ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutritional Epidemiology
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1610474
Changes in Insulin Resistance and Other Metabolic Parameters During Home Quarantine Amid the COVID-19 Pandemic Among the General Population
Provisionally accepted
Yuting Zhang1
Wenting Chen2Lijian Ran2Jing Wang2Jie Xia2Shilian Li2Qing Mao2*
Zongtao Chen2*
Huimin Liu2*- 1Department of health Management, Southwest Hospital, Third Military Medical University, Chongqing, China
- 2southwest hospital, third military medical university, Chongqing, China
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Background: This study aims to investigate the impact of home quarantine on insulin resistance and other metabolic parameters in general populations through the changes in metabolic profile, especially Triglyceride/Glucose (TyG). Methods: This study included participants who underwent two health checkups at the Health Management Center of the First Affiliated Hospital of the Army Medical University, before and after home quarantine, between December 2021 and February 2023. The home quarantine policy in the Chongqing area was executed between August 2022 and December 2022. Triglyceride/Glucose (TyG), TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC) were calculated. Results: A total of 19,957 cases were screened, and 2473 participants (mean age: 39.35±10.36 years, 69.8% female) were included for the final analysis. Compared to before home quarantine, the TyG (6.80±0.58 vs. 6.83±0.58, P < 0.001), TyG-BMI (158.30±31.92 vs. 159.48±31.73, P < 0.001), and TyG-WC (533.53±103.15 vs. 535.78±103.65, P = 0.039) increased significantly after the home quarantine. Besides, glucose, lymphocyte, and platelet decreased significantly while BMI, systolic blood pressure, diastolic blood pressure, pulse, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein, uric acid, red blood cell, and monocyte also increased significantly after home quarantine (all P < 0.05). Conclusion: Home quarantine might pose a potential negative impact on insulin resistance risk, indicating that insulin resistance and other metabolic health parameters during the home quarantine period should be monitored regularly.
Keywords: Home quarantine, triglyceride, Glucose, Body Mass Index, Metabolic biomarkers
Received: 25 Apr 2025; Accepted: 22 Sep 2025.
Copyright: © 2025 Zhang, Chen, Ran, Wang, Xia, Li, Mao, Chen and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Qing Mao, qingmao@tmmu.edu.cn
Zongtao Chen, chenzongtao@tmmu.edu.cn
Huimin Liu, liuhuimin@tmmu.edu.cn
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