive studies are required to confirm our findings.
Keywords: WWI, abdominal obesity, visceral fat, PCA, NHANES, ROC Curve
Received: 11 Apr 2025; Accepted: 20 May 2025.
Copyright: © 2025 Gao, Cai, Zhang, Lin and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiantong Cai, Department of Urology, Shishi City General Hospital, Quanzhou, China
Shaopeng Li, Department of Urology, Shishi City General Hospital, Quanzhou, China
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