Precision Nutrition in Sports Science: An Opinion on Omics-Based Personalization and Athletic Outcomes

Mirza Hapsari Penggalih¹Yosef Stefan Sutanto²Nurpudji Astuti Taslim³Rony Abdi Syahputra^4*Hardinsyah Hardinsyah⁵Raymond Rubianto Tjandrawinata⁶Fahrul Nurkolis^7,8,9

• ¹Gadjah Mada University, Yogyakarta, Special Region of Yogyakarta, Indonesia
• ²Sam Ratulangi University, Manado, North Sulawesi, Indonesia
• ³Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
• ⁴Faculty of Pharmacy, University of North Sumatra, Medan, North Sumatra, Indonesia
• ⁵IPB University, Bogor, West Java, Indonesia
• ⁶Center for Pharmaceutical and Nutraceutical Research and Policy, Atma Jaya Catholic University of Indonesia, Jakarta, Jakarta, Indonesia
• ⁷Medical Research Center of Indonesia, Surabaya, Indonesia
• ⁸State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga Yogyakarta), Yogyakarta, West Java, Indonesia
• ⁹Faculty of Medicine, Airlangga University, Surabaya, East Java, Indonesia

Precision nutrition has emerged as a rapidly evolving interdisciplinary field within sports science, presenting an innovative approach to tailoring nutritional strategies for optimizing athletic performance (1)(2)(3). By harnessing omics technologies such as nutrigenomics, metabolomics, proteomics, and transcriptomics, precision nutrition delves into the molecular and metabolic nuances of athletes (4). These advancements pave the way for individualized nutritional interventions that consider genetic, biochemical, and environmental variations, moving beyond traditional, generalized dietary recommendations. In a landscape increasingly shaped by data-driven approaches, the application of omics-based precision nutrition has the potential to refine strategies for training adaptation, recovery, injury prevention, and performance enhancement (5).This review explores the intersection of precision nutrition and sports science, highlighting the role of omics technologies in crafting personalized dietary solutions for athletes. By addressing three key research questions, the review synthesizes and critically evaluates existing literature: How can omics technologies be utilized to optimize personalized nutrition strategies for athletic populations? What evidence supports the effectiveness of such interventions in enhancing performance, recovery, and injury prevention? And what challenges and opportunities are encountered when translating omicsbased findings into practical applications within sports settings? Addressing these questions provides a foundation for understanding how molecular-level insights can be applied to achieve measurable benefits for athletes.The methodology employed in this review includes a comprehensive analysis of existing peerreviewed literature, spanning studies on genomics, proteomics, metabolomics, and transcriptomics, as well as systematic reviews and clinical trials (6). By integrating findings from diverse studies, the paper adopts a narrative approach to present a cohesive understanding of omics-based precision nutrition. Key analytical methods include critical evaluation, comparative analysis of technological applications, and reflection on methodological advancements and limitations. This approach ensures a balanced discussion that underscores areas of progress while acknowledging remaining challenges in the field.Current research demonstrates the promising potential of omics technologies to enhance sports nutrition. For example, metabolomics has advanced the understanding of metabolic pathways such as fatty acid oxidation and glycolysis in exercise physiology, while nutrigenomics has identified genetic markers associated with athletic traits such as endurance and injury susceptibility (7,8). Proteomics has further enabled insights into protein expression changes during recovery and adaptation (9). However, challenges persist in translating these findings into scalable and actionable interventions, with limitations stemming from methodological inconsistencies, ethical considerations, and the complexity of integrating multi-omics data.The structure of this paper is designed to provide a thorough exploration of the topic. Following The heritability of elite athletic performance, with estimates attributing up to 70% of variance in athlete status to genetic factors, emphasizes the crucial role of genomics in understanding athletic potential (16). This high degree of genetic influence supports the use of genomic screening for early talent identification and strategic athlete development. However, heritability studies often do not account for environmental influences, such as training and nutrition, which interact with genetic predispositions to shape performance outcomes. The complexity of these gene-environment interactions necessitates more integrative research approaches to contextualize heritability findings (17).Genome-wide association studies (GWAS) have significantly contributed to our understanding of the genetic architecture of athletic traits by identifying hundreds of potential performance-related single nucleotide polymorphisms (SNPs) (18)(19)(20). However, these studies often face reproducibility issues due to small sample sizes, ethnic homogeneity, and confounding variables. Initiatives like the Athlome Project Consortium underscore the importance of large and diverse sample sizes to address these challenges. Despite technological advancements, the inability to consistently identify significant genetic variants highlights a limitation of current GWAS methodologies (21)(22)(23). This shortcoming points to the need for innovative study designs that go beyond statistical associations to elucidate causal relationships underlying athletic traits (17,24).The transition from candidate gene approaches to hypothesis-free GWAS methodologies has marked a significant evolution in sports genomics. By reducing bias and expanding the scope of inquiry, this shift holds promise for uncovering novel genetic factors linked to traits like VO2max and injury susceptibility (25,26). Nonetheless, the field must address challenges such as data interpretation and the functional validation of identified genetic variants to ensure meaningful applications in sports contexts (24).The application of genomics raises important ethical considerations, particularly regarding data misuse, privacy concerns, and potential genetic discrimination (27). Athletes may face risks if sensitive information about their genetic predispositions is improperly disclosed or used to their detriment (28).Establishing clear ethical guidelines and robust policies is imperative for ensuring that genomics is applied responsibly and equitably in sports settings (29).Nutrigenomics, which examines the interaction between genetic variations and dietary needs, has demonstrated the potential for optimizing nutritional strategies based on individual genotypes (30)(31)(32). For example, the APOA2 genotype influences fatty acid metabolism, and specific dietary fat intakes can modify its effects, thereby affecting athletic performance (33,34). By identifying genotypes linked to nutrient processing efficiencies or sensitivities, practitioners can design diets that align with each athlete's metabolic profile. These approaches promise improvements in energy utilization, body composition, and overall performance, although robust validation through long-term, controlled studies remains necessary (35).Another example of the value of nutrigenomics is seen in individuals with genetic lactase nonpersistence, who exhibit altered gut microbiota and metabolite concentrations when consuming high amounts of milk (36,37). Tailoring dietary recommendations to avoid or limit lactose in such individuals not only mitigates discomfort but also enhances metabolic health and nutrient absorption (38). This precision approach exemplifies how genetic information can be used to refine nutritional guidance in ways that support both health and athletic performance, particularly through the modulation of gut microbiome function. Yet, further investigation is needed to establish standardized protocols for such applications (35).The identification of over 50,000 single nucleotide polymorphisms (SNPs) influencing cellular functions provides a vast dataset for crafting athlete-specific diets. These diets can address genetic predispositions impacting recovery, metabolism, and training adaptations. However, making this information actionable requires the development of user-friendly tools and platforms that can translate complex genetic data into practical recommendations for coaches and nutritionists (29,30).Nutrigenomics has also shown promise in optimizing macronutrient and micronutrient strategies for athletes. For instance, by identifying genetic susceptibilities to nutrient deficiencies, such as specific vitamin or mineral needs, tailored supplementation can be offered, potentially improving performance and recovery. Athletes with polymorphisms affecting vitamin D, iron, or folate metabolism may require personalized intake strategies to maintain optimal physiological status (38,39). This proactive approach can enhance immune function, reduce fatigue, and expedite recovery, offering competitive advantages. Nonetheless, the integration of these insights into sports nutrition programs is currently hindered by high testing costs and the lack of standardized implementation protocols across athletic organizations (40).Proteomics analyzes molecular-level changes in response to exercise, shedding light on the physiological processes involved in adaptation and recovery (41,42). The upregulation of proteins such as myoglobin and creatine kinase highlights their roles in muscle repair and immune response following intense activity (43). These findings provide a foundation for targeted nutritional and recovery interventions but require further research to elucidate how dietary factors can specifically modulate these protein responses (44).Salivary proteomic profiling has revealed a substantial increase in total salivary proteins after prolonged exertion, presenting a non-invasive method for assessing physical stress and recovery states (45,46). While promising, the applicability of salivary biomarkers in diverse athletic contexts needs further validation to establish their reliability and utility across different sporting disciplines (47).Exercise-induced modifications to protein structures, such as lysine acetylation, play crucial roles in regulating mitochondrial function and energy production, both essential for endurance performance (48). Understanding these molecular mechanisms can inform training programs aimed at enhancing mitochondrial efficiency; however, translating these insights into actionable recommendations for athletes is still in the early stages (49).Proteomic data has demonstrated how environmental factors, such as altitude, influence protein expression, enabling tailored strategies for athletes exposed to variable conditions (50,51) . For instance, specific dietary or training adaptations can be designed to mitigate performance declines at high altitudes. Integrating such insights into practice necessitates more comprehensive research on the interaction between environmental stressors and proteomic responses (52). Nutrition-centered proteomic studies have linked specific dietary interventions to enhanced recovery pathways in endurance athletes. These findings underscore the potential of proteomics to optimize performance; however, the development of cost-effective and scalable methods for analyzing proteomic data is critical for broader application in sports nutrition (7).Metabolomics has provided critical insights into metabolic responses during exercise, identifying key biomarkers like lactate and pyruvate that signal energy depletion (53,54). Nutritional strategies based on these biomarkers can enhance recovery by replenishing energy reserves more efficiently. However, standardization of analytical methods is necessary to ensure consistency across studies and practical applications (55). Post-exercise metabolomic profiling has identified changes in TCA cycle intermediates, ketone bodies, and lipid metabolites, which reflect recovery efficiency (56,57). These findings can inform targeted dietary interventions, but challenges like small sample sizes and variability in metabolic responses limit the generalizability of these results (58).The discovery of miR-532-5p as a biomarker for training adaptations demonstrates the potential of metabolomics to predict and monitor individual responses to exercise. While promising, the application of such biomarkers requires further validation to confirm their reliability and reproducibility in diverse athletic populations (59). Changes in metabolic pathways, such as shifts toward fatty acid metabolism and reduced glycolysis, are indicative of long-term adaptations to exercise that improve energy efficiency (60)(61)(62)(63). Precision nutrition strategies can leverage these insights to design training and dietary programs that maximize these benefits, though continued research is needed to optimize their integration (64). Lipidomics, a subset of metabolomics, has highlighted differential tissue-specific lipid metabolism responses to exercise, emphasizing the importance of tailoring endurance strategies based on individual metabolic profiles (56,65). However, the limited scalability of lipidomics due to cost and analytical requirements restricts its broader adoption (66).Multi-omics integration offers a holistic approach by combining datasets from genomics, proteomics, and metabolomics, among other fields, to derive a comprehensive understanding of athletic physiology (67)(68)(69)(70)(71). This approach supports the identification of precise, personalized interventions aimed at improving performance and health outcomes. The adoption of integrative platforms and emerging tools, such as OmicsAnalyst and artificial intelligence, facilitates the analysis of complex datasets, enabling improved precision in tailoring nutrition and training strategies (72,73). Yet, challenges such as ethical concerns, logistical hurdles, and data integration complexities persist, limiting the broader implementation of multi-omics approaches in real-world settings (74,75).Further highlighting the relevance of multi-omics, its role in individualized athlete monitoring is amplified by advancements in wearable technology and biosensors, which allow the real-time collection of metabolic and physiological data. Such technological innovations bridge the gap between laboratory-based analyses and everyday training environments, offering unprecedented opportunities for personalized interventions. However, the high costs and need for multidisciplinary cooperation to interpret these data remain substantial obstacles (76,77).The scalability of omics-based interventions remains a pressing issue, particularly given the limited accessibility of sophisticated technologies for amateur or under-resourced athletic groups.However, the potential for technological advancements, such as low-cost real-time monitoring systems, may gradually resolve these limitations, making precision nutrition more widely available. Continued efforts to improve the usability and affordability of multi-omics platforms will be vital in democratizing access to these tools, thereby broadening their impact across diverse athletic populations (78)(79)(80).Omics technologies offer immense potential for advancing sports nutrition, but addressing challenges related to cost, data integration, and ethical considerations is essential for their widespread application. Further research aimed at overcoming these limitations will be critical to maximizing the utility of omics-based precision nutrition in sports science.Metabolomic profiling during aerobic activity has identified significant changes in metabolite levels, including oxaloacetate and tyrosine, which are critical for energy production and mitochondrial function (44,(81)(82)(83). These metabolic shifts are particularly pronounced under hypoxic conditions, such as those encountered at high altitudes. Oxaloacetate is a crucial intermediate in the tricarboxylic acid (TCA) cycle, playing a vital role in energy metabolism, while tyrosine contributes to neurotransmitter synthesis and overall metabolic regulation during physical exertion (84,85). Tailored nutritional strategies that replenish these depleted intermediates can be employed to optimize recovery and support sustained performance during high-intensity activities. However, standardized methodologies for assessing these metabolite changes in diverse athletic populations remain lacking, limiting the broader applicability of such interventions. Future studies should prioritize larger sample sizes and account for individual variability in response to metabolic stress to refine these approaches (44).Hypoxic conditions further exacerbate systemic recovery challenges, as evidenced by metabolomic profiles that provide specific insights into altitude-specific nutritional requirements (Figure 2). These conditions necessitate tailored recovery protocols, with a particular focus on dietary interventions aimed at mitigating the physiological stresses imposed by reduced oxygen availability (86,87). For instance, high-altitude training could benefit from increased carbohydrate intake to counteract energy deficits and reduce reliance on protein catabolism for energy. Despite these promising applications, the complexities of individual metabolic responses to hypoxia underscore the need for personalized approaches and more precise analytical tools to support evidence-based recommendations (44). Advancements in wearable technology and mobile sensors now allow for real-time analysis of biomarkers such as sweat metabolites, offering immediate feedback on hydration levels and substrate utilization. These innovations enable athletes and their support teams to make on-the-spot adjustments to hydration and dietary intake, improving training and competition outcomes. The integration of biochemical data with digital platforms also bridges critical gaps in traditional nutritional monitoring methods (88)(89)(90)(91)(92). However, the implementation of wearable technology faces challenges, including variability in data accuracy and the complexity of interpreting results in real-world settings. Future research should explore ways to enhance the reliability of these devices while simultaneously simplifying their use for athletes and coaches (22).The amalgamation of wearable technologies with machine learning algorithms further enhances decision-making by identifying patterns in metabolic responses unique to each athlete. These datadriven insights facilitate the creation of highly specific nutrition plans that align with individual physiological needs (93,94). While the potential for machine learning to revolutionize personalized nutrition is substantial, the success of these tools depends on the availability of robust datasets and multidisciplinary collaboration to interpret complex interactions between genetics, environment, and training. Additionally, ethical considerations regarding data security and athlete privacy must be addressed before these technologies can be widely adopted in high-performance settings (22).Post-exercise nutritional interventions involving macronutrient combinations, particularly proteins and carbohydrates, have demonstrated the ability to enhance recovery by simultaneously reducing muscle protein breakdown and promoting glycogen resynthesis (95)(96)(97). Low-carbohydrate, protein-rich beverages have been shown to modulate catabolic and anabolic markers effectively, with reductions in 3-methylhistidine levels indicating decreased muscle protein degradation and increases in pseudouridine signaling improved cellular recovery (98,99). While promising, these findings reveal the complexity of optimizing recovery strategies for varying athletic demands and fitness levels. Athletes with lower fitness levels, for example, may benefit disproportionately from such tailored macronutrient interventions, as their recovery states are often more metabolically compromised. Nonetheless, the practical implementation of these dietary strategies requires further investigation into individual variability and long-term efficacy (100).Proteomic analyses have revealed that post-exercise recovery is associated with the upregulation of specific proteins, including myoglobin and creatine kinase, which play central roles in muscle repair and adaptation. Myoglobin facilitates oxygen transport within muscle cells, while creatine kinase is pivotal in energy homeostasis and cellular repair mechanisms (101,102). Monitoring these proteins provides valuable insights into how athletes respond to physical stress, offering opportunities to design more targeted recovery protocols. Expanding proteomic applications to include the analysis of immune response proteins could further elucidate how inflammatory processes are managed postexercise. While these advances hold significant promise, their widespread application is hindered by the high costs and technical expertise required to implement proteomic testing on a larger scale (44,103).High-intensity exercise conducted in hot environmental conditions induces significant metabolic changes, such as elevated lactate and glucose levels, reflecting increased reliance on anaerobic pathways for energy production (104)(105)(106). These findings stress the importance of implementing hydration strategies that address both fluid loss and the heightened metabolic demands associated with heat stress. Specific carbohydrate supplementation regimens that align with environmental factors can mitigate fatigue and support energy efficiency during prolonged activity in such conditions. Nevertheless, further research is needed to establish comprehensive nutritional guidelines that address the interaction between environmental stressors and individual metabolic responses, ensuring these strategies are adaptable across various athletic populations (107).Research indicates that combining glucose with other carbohydrates, such as fructose, enhances carbohydrate oxidation rates beyond 1 g/min, significantly improving endurance performance during extended physical activity (108). This metabolic enhancement is particularly relevant for athletes engaged in long-duration or high-intensity events. Genetic and metabolic variability among individuals further emphasizes the need for personalized carbohydrate supplementation plans. Tools such as nutrigenomics can identify single nucleotide polymorphisms (SNPs) that influence metabolic pathways, providing a basis for designing individualized macronutrient strategies. However, the complexity and cost of implementing these genomic insights at scale remain substantial barriers to their widespread adoption (109).Multi-omics approaches, which integrate genomics, proteomics, and metabolomics, allow for comprehensive tracking of an athlete's physiological responses, thereby enhancing the precision of dietary recommendations (110). This holistic perspective supports the design of interventions that not only address immediate performance needs but also facilitate long-term adaptations to training and competition demands. Tools like OmicsAnalyst have significantly advanced the field by enabling the integration of multi-modal datasets, yet their utility is limited by logistical challenges and the expertise required for data interpretation. Future efforts should focus on making these platforms more accessible and user-friendly while addressing ethical and privacy concerns associated with multi-omics data usage (40).The application of precision nutrition extends to addressing specific challenges faced by athletes, such as menstrual dysfunction in female athletes. Tailored macronutrient modulation and supplementation strategies have been shown to optimize hormonal health and overall performance in this context (111)(112)(113)(114)(115). These interventions are particularly valuable for reducing the risk of stressinduced illnesses and supporting recovery from intensive training loads. However, gender-sensitive research in sports nutrition remains underrepresented, highlighting the need for more diverse and inclusive studies to refine these strategies further (116).Long-term exercise has been shown to induce metabolic adaptations, such as improved betaoxidation of fatty acids and reduced glycolysis reliance, enhancing energy efficiency. These shifts not only improve immediate athletic performance but also contribute to systemic benefits, such as reduced inflammation and better cardiovascular health. Insights into these adaptations can guide more effective training and nutritional strategies tailored to individual metabolic profiles. Moreover, research indicates that the benefits of exercise extend beyond metabolic efficiency, influencing neurological health and reducing the risk of neurodegenerative diseases. For instance, sustained physical activity has been shown to enhance brain-derived neurotrophic factor (BDNF) expression, which plays a protective role in conditions such as Alzheimer's disease. These findings, derived from multi-omics studies, demonstrate the far-reaching physiological advantages of long-term exercise and further emphasize the importance of holistic approaches to athlete training plans (117,118).Urinary metabolome changes occurring after strenuous exercise provide valuable indicators of recovery states and potential pathways for intervention. For example, reduced concentrations of specific metabolites highlight the physiological stress imposed by intensive activity, offering markers for targeted recovery strategies (56). Leveraging these biomarkers can enhance the precision of postcompetition nutritional protocols, allowing for faster and more effective recovery. However, the transient nature of these metabolic shifts raises questions about their reliability as long-term indicators, necessitating further exploration of their clinical utility (119).Genetic markers associated with endurance traits and injury susceptibility offer critical insights for developing proactive training and nutrition plans. These markers facilitate the customization of workloads and recovery schedules to align with an athlete's genetic predispositions, thereby reducing the risk of overtraining and related injuries (120,121). Such targeted strategies not only enhance training outcomes but also safeguard long-term physical health. Despite this potential, challenges in translating genetic findings into actionable recommendations persist, underscoring the need for ongoing research to refine their practical applications (7).In conclusion, applying omics technologies to athletic performance and recovery offers significant potential for advancing personalized nutrition strategies (Figure 3). By addressing existing challenges, such as cost, scalability, and data integration, future research can unlock new opportunities to enhance both immediate and long-term athletic outcomes. The integration of omics technologies into sports nutrition represents a transformative advancement, offering a granular understanding of individual responses to training, recovery, and dietary interventions. Advances across genomics, transcriptomics, proteomics, metabolomics, and microbiomics have enabled the identification of key molecular markers linked to nutrient metabolism, inflammation, muscle adaptation, and fatigue. These technologies have deepened our understanding of how individual genetic variations influence macronutrient utilization, supplement efficacy, and injury susceptibility. For instance, genomics can inform personalized carbohydrate intake strategies, while metabolomics provides real-time snapshots of energy expenditure and recovery status (7). Additionally, gut microbiome profiling offers novel insights into immune modulation and nutrient absorption (122).When combined, these omics approaches form a systems biology perspective that allows for highly individualized nutritional recommendations tailored to the physiological and metabolic demands of athletes. However, despite these scientific advances and pilot applications in elite sports settings, practical translation into routine use remains limited due to issues of standardization, cost, and the need for multidisciplinary expertise. Thus, while the foundational science has made substantial progress in mapping molecular pathways and identifying performance-related biomarkers, we argue that the next phase of development must shift toward pragmatic, scalable, and ethically sound applications that can be implemented across a broader spectrum of athletic populations.Based on our assessment, we believe that the most urgent future direction is the standardization and validation of multi-omics protocols tailored for athletic populations. This includes harmonizing data collection methods across genomics, proteomics, and metabolomics to allow meaningful comparisons and real-time interpretations. Despite the growing popularity of multi-omics approaches, a lack of standardized bioinformatics pipelines and inconsistencies in sampling procedures limit their reproducibility and translational impact (123). We propose that developing open-access databases and AI-enhanced interpretation frameworks-customized for the athletic context-should become a priority for the research community.Real-world implementation will depend heavily on cost-effective solutions and interdisciplinary collaboration. Although the current literature demonstrates promising correlations between molecular profiles and performance metrics, translating these insights into actionable strategies remains restricted to elite or well-funded institutions. Wearable biosensors and mobile metabolitetracking technologies offer an encouraging route to democratize access, but require rigorous validation.We recommend future research prioritize affordability and simplicity of user interfaces, ensuring that omics-driven interventions become accessible to a broader range of athletes, including those in amateur and resource-limited contexts.We also emphasize that a critical bottleneck lies in the ethical and legal landscape surrounding omics applications. While genomics and other omics data hold immense predictive value, there is an acute risk of misuse, especially in competitive sports environments where pressure to outperform is high. We propose that future studies be accompanied by concurrent development of governance frameworks that address data ownership, informed consent, genetic discrimination, and psychological impacts of predictive findings. Without these, the integration of omics technologies could exacerbate inequities or introduce new forms of athlete exploitation. Furthermore, we contend that the field needs a more nuanced understanding of geneenvironment-nutrition interactions. We believe that focusing exclusively on single molecular domains may obscure synergistic effects that only become apparent through longitudinal, integrative designs.For example, identifying how specific genotypes respond to macronutrient timing under varied environmental stressors-such as altitude or heat-could redefine how training programs are individualized. Such findings will not emerge from siloed research but from multi-center trials incorporating behavioral, physiological, and omics data.Lastly, we assert that the educational and professional development of practitioners must evolve alongside technological advancements. Nutritionists, trainers, and coaches require upskilling to interpret and implement omics findings responsibly. We propose that curricula in sports science and nutrition incorporate modules on omics literacy, data ethics, and applied systems biology. Only by equipping practitioners with adequate tools can we ensure that precision nutrition transitions from concept to routine practice.In conclusion, omics-based precision nutrition holds enormous promise but is still in a formative stage of development. We propose that future research prioritize integration, accessibility, ethical rigor, and practitioner training to ensure the field progresses in a sustainable and equitable manner. This vision necessitates not only scientific innovation but also coordinated efforts across disciplines, institutions, and stakeholder communities. Only through such a comprehensive approach can we unlock the full potential of precision nutrition to enhance both performance and well-being in diverse athletic populations.The overarching aim of this work was to investigate how omics technologies-including genomics, nutrigenomics, proteomics, and metabolomics-can enhance precision nutrition to optimize athletic performance, recovery, and injury prevention. Through a synthesis of current research, the study demonstrates how the integration of these molecular approaches facilitates personalized dietary and training interventions tailored to each athlete's unique biological profile. Omics technologies are shown to transform traditional sports nutrition by shifting from generalized recommendations to highly individualized strategies, thereby improving both short-term performance and long-term health outcomes. Genomic analyses have revealed key markers such as PPARGC1A and PPARD linked to endurance, though challenges such as limited reproducibility in elite populations persist. Nutrigenomics has underscored the influence of genetic predispositions-e.g., APOA2 variants and lactase nonpersistence-on dietary responses, while proteomics and metabolomics have respectively illuminated the roles of exercise-responsive proteins (e.g., creatine kinase, myoglobin) and metabolic biomarkers (e.g., lactate, pyruvate) in recovery and energy balance. Integrating these domains through a multiomics framework offers a holistic understanding of athletic physiology by capturing the dynamic interplay between genes, proteins, metabolites, and environmental factors. Moreover, this research situates omics within broader efforts in precision medicine, with initiatives like the Athlome Consortium highlighting the value of collaborative biomarker validation. Nonetheless, significant barriers remain, including high implementation costs, complex technological requirements, the need for multidisciplinary data interpretation, and ethical concerns around genetic testing and data privacy. The review also notes that limitations in current literature-such as methodological variability and small sample sizes-hinder generalizability, while the inaccessibility of omics tools to non-elite athletes and the absence of standardized protocols for multi-omics integration constrain practical adoption.Addressing these challenges will be critical to democratizing omics-driven sports nutrition and ensuring its equitable, responsible, and impactful implementation.Future research must prioritize the refinement of omics technologies to overcome these barriers and expand their applicability (Figure 4). Key areas for exploration include standardizing methodologies for multi-omics integration, developing real-time monitoring systems enabled by wearable biosensors, and enhancing the affordability and usability of omics platforms (Figure 4). Interdisciplinary collaboration among sports scientists, nutritionists, molecular biologists, and data specialists will be critical in transforming omics research into practical solutions. Additionally, greater emphasis on inclusivity and diversity in research is essential to ensure that omics-based strategies are applicable across all athletic populations, including underrepresented groups such as female athletes and those from diverse genetic backgrounds. Through this work, the immense potential of omics technologies to revolutionize sports nutrition has been highlighted. These approaches not only address immediate performance and recovery needs but also contribute to a more comprehensive understanding of human biology, offering systemic benefits that extend beyond the athletic domain. Writing this review has reinforced the importance of integrating cutting-edge molecular research with practical sports applications, inspiring a commitment to pursue advancements that enhance human potential and well-being. By addressing current challenges and fostering interdisciplinary collaboration, omics-based precision nutrition stands poised to set new standards in sports science and personalized health care. This work contributes to that vision by bridging theoretical knowledge with practical implications, establishing a foundation for future research aimed at unlocking the full potential of these transformative technologies.