ORIGINAL RESEARCH article
Front. Nutr.
Sec. Nutrition and Metabolism
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1612149
This article is part of the Research TopicBioactive Metabolites in Traditional Medicine: Dual Pathways to Metabolic HealthView all 5 articles
Unveiling the Therapeutic Mechanisms of Saorilao-4 Decoction in Pulmonary Fibrosis through Metabolomics and Transcriptomics
Provisionally accepted
Jiali Liu1*
Xiaowen Song1
Xinni Song1
Xinyue Fu1Shufang Niu1
Chang Hong1
Songli Shi1Meiqing Yang1
Ruiqi Zhao1
Peng Wang2Jun Qi3,4
WanFu Bai1*- 1Baotou Medical College, Baotou, China
- 2Second Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, China
- 3Department of Radiology, First Affiliated Hospital of Baotou Medical College, Baotou, China
- 4First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, China
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Pulmonary fibrosis (PF) is a challenging and intricate lung ailment to treat. Saorilao-4 decoction (SRL) is a traditional Mongolian medicine remedy frequently utilized in the management of lung disorders. This study employed transcriptomics and metabolomics to explore the molecular mechanisms of SRL in the bleomycin-induced PF rat model. Additionally, histopathological analysis and the assessment of serum biochemical indices were utilized to investigate the potential mitigating effects of SRL on PF. Transcriptomics and metabolomics analyses indicate that SRL primarily modulates the AMPK and PPAR signaling pathways by regulating genes such as Scd, Fads2, Cpt1a, Lipe, Pfkfb3 and Hmgcs2. Thereby influencing biomarkers such as S-Adenosylmethioninamine, 16-Hydroxyhexadecanoic acid and Proline, mitigating metabolic disorders in pathways such as arginine and proline metabolism, vitamin B6 metabolism, fatty acid degradation and arachidonic acid metabolism. The present study reveals the regulation of unsaturated fatty acid-related metabolic pathways in vivo and elucidates the mechanism of action of SRL in ameliorating PF.
Keywords: Pulmonary Fibrosis, Saorilao-4 decoction, Mongolian medicine, Transcriptomics, Metabolomics
Received: 15 Apr 2025; Accepted: 09 Jul 2025.
Copyright: © 2025 Liu, Song, Song, Fu, Niu, Hong, Shi, Yang, Zhao, Wang, Qi and Bai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiali Liu, Baotou Medical College, Baotou, China
WanFu Bai, Baotou Medical College, Baotou, China
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