ORIGINAL RESEARCH article
Front. Nutr.
Sec. Clinical Nutrition
Volume 12 - 2025 | doi: 10.3389/fnut.2025.1614263
This article is part of the Research TopicLipids and Wasting Disorders in Disease and AgingView all 6 articles
Association of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and sarcopenia in elderly adults
Provisionally accepted
- 1Wenzhou People’s Hospital, Wenzhou, Zhejiang Province, China
- 2Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
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Background: This study aimed to explore the link between NHHR and sarcopenia in elderly adults using data from the National Health and Nutrition Examination Survey (NHANES).Methods: The dataset from NHANES 1999-2004. Different statistical analyses, including logistic regression, restricted cubic spline, two-piecewise linear regression, subgroup analyses, and interaction tests models, were used to examine the relationship between NHHR and the risk of sarcopenia.Results: Total 3,190 elderly participants were included and 676 (21.2%) of them had sarcopenia. In crude model, the odds ratio (OR) of NHHR on sarcopenia was 0.71 [95% confidence interval (CI), 0.66–0.77]. After adjusting for all factors, the ORs for NHHR tertiles 2 and 3 were 0.76 (95% CI: 0.58–0.99) and 0.70 (95% CI: 0.53–0.94), respectively, with a significant trend (p =0.014). An L-shaped relationship between NHHR and sarcopenia was found (P for nonlinearity = 0.046), with 3.01 being the inflection point. Subgroup analysis results indicated a stable and persistent association between NHHR and sarcopenia across multiple subgroups, with the exception of diabetes.Conclusions: We found that NHHR was negatively associated with risk of sarcopenia in the elderly adults.
Keywords: NHHR, Lipids, Sarcopenia, Elderly, NHANES
Received: 18 Apr 2025; Accepted: 12 Jun 2025.
Copyright: © 2025 Lin, Shi, Wu and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiyi Chen, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
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