ORIGINAL RESEARCH article

Front. Nutr.

Sec. Nutritional Epidemiology

Volume 12 - 2025 | doi: 10.3389/fnut.2025.1611227

Global Burden and Trends of High BMI-Attributable Chronic Kidney Disease: A Comprehensive Analysis from 1990 to 2021 and Projections to 2035

Provisionally accepted
Huifang TanHuifang Tan1Zhifu LiuZhifu Liu2Yongjie ZhangYongjie Zhang1Kehao YangKehao Yang2Yiming ZengYiming Zeng2Guoli LiGuoli Li1Zhen XiaoZhen Xiao1Yuanwei LiYuanwei Li2*Yinyin ChenYinyin Chen1*
  • 1Department of Nephrology, Hunan Provincial People’s Hospital, changsha, China
  • 2Department of Urology, Hunan Provincial People's Hospital, Changsha, Hunan Province, China

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Background: High body mass index (BMI) is a major modifiable risk factor for chronic kidney disease (CKD), significantly contributing to its global burden. This study aimed to systematically evaluate the global burden of CKD attributable to high BMI from 1990 to 2021, identify demographic and regional variations, evaluate contributing risk factors, and project future trends through 2035.: The population-based analysis utilized data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021, encompassing 204 countries and territories across 21 GBD regions. Age-standardized mortality rate (ASMR) and age-standardized disability-adjusted life years rate (ASDR) were assessed using percentage change (PC) and estimated annual percentage change (EAPC).Decomposition analysis quantified drivers of mortality and DALYs changes, while Bayesian age-period-cohort models projected future trends.

Keywords: CKD, High BMI, Obesity, Global burden, Demographic and Regional Disparities, Trend projections

Received: 14 Apr 2025; Accepted: 23 Jun 2025.

Copyright: © 2025 Tan, Liu, Zhang, Yang, Zeng, Li, Xiao, Li and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Yuanwei Li, Department of Urology, Hunan Provincial People's Hospital, Changsha, Hunan Province, China
Yinyin Chen, Department of Nephrology, Hunan Provincial People’s Hospital, changsha, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material